Towards bilirubin imprinted poly(methacrylic acid-co-ethylene glycol dimethylacrylate) for the specific binding of α-bilirubin

Syu, Mei-Jywan; Deng, Jing Hong; Nian, You Ming

doi:10.1016/s0003-2670(03)00879-1

Cited by 30 publications

(10 citation statements)

References 28 publications

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“…For the former case, bilirubin can be changed into a more soluble form and can easily be excreted and, for the latter case, adsorbents can be used for extracoroporal removal of bilirubin from blood by haemoperfusion. Activated charcoal,7 agar,8 polylysine‐immobilized chitosan beads,9 β‐cyclodextrin supported by partially aminated polyacrylamide gel,10 Cibacron Blue‐F3GA‐immobilized adsorbents,11, 12 bilirubin‐imprinted poly[(methacrylic acid)‐ co ‐(ethylene glycol dimethacrylate)]13 and albumin‐immobilized polymeric sorbents14–15 have been used for the adsorption of bilirubin. The efficiency of affinity adsorbents depends on several factors, such as biocompatibility, type and number of adsorptive site, size of particle and swelling degree, which affect the performance of adsorbents in haemoperfusion 16…”

Section: Introductionmentioning

confidence: 99%

Polyethylenimine‐grafted and HSA‐immobilized poly(GMA–MMA) affinity adsorbents for bilirubin removal

Arıca

Yalçın

Bayramoğlu

2004

Polymer International

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The epoxy‐group‐containing microspheres from cross‐linked glycidyl methacrylate and methyl methacrylate, poly(GMA–MMA), were prepared by suspension polymerisation. The epoxy groups of the poly(GMA–MMA) microspheres were used for grafting with an anionic polymer polyethylenimine (PEI) to prepare non‐specific affinity adsorbents (poly(GMA–MMA)–PEI) for bilirubin removal. The specificity of the poly(GMA–MMA)–PEI adsorbent to bilirubin was further increased by immobilization of human serum albumin (HSA) via adsorption onto PEI‐grafted poly(GMA–MMA) adsorbent. Various amounts of HSA were immobilized on the poly(GMA–MMA)–PEI adsorbent by changing the medium pH and initial HSA concentration. The maximum HSA content was obtained at 68.3 mg g−1 microspheres. The effects of pH, ionic strength, temperature and initial bilirubin concentration on the adsorption capacity of both adsorbents were investigated in a batch system. Separation of bilirubin from human serum was also investigated in a continuous‐flow system. The bilirubin adsorption on the poly(GMA–MMA)–PEI and poly(GMA–MMA)–PEI–HSA was not well described by the Langmuir model, but obeyed the Freundlich isotherm model. The poly(GMA–MMA)–PEI affinity microspheres are stable when subjected to sanitization with sodium hydroxide after repeated adsorption–desorption cycles. Copyright © 2004 Society of Chemical Industry

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Section: Introductionmentioning

confidence: 99%

Polyethylenimine‐grafted and HSA‐immobilized poly(GMA–MMA) affinity adsorbents for bilirubin removal

Arıca

Yalçın

Bayramoğlu

2004

Polymer International

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“…Contudo, sensores ópticos baseados em mudanças de cor também poderão ser construídos, visto que alguns trabalhos relatados na literatura, já reportaram a preparação de MIP que podem ser usados com esta finalidade [91][92][93] .…”

Section: Tabelaunclassified

Polímeros biomiméticos em química analítica. Parte 2: aplicações de MIP ("Molecularly Imprinted Polymers") no desenvolvimento de sensores químicos

