Toxic Effects in Man of Overdosage with Sodium Sulfapyridine

Pharmacology of Sulphonamides: Recent Work

“…Similar symptoms of convulsions and rigidity (followed by recovery) have occurred in a 3-year-old child who took 6 g. sulphanilamide (Reed, 1944). A case has also been recorded (Cutts and Bowman, 1941) of a man who was given by mistake 30 g. sodium sulphapyridine during a 10-hour period. The main nervous symptoms were restlessness, vomiting, and hiccup, but no convulsions, twitching, or loss of mental lucidity.…”