The article shows the results of the research in the area of cross-sectoral network interaction of structures in the digital economy. The research sums up the analysis of the up-todate practices of digital twins management in Russia and worldwide and enlarges on the effects of digital twins employed in such economic sectors as automotive industry, healthcare, education, culture, trade, transport and agriculture. The emphasis is made on the big data becoming the major active of modern business. Moreover, they are the data connected within a certain network that may add to the value of a company. The eleven basic principles of cross-sectoral network interaction of structures in the digital economy have been elicited as such reflecting the concept of adding value to business: the principle of consistency; the principle of synergy; the principle of the electronic exchange quality in terms of data and documents exchange in the form of business operations between the structures from different sectors; the principle of automated control; the principle of digital design of management processes; the principle of horizontal and technological cooperation between the partners within the network; the principle of continuous training of staff in the area of digital innovations; the principle of SDM client oriented approach; the principle of procedure standardization; the principle of cross-cultural digital communications; the principle of socially responsible partnership. Conditioned by the rapidly developing digital communications, cross-sectoral cooperation is marked by the transition from the rigid hierarchical structures to the flexible horizontal network structures capable of swiftly adjusting the configuration of their links to the new designs of technologically advanced partnership.