Toxic Effects in Women Exposed to Industrial Rubber Solutions

Browning, Ethel

doi:10.1136/bmj.1.4340.349

Cited by 14 publications

(3 citation statements)

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“…The results from this study have been corroborated by more recent studies (Aksoy, 1988;Rothman et al, 1996;Yin et al, 1987). However, other studies have found no significant association between benzene exposure and decreased lymphocyte count (Aksoy et al, 1971;Collins et al, 1997;Doskin, 1971;Hamilton-Paterson and Browning, 1944;Hernberg et al, 1966). One study observed that lymphocyte count was the only hematology value affected at exposures less than 31 ppm per day (Rothman et al, 1996).…”

Section: Discussionsupporting

confidence: 89%

A hematology surveillance study of petrochemical workers exposed to benzene

Tsai

Fox

Ransdell

et al. 2004

Regulatory Toxicology and Pharmacology

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Section: Discussionsupporting

confidence: 89%

A hematology surveillance study of petrochemical workers exposed to benzene

Tsai

Fox

Ransdell

et al. 2004

Regulatory Toxicology and Pharmacology

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“…Similarly, Savilahti (1956) has found eosinophil levels ranging between 6 and 15-5% in 18 of a series of 147 individuals exposed to benzene. On the other hand, Hamilton-Paterson and Browning (1944) and Goldwater (1941) have not encountered eosinophilia in their series. According to our results 2-75 % eosinophilia is an inconstant finding of the early stage of chronic benzene poisoning.…”

Section: Results and Commentsmentioning

confidence: 94%

Haematological effects of chronic benzene poisoning in 217 workers

Aksoy

Dinçol

Akgün

et al. 1971

Occupational and Environmental Medicine

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. Brit. J. industr. Med., 28, 296-302. Haematological effects of chronic benzene poisoning in 217 workers. A haematological study consisting of the determination of RBC, WBC, PCV, platelets, and differential counts was carried out, together with bone marrow puncture and haemoglobin analyses in appropriate cases, on a control population of 100 normal people and on 217 male labourers, 95% of whom worked with solvents containing benzene in small shops manufacturing shoes under unhygienic conditions. The concentration of benzene in the workplaces ranged between 30 and 210 p.p.m., and the period of exposure between 3 months and 17 years.In 51 of the 217 workers (23 50%) haematological abnormalities attributable to chronic benzene poisoning were detected. Thus, leucopenia was present in 9 70 %, thrombocytopenia in 1-84%, leucopenia associated with thrombocytopenia in 4-6%, pancytopenia in 2-76%, acquired pseudo-Pelger-Huet anomaly in 0-46%, lymphocytosis in 0-46 %, giant platelets in 0-46%, eosinophilia in 2-30%, basophilia in 0-46%, and eosinophilia associated with basophilia in 0*46% (the maximum normal levels for eosinophils and basophils were 8% and 2 % respectively).Acquired pseudo-Pelger-Huet anomaly was detected in a worker with heterozygous betathalassaemia (HbA2 4-1 % and HbF 8-7%) in whom the only effect of benzene was on the leucocyte nuclei, all other haematological values being within normal limits. On the other hand, in 33-1 % of the workers the haemoglobin was less than 12 g/100 ml and in 32-7% the PCV was less than 40 % with the MCV ranging between 86 and 96 ,um3. In none of them did MCV exceed 100 ,um3. Thirty-on-per cent. of these anaemic workers were treated with adequate doses of oral iron, which resulted, in all cases, in a complete disappearance of the anaemia. Therefore, it is difficult to attribute this anaemia to the effect of benzene alone.Thus it is concluded that benzene exerts its harmful effect, primarily on the leucocytes, with eosinophilia and basophilia as inconstant findings, secondarily on the platelets causing thrombocytopenia, and finally on all three series giving rise to pancytopenia.

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“…Recently, we observed a decreased absolute lymphocyte count among healthy workers with moderate-tohigh exposures to benzene compared with nonexposed controls in Shanghai (107). Though the finding of benzene-associated lymphocytopenia has been confirmed by some (108), others have failed to find this result (109,110). However, administration of benzene to rats, mice, and rabbits has been shown to produce a dose-dependent decrease in the number of lymphocytes, which may precede the drop in levels of other blood cells (111).…”

Section: Discussionmentioning

confidence: 75%