Towards point of care systems for the therapeutic drug monitoring of imatinib

Pearce, Charles M.; Resmini, Marina

doi:10.1007/s00216-020-02545-4

Cited by 11 publications

(9 citation statements)

References 61 publications

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“…Many studies have highlighted the clinical benefit of TDM for the first tyrosine kinase inhibitor—imatinib [ 19 , 20 , 21 ]. Like many other TKIs, imatinib exhibits large interpatient pharmacokinetic variability with more than ten-fold differences in drug plasma concentration, which sometimes results in therapeutic failures [ 22 , 23 ]. This variation has been linked to multiple genetic factors but may also be influenced by other physiological and environmental factors, such as drug–drug/food interactions and patient adherence [ 24 ].…”

Section: Introductionmentioning

confidence: 99%

“…Clinical data have also shown that the plasma concentration of imatinib is directly linked to therapeutic success; for example, in the case of chronic myeloid leukemia, the concentration needs to be higher than 1000 ng·mL −1 , while for GISTs, the minimum concentration is 1100 ng·mL −1 . Current literature data recommend that the therapeutic dose should not exceed 3000 ng·mL −1 ; however, a systematic analysis of available patient data, where side effects were reported, appears to suggest that a much lower value (closer to 1500 ng·mL −1 ) should be used [ 22 ].…”

Section: Introductionmentioning

confidence: 99%

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Determination of Tyrosine Kinase Inhibitors via Capillary Electrophoresis with Tandem Mass Spectrometry and Online Stacking Preconcentration

Petr

2023

Pharmaceuticals

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Capillary electrophoresis connected with tandem mass spectrometry was employed for the development of a method for determination of various tyrosine kinase inhibitors in plasma samples. A stacking online preconcentration with a 120 cm-long capillary was used for the determination of bosutinib, dasatinib, canertinib, and erlotinib at physiologically relevant concentrations. The optimization included both capillary electrophoresis and mass spectrometry steps. Under optimal conditions, 50 mM formic acid pH 2.5, an injection time of 120 s, and an optimized mass spectrometry set-up (as sheath liquid composition 75:24.9:0.1 (v/v) methanol, water, formic acid, and appropriate conditions for ion transitions), LODs in a range of 3.9–23.0 nmol.L−1 were observed. The method was validated in terms of linearity, limit of detection, limit of quantification, repeatability of migration times and peak area, and recovery using plasma as a matrix for analytes. The results showed that this method has great promise for use in many analytical tasks, e.g., therapeutic drug monitoring.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Determination of Tyrosine Kinase Inhibitors via Capillary Electrophoresis with Tandem Mass Spectrometry and Online Stacking Preconcentration

Petr

2023

Pharmaceuticals

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“…Imatinib drug was approved in anticancer therapy in 2001 [11] and is used to treat certain types of cancer such as chronic myeloid leukaemia [12]. Monitoring of a content of Imatinib in biological samples as blood, plasma or urine is a crucial and essential issue in terms of appropriate selection of a drug dosage, avoiding overdosing, increasing its biological effects and minimising its toxicity.…”

Section: Introductionmentioning

confidence: 99%

Sensitive adsorptive stripping voltammetric procedure of Imatinib determination in spiked urine samples using solid lead microelectrode

Gęca

Korolczuk

2023

Electroanalysis

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This article reports for the first time the application of solid lead microelectrode for organic compound determination. The proposed sensor was used for anticancer drug Imatinib quantification by adsorptive stripping voltammetry. Procedure of Imatinib determination was developed utilizing advantages ensured by solid lead microelectrode: reusability and durability for a long period of time and its ecological character as compared to film electrodes. The detection limit of Imatinib determination was calculated to be 1.9 × 10 À 10 mol L À 1 . The analytical usability of the developed procedure was confirmed by acceptable recoveries of Imatinib determination in spiked urine samples.

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“…while a frequent/near-continuous measurement remains a challenging task in the clinical practice, so far confined to laboratory and at prototype level, with the exclusion of rare exceptions such as the detection of glucose in diabetic patients. The advent of personalised medicine has shown the importance, if not the compelling need, to tailor the right therapeutic strategy for the right person at the right time, and therapeutic drug monitoring (TDM) with POCT devices is becoming more and more important in many pathologies, very often associated to the need of frequent/ near-continuous measurement of the analyte of interest [4][5][6].…”

Section: Introductionmentioning

confidence: 99%

An integrated device for fast and sensitive immunosuppressant detection

et al. 2021

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The present paper describes a compact point of care (POC) optical device for therapeutic drug monitoring (TDM). The core of the device is a disposable plastic chip where an immunoassay for the determination of immunosuppressants takes place. The chip is designed in order to have ten parallel microchannels allowing the simultaneous detection of more than one analyte with replicate measurements. The device is equipped with a microfluidic system, which provides sample mixing with the necessary chemicals and pumping samples, reagents and buffers into the measurement chip, and with integrated thin film amorphous silicon photodiodes for the fluorescence detection. Submicrometric fluorescent magnetic particles are used as support in the immunoassay in order to improve the efficiency of the assay. In particular, the magnetic feature is used to concentrate the antibody onto the sensing layer leading to a much faster implementation of the assay, while the fluorescent feature is used to increase the optical signal leading to a larger optical dynamic change and consequently a better sensitivity and a lower limit of detection. The design and development of the whole integrated optical device are here illustrated. In addition, detection of mycophenolic acid and cyclosporine A in spiked solutions and in microdialysate samples from patient blood with the implemented device are reported. Graphical abstract

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Towards point of care systems for the therapeutic drug monitoring of imatinib

Cited by 11 publications

References 61 publications

Determination of Tyrosine Kinase Inhibitors via Capillary Electrophoresis with Tandem Mass Spectrometry and Online Stacking Preconcentration

Determination of Tyrosine Kinase Inhibitors via Capillary Electrophoresis with Tandem Mass Spectrometry and Online Stacking Preconcentration

Sensitive adsorptive stripping voltammetric procedure of Imatinib determination in spiked urine samples using solid lead microelectrode

An integrated device for fast and sensitive immunosuppressant detection

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