2018
DOI: 10.1016/j.conb.2018.01.012
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Toward true closed-loop neuromodulation: artifact-free recording during stimulation

Abstract: Closed-loop and responsive neuromodulation systems improve open-loop neurostimulation by responding directly to measured neural activity and providing adaptive, on-demand therapy. To be effective, these systems must be able to simultaneously record and stimulate neural activity, a task made difficult by persistent stimulation artifacts that distort and obscure underlying biomarkers. To enable simultaneous stimulation and recording, several techniques have been proposed. These techniques involve artifact-preven… Show more

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Cited by 101 publications
(84 citation statements)
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“…This approach offers a third alternative, retaining the low tissue damage of small microwires, while enabling rapid application of cutting-edge silicon array technology to neuroscience. Additional advances in CMOS technology, such as low-artifact stimulation 64 , higher channel counts 21 and electrochemical monitoring 65,66 , can be rapidly deployed using this system. Our design is favorable for recording or stimulation experiments that require large area coverage and high density, such as in the visual cortex.…”
Section: Resultsmentioning
confidence: 99%
“…This approach offers a third alternative, retaining the low tissue damage of small microwires, while enabling rapid application of cutting-edge silicon array technology to neuroscience. Additional advances in CMOS technology, such as low-artifact stimulation 64 , higher channel counts 21 and electrochemical monitoring 65,66 , can be rapidly deployed using this system. Our design is favorable for recording or stimulation experiments that require large area coverage and high density, such as in the visual cortex.…”
Section: Resultsmentioning
confidence: 99%
“…This involves (1) using recorded neural responses to control the hand, (2) stimulating somatosensory neurons to provide tactile and proprioceptive feedback, and (3) ensuring that stimulation artifacts do not corrupt the recorded signals being used to control the hand. Several artifact reduction methods have been proposed for (3) -we refer the reader to [32,33,34]. We focus here on combining (1) decoding with (2) encoding.…”
Section: Closed-loop Prosthetic Controlmentioning
confidence: 99%
“…These artifacts can mask the LFP signal and the underlying biomarkers. Most of the research in closed loop DBS is focused on removing and suppressing stimulation artifacts, which is prominent in all closed-loop DBS devices and bi-directional BMIs [6], [7], [8]. This issue is easily observed on the bench.…”
Section: Introductionmentioning
confidence: 99%