Toxic effect of Moringa peregrina seeds on histological and biochemical analyses of adult male Albino rats

Abstract

Graphical abstract

Effect of Feeding of Moringa oleifera Seed Meal as a New Protein Source on Performance, Digestibility and Blood Constituents of Male Goats Under Desert Conditions

“…Also, other phytoconstituents such as β-sitosterol could be the major cholesterol reducing components of Moringa oleifera leaf ethanol extract as it may work singly or in synergy with other bioactive agents (Pop et al, 2018), which may be the cause improvement of lipid profile in this study. Similar results are recorded in rats administered different levels of dry seed of M. peregrina by El-Hak et al (2018).…”

“…Regarding to the serum liver enzymes, goats fed MOSM at the levels of 25 and 50% (G2&G3) showed significant decreased of the ALT and AST activities during the different periods. This effect could be attributed to its content of vitamins, carotenoids and phytocompounds; polyphenols, phenolic acids, flavonoids, alkaloids, glucosinolates, isothiocyanates, tannins and saponins which have been proved to have potent antioxidant properties and other biological activities (Zade et al, 2013;Idoko et al, 2017;El-Hak et al, 2018;Atta et al, 2019).…”

<i>In Vitro</i> Macrophage Nitric Oxide and Interleukin-1 Beta Suppression by Moringa peregrina Seed

“…Although M. peregrina seeds have been reported to be widely used in traditional medicine, only a few scientific studies exist on its therapeutic efficacy and mechanism of action. 11,14,18,19 As a follow-up to those studies, our aim was to investigate the effects of MPSE, which may be considered a potential antiinflammatory drug, on NO and IL-1β in LPS-induced J774A.1 macrophage cells. Macrophages are the predominant cells in immunologic responses.…”

“…It is also administered to pregnant women to facilitate fetus delivery. 11 Pharmacological studies have reported the validation of this plant for antiinflammatory, antimicrobial, antiulcer, and antioxidant use. 10,12 M. peregrina seed oil contains high amounts of oleic acid, linoleic acid, tocopherols, and phenolic compounds, which help to reduce inflammation.…”

Histological study on the acute injection of aluminum sulfate on different organs of rats

“…Then, Rats were sacrificed by decapitation. Part of the forebrains, heart, lung, liver, kidney, spleen, stomach, small intestine epidydimis, testes, uterus and ovary were isolated and fixed in 10 % of phosphate buffered formalin for 2 days for histological preparation for light microscopic examination [EL-Hak, Moustafa [15,16,17]. 0.5 g of each rat tissue was used for the assessment of aluminum concentrations [18].…”