Towards electrochemical surface plasmon resonance sensor based on the molecularly imprinted polypyrrole for glyphosate sensing

Balčiūnas, Domas; Plaušinaitis, Deivis; Ratautaitė, Vilma; Ramanavičienė, Almira; Ramanavičius, Arūnas

doi:10.1016/j.talanta.2022.123252

Cited by 58 publications

(17 citation statements)

References 74 publications

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“…Typically, developing a new diagnostic device takes longer than for a given virus to mutate, thereby decreasing the sensitivity of the antibody-based assay. One long-championed ‘alternative’ to antibodies has been molecular imprinting [22] , [23] ; despite few reported applications for viral antigen detection, the approach has had little impact due to limited capability so far [24] . Current published works utilize the use of on-chip poly- merization methods which are challenging to scale up into sensing technologies capable of addressing pandemic needs.…”

Section: Introductionmentioning

confidence: 99%

Nanoplasmonic biosensor for rapid detection of multiple viral variants in human serum

Bhalla

Payam

Morelli

et al. 2022

Sensors and Actuators B: Chemical

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Section: Introductionmentioning

confidence: 99%

Nanoplasmonic biosensor for rapid detection of multiple viral variants in human serum

Bhalla

Payam

Morelli

et al. 2022

Sensors and Actuators B: Chemical

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“…The primary principle underlying biosensing devices is the conversion of biotarget detection into an analytical signal for further analysis. A variety of molecules including enzymes [ 1 , 2 ], proteins [ 3 , 4 ], antibodies [ 5 , 6 ], and nucleic acids [ 7 , 8 ] can be used as target biomolecules, with electrochemical [ 5 , 9 , 10 ], optical [ 11 ], piezoelectric [ 12 ], surface plasmon resonance [ 13 ], and other methods being commonly used for the analytical signal registration.…”

Section: Introductionmentioning

confidence: 99%

Electrochemical Determination of Interaction between SARS-CoV-2 Spike Protein and Specific Antibodies

Drobysh

Liustrovaitė

Baradokė

et al. 2022

IJMS

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The serologic diagnosis of coronavirus disease 2019 (COVID-19) and the evaluation of vaccination effectiveness are identified by the presence of antibodies specific to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this paper, we present the electrochemical-based biosensing technique for the detection of antibodies specific to the SARS-CoV-2 proteins. Recombinant SARS-CoV-2 spike proteins (rSpike) were immobilised on the surface of a gold electrode modified by a self-assembled monolayer (SAM). This modified electrode was used as a sensitive element for the detection of polyclonal mouse antibodies against the rSpike (anti-rSpike). Electrochemical impedance spectroscopy (EIS) was used to observe the formation of immunocomplexes while cyclic voltammetry (CV) was used for additional analysis of the surface modifications. It was revealed that the impedimetric method and the elaborate experimental conditions are appropriate for the further development of electrochemical biosensors for the serological diagnosis of COVID-19 and/or the confirmation of successful vaccination against SARS-CoV-2.

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“…or bioreceptors (enzymes, nucleic acids, antibodies, etc.) [7][8][9][10]. In general, Ag and Au are widely used as plasmonic materials for SPR sensors.…”

Section: Introductionmentioning

confidence: 99%

Performance Enhancement of SPR Biosensor Using Graphene–MoS2 Hybrid Structure

Cai

Wang

et al. 2022

Nanomaterials

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We investigate a high-sensitivity surface plasmon resonance (SPR) biosensor consisting of a Au layer, four-layer MoS2, and monolayer graphene. The numerical simulations, by the transfer matrix method (TMM), demonstrate the sensor has a maximum sensitivity of 282°/RIU, which is approximately 2 times greater than the conventional Au-based SPR sensor. The finite difference time domain (FDTD) indicates that the presence of MoS2 film generates a strong surface electric field and enhances the sensitivity of the proposed SPR sensor. In addition, the influence of the number of MoS2 layers on the sensitivity of the proposed sensor is investigated by simulations and experiments. In the experiment, MoS2 and graphene films are transferred on the Au-based substrate by the PMMA-based wet transfer method, and the fabricated samples are characterized by Raman spectroscopy. Furthermore, the fabricated sensors with the Kretschmann configuration are used to detect okadaic acid (OA). The okadaic acid–bovine serum albumin bioconjugate (OA-BSA) is immobilized on the graphene layer of the sensors to develop a competitive inhibition immunoassay. The results show that the sensor has a very low limit of detection (LOD) of 1.18 ng/mL for OA, which is about 22.6 times lower than that of a conventional Au biosensor. We believe that such a high-sensitivity SPR biosensor has potential applications for clinical diagnosis and immunoassays.

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Towards electrochemical surface plasmon resonance sensor based on the molecularly imprinted polypyrrole for glyphosate sensing

Cited by 58 publications

References 74 publications

Nanoplasmonic biosensor for rapid detection of multiple viral variants in human serum

Nanoplasmonic biosensor for rapid detection of multiple viral variants in human serum

Electrochemical Determination of Interaction between SARS-CoV-2 Spike Protein and Specific Antibodies

Performance Enhancement of SPR Biosensor Using Graphene–MoS2 Hybrid Structure

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