Toxic Effects of Marijuana on the Cardiovascular System

Pratap, Balaji; Korniyenko, Aleksandr

doi:10.1007/s12012-011-9150-y

Cited by 50 publications

(34 citation statements)

References 44 publications

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“…29 This rise in norepinephrine increases myocardial oxygen demand and reduced left ventricular ejection time, thereby lowering the threshold for angina and peripheral vascular resistance in skeletal muscles. 30 In addition, the increased carbon monoxide exposure from marijuana smoking results in even higher blood levels of carboxyhemoglobin than does smoking standard cigarettes. 31 …”

Section: Discussionmentioning

confidence: 99%

Marijuana use and long-term mortality among survivors of acute myocardial infarction

Frost

Mostofsky

Rosenbloom

et al. 2013

American Heart Journal

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Background Smoking marijuana has been reported to increase risk of myocardial infarction (MI) immediately after use, but less is known about the long-term impact of marijuana use among patients with established coronary disease. Methods The Determinants of MI Onset Study (MIOS) is a multicenter inception cohort study of MI patients enrolled in 1989–1996 and followed for mortality using the National Death Index. In an initial analysis of 1935 MI survivors followed for a median of 3.8 years, we found an increased mortality rate among marijuana users. The current paper includes 3886 MIOS patients followed for up to 18 years. We used Cox proportional hazards models to calculate the hazard ratio and 95% confidence interval for the association between marijuana use and mortality and a propensity score matched analysis to further control confounding. Results Over up to 18 years of follow-up, 519 patients died, including 22 of the 109 reporting marijuana use in the year prior to their MI. There was no statistically significant association between marijuana use and mortality. Compared to non-users, the mortality rate was 29% higher (95% confidence interval 0.81 to 2.05, p=0.28) among those reporting any marijuana use. Conclusions Habitual marijuana use among patients presenting with acute MI was associated with an apparent increased mortality rate over the following 18 years that did not reach nominal statistical significance. Larger studies with repeated measures of marijuana use are needed to definitively establish whether there are adverse cardiovascular consequences of smoking marijuana among patients with established coronary heart disease.

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Section: Discussionmentioning

confidence: 99%

Marijuana use and long-term mortality among survivors of acute myocardial infarction

Frost

Mostofsky

Rosenbloom

et al. 2013

American Heart Journal

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“…K2 has multiple known side effects, and serious events, including ischemic stroke, have been reported. 2 Although there are reports of adverse cardiovascular effects secondary to cannabis or synthetic cannabinoid use, including myocardial infarction (MI), arrhythmias, and sudden death in adults, [3][4][5][6][7][8][9] data on the cardiac effects of K2 in pediatrics is limited. [10][11][12] We report a series of pediatric patients who were seen at a tertiary care center over a 2-year period with evidence of varying degrees of myocardial injury secondary to the use of K2.…”

mentioning

confidence: 99%

Myocardial Ischemia Secondary to Synthetic Cannabinoid (K2) Use in Pediatric Patients

Clark

Georgekutty

Berul

2015

The Journal of Pediatrics

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“…A Brugada-like effect was reported to be associated to cannabis intoxication as described with cocaine abuse [50][51][52]. This ECG pattern is believed to be related to a partial sodium channel antagonist activity.…”

Section: Sodium Channel Blockadementioning

confidence: 98%

Drug Abuse-Induced Cardiac Arrhythmias: Mechanisms and Management

Ouali¹,

Guermazi²,

Guermazi³

et al. 2018

Cardiac Arrhythmias

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Toxicomania is a worldwide emerging problem threatening young population. Several reports highlighted its hazardous cardiovascular effects. Sudden cardiac death secondary to cardiac arrhythmias is the most occupying issue. Different forms of cardiac rhythm disorders may be induced by illicit drug abuse according to the type of drug and the mechanism involved. In this review, we exposed the main ventricular and supraventricular arrhythmia complicating the common recreational drugs, and we explained their different mechanisms as well as the particularities of management.

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Toxic Effects of Marijuana on the Cardiovascular System

Cited by 50 publications

References 44 publications

Marijuana use and long-term mortality among survivors of acute myocardial infarction

Marijuana use and long-term mortality among survivors of acute myocardial infarction

Myocardial Ischemia Secondary to Synthetic Cannabinoid (K2) Use in Pediatric Patients

Drug Abuse-Induced Cardiac Arrhythmias: Mechanisms and Management

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