Tarley¹,

Sotomayor²,

Kubota³

2005

Quím. Nova

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Recebido em 10/12/04; aceito em 3/3/05; publicado na web em 10/8/05 BIOMIMETIC POLYMERS IN ANALYTICAL CHEMISTRY. PART 2: APPLICATIONS OF MIP (MOLECULARLY IMPRINTED POLYMERS) IN THE DEVELOPMENT OF CHEMICAL SENSORS. The aim of this paper is the description of the strategies and advances in the use of MIP in the development of chemical sensors. MIP has been considered an emerging technology, which allows the synthesis of materials that can mimic some highly specific natural receptors such as antibodies and enzymes. In recent years a great number of publications have demonstrated a growth in their use as sensing phases in the construction of sensors . Thus, the MIP technology became very attractive as a promising analytical tool for the development of sensors.Keywords: molecularly imprinted polymers; biomimetic sensors. INTRODUÇÃOA biomimetização de interações bioquímicas é um dos maiores desafios em várias áreas da ciência. A partir deste ponto de vista, polímeros sintéticos com impressão molecular, mais conhecidos como MIP ("Molecularly Imprinted Polymers") têm atraído considerável atenção na última década, pois aparecem como uma ferramenta promissora para o desenvolvimento de sistemas com reconhecimento biomimético semelhante aos sistemas específicos enzima-substrato e/ou antígeno-anticorpo 1 . As vantagens dos MIP em relação aos materiais biológicos (enzimas e anticorpos) incluem fácil preparo, baixo custo; possibilidade de síntese em situações onde nenhuma biomolécula (receptor ou enzima) se encontra disponível ou quando elas possuem um alto preço e, resistência a ambientes adversos, nos quais biomoléculas naturais não resistiriam, como na presença de ácidos, bases, íons metálicos, solventes orgânicos, altas temperaturas e alta pressão 2,3 . Ainda, os MIP podem ser armazenados a seco em temperatura ambiente por longos períodos de tempo, sem perda do desempenho inicial.Devido aos sítios de ligação dos MIP, que apresentam afinidades e seletividades aproximadas aos dos sistemas anticorpoantígeno, estes materiais são designados como polímeros biomiméticos. Neste sentido, não é surpreendente que exista atualmente uma forte tendência do seu uso como elementos de reconhecimento em sensores biomiméticos, em face da grande seletividade e sensibilidade inerentes às interações anticorpo-antígeno ou enzima-substrato.Os MIP são obtidos por polimerização na presença de uma molécula molde a ser impressa, de tal forma que um esqueleto polimérico é formado ao redor do futuro analito ou de uma molé-cula com estrutura análoga. Após a polimerização a molécula que foi impressa é removida por dissolução ou evaporação (quando são analitos voláteis), revelando sítios de ligação (cavidades) que são complementares em forma e tamanho do analito (Figura 1). Com esta estratégia, o resultado é uma "memória" molecular no polímero, que é apropriada para que ocorra um processo de inclusão reversí-vel e um enriquecimento seletivo do analito. A primeira etapa da síntese consiste em misturar o monômero contendo grupos funcionais complementares àq...

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“…It is also important to note that the oxidation of alcohol groups to carbonyl groups indicates a principal step in the degradation of fats during the human metabolism [4][5][6][7]. In recent years, research efforts were focused on increasing selective activity and reducing the cost in the catalytic processing of compounds in various fields such as fuels, fine chemicals, and pollution reduction [8][9][10][11][12][13]. The development of highly active catalyst for the selective oxidation of alcohols with air in aqueous media plays an essential role in the heterogeneous catalytic process [14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Recyclable Cu(II)-(MAA-EGDMA) catalyst for selective oxidation of alcohols to aldehydes using sodium hypochlorite

Khojasteh

Maleki

2020

Eur J Chem

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Copper(II) α-benzoin oxime complex was synthesized by the reaction between copper(II) benzoate and α-benzoin oxime. The poly methacrylic acid-ethylene glycol dimethacrylate (MAA-EGDMA) was applied as support of copper complex catalyst for oxidation of alcohols to aldehydes using NaClO. The structure and morphology of immobilized Cu(II)-benzoin oxime have been studied by using different analysis including Fourier Transform Infrared (FT-IR) spectroscopy, Scanning Electron Microscopy (SEM) and Thermal Gravimetric Analysis (TGA). The yield of aldehydes was determined by Gas Chromatography (GC) analysis. The immobilized Cu(II)-benzoin oxime indicated a high catalytic activity compared to its absence for the alcohol oxidation with sodium hypochlorite. The effect of the reaction time and temperature, the solvent type, the amounts of catalyst and NaClO were optimized to obtain maximum yield. The prepared catalyst had various benefits such as being inexpensive, environmentally friendly manner, recyclable, reducing the reaction time and increasing the yield. A reaction mechanism is proposed for oxidation of alcohols in the presence of the catalyst.

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Towards bilirubin imprinted poly(methacrylic acid-co-ethylene glycol dimethylacrylate) for the specific binding of α-bilirubin

Cited by 30 publications

References 28 publications

Polyethylenimine‐grafted and HSA‐immobilized poly(GMA–MMA) affinity adsorbents for bilirubin removal

Polyethylenimine‐grafted and HSA‐immobilized poly(GMA–MMA) affinity adsorbents for bilirubin removal

Polímeros biomiméticos em química analítica. Parte 2: aplicações de MIP ("Molecularly Imprinted Polymers") no desenvolvimento de sensores químicos

Recyclable Cu(II)-(MAA-EGDMA) catalyst for selective oxidation of alcohols to aldehydes using sodium hypochlorite

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