Towards a modern approach to traditional use: in vitro and in vivo evaluation of Alchemilla vulgaris L. gel wound healing potential

Tasić‐Kostov, Marija; Arsić, Ivana; Pavlović, Dragana; Stojanović, Sanja; Najman, Stevo; Naumović, Sonja; Tadić, Vanja

doi:10.1016/j.jep.2019.03.016

Cited by 30 publications

(30 citation statements)

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“…IC 50 values of effect Alchemilla vulgaris extracts in cytotoxicity Unported Licence.ethnobotanical notes for the Balkan region15 and as a novel report presented in our current studyfor treating the neurodegenerative disorders, including Alzheimer and Parkinson's disease.…”

mentioning

confidence: 64%

“…vulgaris). 15 Among ethnobotanical reports on Alchemilla vulgaris for Southeast Europe and the territory of Balkan peninsula, it is to mention a comprehenisve work of Tucakov (1997), and his reports on adstringent and antidiarrheal, as well as effects against pruritus vulvae, bleeding from uterus and menstrual pains. The most used folk names according to Simonovic (1959) are: "virak", "vrkuta", "rosanica", "biserak", "virkovina", "virić" and "gospinplašt" (it is interesting that the latter literally means Lady's mantle).…”

Section: Introductionmentioning

confidence: 99%

“…There are also reports which have shown that plants from Alchemilla genus were traditionally used for skin and neurodegenerative disorders and against diabetes and gastrointestinal problems of this plant, [14][15][16][17] its ability to inhibit anti-cholinesterase, 41 anti-tyrosinase and anti-amylase activity of A. vulgaris extracts will be investigated in this study.…”

Section: Introductionmentioning

confidence: 99%

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Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties

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confidence: 64%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties

et al. 2019

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“…For thousands of years, many natural resources have been reported to be used for skin injury. Over the last 10 years, many studies have reported evidence that natural products can improve skin wounds [7]. As part of such research, this study was conducted to demonstrate the pharmacological function of elm tree for skin wounds.…”

Section: Introductionmentioning

confidence: 99%

Ulmus parvifolia Accelerates Skin Wound Healing by Regulating the Expression of MMPs and TGF-β

Kang

Yumnam

Park

et al. 2019

JCM

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Ulmus parvifolia is one of the medicinal plants used traditionally for treatment of wounds. We intended to investigate the wound healing effect of the powder of Ulmus parvifolia (UP) root bark in a mouse wound healing model. We also determined the mechanisms of effects of U. parvifolia in skin and skin wound healing effects using a keratinocyte model. Animal experiments showed that the wound lesions in the mice decreased with 200 mesh U. parvifolia root bark powder and were significantly reduced with treatment by UP, compared with those treated with Ulmus macrocarpa (UM). Results from in vitro experiments also revealed that UP extract promoted the migration of human skin keratinocytes. UP powder treatment upregulated the expression of the matrix metalloproteinase-2 and -9 protein and significantly increased transforming growth factor (TGF)-β levels. We confirmed that topical administration of the bark powder exerted a significant effect on skin wound healing by upregulating the expression of MMP and transforming growth factor-β. Our study suggests that U. parvifolia may be a potential candidate for skin wound healing including epidermal skin rejuvenation.

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“…Actually, over the last 10 years, many papers have been reported evidences that natural products can improve skin wounds. [6]. As part of such research, this study was conducted to demonstrate the pharmacological function of elm tree for skin wounds.…”

Section: Introductionmentioning

confidence: 99%

Ulmus Parvifolia Accelerate Skin Wound Healing by Regulating the Expression of MMPs and TGF-β

Kang¹,

Yumnam²,

Park³

et al. 2019

Preprint

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Ulmus species have been widely used in Korean folk medicine because of their anti-inflammatory and antimicrobial properties. We intended to investigate the wound healing effect of the powder of Ulmus parvifolia (UP) root bark in a mouse wound healing model. We also determined the mechanisms of effects of Ulmus parvifolia (UP) in skin and skin wound healing effect using keratinocyte model. in vivo experiments showed that the wound lesions in the mice decreased by U. parvifolia with 200 mesh size of root bark powder and significantly reduced by treatment with UP, compared with those treated with U. macrocarpa (UM). Results from in vitro experiments also revealed that UP extract promoted the migration of human skin keratinocytes. UP powder treatment upregulated the expression of the matrix metalloproteinase-2 and -9 protein and significantly increased transforming growth factor (TGF)-β levels. We confirmed that topical administration of the bark powder of exerted a significant effect on skin wound healing by upregulating the expression of MMP and transforming growth factor-β. TGF-β In, Our study suggests that U. parvifolia may be a potential candidate for skin wound healing including epidermal skin rejuvernation.

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Towards a modern approach to traditional use: in vitro and in vivo evaluation of Alchemilla vulgaris L. gel wound healing potential

Cited by 30 publications

References 61 publications

Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties

Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties

Ulmus parvifolia Accelerates Skin Wound Healing by Regulating the Expression of MMPs and TGF-β

Ulmus Parvifolia Accelerate Skin Wound Healing by Regulating the Expression of MMPs and TGF-β

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Towards a modern approach to traditional use: in vitro and in vivo evaluation of Alchemilla vulgaris L. gel wound healing potential

Cited by 30 publications

References 61 publications

Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties

Alchemilla vulgaris agg. (Lady's mantle) from central Balkan: antioxidant, anticancer and enzyme inhibition properties

Ulmus parvifolia Accelerates Skin Wound Healing by Regulating the Expression of MMPs and TGF-β

Ulmus Parvifolia Accelerate Skin Wound Healing by Regulating the Expression of MMPs and TGF-&beta;

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Ulmus Parvifolia Accelerate Skin Wound Healing by Regulating the Expression of MMPs and TGF-β