Toward Supertough and Heat-Resistant Stereocomplex-Type Polylactide/Elastomer Blends with Impressive Melt Stability via <i>in Situ</i> Formation of Graft Copolymer during One-Pot Reactive Melt Blending

Deng, Shihao; Bai, Hongwei; Liu, Zhenwei; Zhang, Qin; Fu, Qiang

doi:10.1021/acs.macromol.8b02626

Cited by 103 publications

(53 citation statements)

References 66 publications

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“…Ultimately, this change in a biodegradable polymer can result in an increase in thermal stability, mechanical strength, resistance against solvent penetration, and external forces. Stereocomplex crystals in PLA have commonly been formed by solution blending, melt blending, emulsion blending, precipitation into non-solvent, and supercritical fluid (SCF) techniques [ 4 , 5 , 6 , 7 , 8 , 9 ]. Each method has different advantages and disadvantages regarding the yield and stereocomplexation efficiency, processability, solubility, time, and cost.…”

Section: Introductionmentioning

confidence: 99%

Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Park

et al. 2021

Molecules

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Polylactide (PLA) is among the most common biodegradable polymers, with applications in various fields, such as renewable and biomedical industries. PLA features poly(D-lactic acid) (PDLA) and poly(L-lactic acid) (PLLA) enantiomers, which form stereocomplex crystals through racemic blending. PLA emerged as a promising material owing to its sustainable, eco-friendly, and fully biodegradable properties. Nevertheless, PLA still has a low applicability for drug delivery as a carrier and scaffold. Stereocomplex PLA (sc-PLA) exhibits substantially improved mechanical and physical strength compared to the homopolymer, overcoming these limitations. Recently, numerous studies have reported the use of sc-PLA as a drug carrier through encapsulation of various drugs, proteins, and secondary molecules by various processes including micelle formation, self-assembly, emulsion, and inkjet printing. However, concerns such as low loading capacity, weak stability of hydrophilic contents, and non-sustainable release behavior remain. This review focuses on various strategies to overcome the current challenges of sc-PLA in drug delivery systems and biomedical applications in three critical fields, namely anti-cancer therapy, tissue engineering, and anti-microbial activity. Furthermore, the excellent potential of sc-PLA as a next-generation polymeric material is discussed.

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Section: Introductionmentioning

confidence: 99%

Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Park

et al. 2021

Molecules

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“…[ 13–16 ] Using rubber particles to toughen PLLA has proved to be a simple and economical method. [ 17–20 ] But the serious problem of poor interfacial interaction between rubber and PLLA is ubiquitous in this method, which would lead to a rather low toughening efficiency. [ 21–23 ] Compared with the complex interfacial modification methods of reactive compatibilizing or synthesizing copolymer compatibilizers, in recent years, toughening PLLA with core‐shell rubber nanoparticles has attracted much more attention due to their good interfacial modification effect, low cost, and easy industrialized production.…”

Section: Introductionmentioning

confidence: 99%

Stereocomplex Crystallization Induced Significant Improvement in Transparency and Stiffness–Toughness Performance of Core‐Shell Rubber Nanoparticles Toughened Poly(l‐lactide) Blends

Liu

Bai

Ду

et al. 2021

Macro Materials & Eng

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Toughening modification of poly(l‐lactide) (PLLA) with rubber particles is often realized at the cost of transparency, mechanical strength, and modulus because high rubber loadings are generally required for toughening. In this work, a promising strategy to simultaneously improve the transparency and stiffness–toughness performance of poly(butyl acrylate)‐poly(methyl methacrylate) (BAMMA) core‐shell rubber nanoparticles toughened PLLA blends by utilizing the stereocomplex (SC) crystallization between PLLA and poly(d‐lactide) (PDLA) is devised. The results reveal that the construction of SC crystallites in PLLA matrix via melt‐mixing PLLA/BAMMA blends with PDLA can prevent BAMMA nanoparticles from aggregation and promote them to form network‐like structure at lower contents. As a result, not only higher toughening efficiency with less rubber contents but also superior transparency is achieved in the PLLA/PDLA/BAMMA blends as compared with the PLLA/BAMMA ones where large aggregated BAMMA clusters are formed. Moreover, the outstanding reinforcement of SC crystallites network for PLLA can impart an enhanced tensile strength and modulus to PLLA/PDLA/BAMMA blends, thus improving the stiffness–toughness performance of PLLA/PDLA/BAMMA blends to a higher degree. This work demonstrates that SC crystallization is a promising solution to solve the contradiction between transparency and mechanical properties and then obtain superior comprehensive performances in rubber toughened PLLA blends.

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“…Various strategies have been developed to prepare ductile PLLA. As a typical example, it has been blended with flexible polymers [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 ]. In these multicomponent blend systems, phase separation always occurs due to the poor miscibility of them [ 14 , 15 ].…”

Section: Introductionmentioning

confidence: 99%

Improvement of PLLA Ductility by Blending with PVDF: Localization of Compatibilizers at Interface and Its Glycidyl Methacrylate Content Dependency

Zhang

et al. 2020

Polymers

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In this work, the localization of reactive compatibilizer (RC, containing poly(methyl methacrylate) (PMMA) backbone with randomly distributed glycidyl methacrylate (GMA) on it) at the polyvinylidene fluoride/poly(l-lactic acid) (PVDF/PLLA) interface has been manipulated by means of GMA contents. At the very beginning of mixing, RC tends to stay in the PVDF phase due to the miscibility between PVDF and PMMA. Upon further shearing, more and more PLLA chains have been grafted on PMMA backbone, producing PLLA–g–PMMA copolymer. The balanced stress on two sides accounts for the localization of compatibilizers at the PVDF/PLLA interface. Finally, the stress of the PLLA side has been enhanced remarkably due to the higher graft density of PLLA, resulting in the enrichment of the copolymer in the PLLA matrix. The migration of RC from the PVDF phase to the immiscible interface and PLLA matrix can be accelerated by employing RC with higher GMA content. Furthermore, the compatibilizer localization produces a significant influence on the morphology and ductility of the PVDF/PLLA blend. Only when the compatibilizers precisely localize at the interface, the blend exhibits the smallest domain and highest elongation at break. Our results are of great significance for not only the fabrication of PLLA with high ductility, but also the precise localization of compatibilizers at the interface of the immiscible blend.

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Toward Supertough and Heat-Resistant Stereocomplex-Type Polylactide/Elastomer Blends with Impressive Melt Stability via in Situ Formation of Graft Copolymer during One-Pot Reactive Melt Blending

Cited by 103 publications

References 66 publications

Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Stereocomplex Polylactide for Drug Delivery and Biomedical Applications: A Review

Stereocomplex Crystallization Induced Significant Improvement in Transparency and Stiffness–Toughness Performance of Core‐Shell Rubber Nanoparticles Toughened Poly(l‐lactide) Blends

Improvement of PLLA Ductility by Blending with PVDF: Localization of Compatibilizers at Interface and Its Glycidyl Methacrylate Content Dependency

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