The industrial landscape is undergoing a series of fundamental changes, because of the advances in cutting-edge digital technologies. Under the framework of Industry 4.0 engineers have focused their effort on the development of new frameworks integrating digital technologies such as Big Data Analytics, Digital Twins, Extended Reality, and Artificial Intelligence, to upscale modern manufacturing systems, reduce uncertainties, and cope with the increased market volatility. However, in the upcoming industrial revolution, i.e., Industry 5.0, the research focus will be directed towards the new generation of human operators, the Operator 5.0. The purpose of this paper is to investigate the key technologies that will be the drivers towards the realization of the Operator 5.0 and to highlight the key challenges. Additional contribution is the proposal of a framework for the training and support of shopfloor technicians based on the utilization of Mixed Reality for manufacturing processes.