No abstract

No abstract

adenopathy, and lacrimation constitute a syndrome frequently found in drug hypersensitivity and should therefore awaken suspicion. It is necessary to know, in addition to these findings, that p-aminosalicylic acid hypersensitivity can cause the appearance of atypical lymphocytes and also evidence of liver damage. If the clinician is aware of these facts, he will recognize or suspect p-aminosalicylic acid hypersensitivity and promptly stop administration of the drug. Proof that the syndrome described is a hypersensitivity reaction is afforded by the fact that it recurs even after a long interval on readministration of very small doses of the drug.

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Sixty-nine hospitalized who rest and lasting at least 15 minutes, and whose electrocardiographic changes were limited to deeply inverted T waves predominantly in the precordial leads, were selected from a large series of patients. The hospital course and electrocardiographic changes of these patients were studied. After an average follow-up period of 4 years, approximately half the patients were still able to work. Postmortem studies on 11 patients revealed extensive sclerosis of the coronary arteries in all.