Towards reliable optical label-free point-of-care (PoC) biosensing devices

Holgado, Miguel; Maigler, María V.; Santamaría, Beatriz; Hernández, Ana López; Lavín, Álvaro; Heras, María Fe Laguna; Sanza, Francisco J.; Granados, Daniel; Casquel, Rafael; Portilla, Jorge; Riesgo, Teresa

doi:10.1016/j.snb.2016.06.047

Cited by 23 publications

(28 citation statements)

References 8 publications

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“…1-B). The drying process effect was previously reported as an efficient method to accurately carry out immunoassays where biosensing signals fit properly with the theoretical calculations [7,12,20,21].…”

Section: Methodsmentioning

confidence: 52%

“…High sensitivity optical detection methods are a continuous matter of study, in which scientific community is working persistently to achieve the development of novel biosensing systems with improved performance [1]. This work is specially focused on the field of micro and nano technology, where many optical integrated sensors and biosensors [2,3] have proven to be effective and strong candidates to become the technology on which the diagnosis systems lab-on-a-chip [4] and Point of Care detection devices (PoC) must be based [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

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How the surrounding environment affects the biosensing performance of resonant nanopillars arrays: Under dry conditions or immersed in fluid

Hernández

Casquel

Holgado

et al. 2018

Sensors and Actuators B: Chemical

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In this work we demonstrate the advantage of performing the biosensing process of a refractive index optical biosensor under dry conditions, in comparison with the biosensing structure immersed in fluid. We developed a biosensing experiment over a specific transducer based on resonant nanopillars (R-NPs) arrays. The optical interrogation to monitor the recognition events was firstly performed with the R-NPs in dry, only in contact with the air, and secondly with the R-NPs immersed in water. We observed a significant enhance in the sensitivity of the biosensing curve response for the R-NPs in dry conditions, leading an improvement of the Limit of Detection (LoD) in more than one order of magnitude. These results are also in good correlation with 3D-Finite difference time domain simulations carried out for both fluid conditions. According to this result, any interferometric optical bio-transducer for in-situ diagnosis will improve the sensitivity in case it can operate in dry conditions. Moreover, measuring in simple drops of biological samples, in dry conditions, will be a relevant issue for Point of Care Devices.

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Section: Methodsmentioning

confidence: 52%

Section: Introductionmentioning

confidence: 99%

How the surrounding environment affects the biosensing performance of resonant nanopillars arrays: Under dry conditions or immersed in fluid

Hernández

Casquel

Holgado

et al. 2018

Sensors and Actuators B: Chemical

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show abstract

“…This area can be reduced, but usually increasing the complexity of the setup [55]. Monitoring the change in the total reflected power instead of the position of the resonance is also an interesting option for reducing complexity and total cost of the sensor [60].…”

Section: Discussion On Pros and Cons Of Vertical Sensors: Future Persmentioning

confidence: 99%

“…The combination of the measurement of the optical intensity in a given spectral range with the interferometry in two interferometric sensing cells is a method to enhance the biosensing system as a whole. This interferometric optical detection method (IODM) has been detailed elsewhere [58][59][60], has been patented [61], and is under commercial exploitation by bio optical detection (BioD) [62].…”

Section: Optical Techniquesmentioning

confidence: 99%

“…Several implementations can be carried out, but the one in which the interference of two interferometers is expressed as a variation of the optical power is relevant for the envelopment of reliable point of care and point of need devices (see [60]). In this case, a reference interferometer is interrogated in a given spectral range and compared with a signal interferometer (the one exposed to the accumulation of recognition of biological material).…”

Section: Optical Techniquesmentioning

confidence: 99%

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Engineering vertically interrogated interferometric sensors for optical label-free biosensing

et al. 2020

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In this work, we review the technology of vertically interrogated optical biosensors from the point of view of engineering. Vertical sensors present several advantages in the fabrication processes and in the light coupling systems, compared with other interferometric sensors. Four different interrelated aspects of the design are identified and described: sensing cell design, optical techniques used in the interrogation, fabrication processes, fluidics, and biofunctionalization of the sensing surface. The designer of a vertical sensor should decide carefully which solution to adopt on each aspect to finally integrating all the components in a single platform. Complexity, cost, and reliability of this platform will be determined by the decisions taken on each of the design process. We focus in the research and experience acquired by our group during last years on the field of optical biosensors.

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A new optical interferometric-based in vitro detection system for the specific IgE detection in serum of the main peach allergen

Espinosa

Garrido‐Arandia

Romero-Sahagun

et al. 2020

Biosensors and Bioelectronics

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Towards reliable optical label-free point-of-care (PoC) biosensing devices

Cited by 23 publications

References 8 publications

How the surrounding environment affects the biosensing performance of resonant nanopillars arrays: Under dry conditions or immersed in fluid

How the surrounding environment affects the biosensing performance of resonant nanopillars arrays: Under dry conditions or immersed in fluid

Engineering vertically interrogated interferometric sensors for optical label-free biosensing

A new optical interferometric-based in vitro detection system for the specific IgE detection in serum of the main peach allergen

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