Toxic Effects of Stable Strontium in Young Pigs

Bartley, J. C.; Reber, Elwood F.

doi:10.1093/jn/75.1.21

Cited by 35 publications

(8 citation statements)

References 10 publications

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“…Animal studies have suggested that Sr is not effective, and may even be counterproductive, if Ca intake is inadequate. 21,22 We therefore hypothesize that Ca supplies nutrition for bone, and the occurrence of synergistic effects of Sr increases bone formation activity. Both in vitro and in vivo experiments have shown that SR inhibits bone resorption and stimulates bone formation, leading to increased matrix deposition.…”

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confidence: 99%

Strontium–calcium coadministration stimulates bone matrix osteogenic factor expression and new bone formation in a large animal model

Chiu

et al. 2009

Journal Orthopaedic Research

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Strontium (Sr) has become increasingly attractive for use in the prevention and treatment of osteoporosis by concomitantly inhibiting bone resorption and enhancing bone formation. Strontium shares similar chemical, physical, and biological characteristics with calcium (Ca), which has been widely used as a dietary supplement in osteoporosis. However, the effects of Sr-Ca coadministration on bone growth and remodeling are yet to be extensively reported. In this study, 18 ovariectomized goats were divided into four groups: three groups of five goats each treated with 100 mg/kg/day Ca, Ca plus 24 mg/kg/day Sr (Ca þ 24Sr), or Ca plus 40 mg/kg/day Sr (Ca þ 40Sr), and three untreated goats fed low calcium feed. Serum Sr levels increased 6-and 10-fold in the Ca þ 24Sr and Ca þ 40Sr groups, respectively. Similarly, Sr in the bone increased four-and sixfold in these two groups. Sr-Ca coadministration considerably increased bone mineral apposition rate (MAR). The expression of insulin-like growth factor (IGF)-1 and runt-related transcription factor 2 (Runx2) was significantly upregulated within the Ca þ 40Sr treatment group; tumor necrosis factor (TNF)-agr; expression was significantly downregulated in the Ca and Ca þ 40Sr groups. The results indicate that Sr-Ca coadministration increases osteogenic gene expression and stimulates new bone formation.

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confidence: 99%

Strontium–calcium coadministration stimulates bone matrix osteogenic factor expression and new bone formation in a large animal model

Chiu

et al. 2009

Journal Orthopaedic Research

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“…In several species, high dietary strontium has been shown to produce skeletal defects analogous in many respects to vitamin D3-deficiency rickets (1)(2)(3)(4). On the basis of the in vivo and in vitro experiments of Sobel and co-workers (2, 5 , 6), it was suggested that a direct inhibition of the calcification mechanism was the cause of the disease.…”

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Strontium Inhibition of Vitamin D3-Induced Calcium-Binding Protein (CaBP) and Calcium Absorption in Chick Intestine

Corradino¹,

Wasserman²

1970

Experimental Biology and Medicine

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“…1). In addi tion, no adverse effects were found in the extremities, such as an inability to stand or paralysis (14).…”

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confidence: 81%

Effects of Strontium on Calcium Metabolism in Rats II. Strontium Prevents the Increased Rate of Bone Turnover in Ovariectomized Rats

Morohashi

Sano

Yamada

1995

Japanese Journal of Pharmacology

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ABSTRACT-Strontium at low doses has been used to treat osteoporosis. However, excessive doses can disturb calcium metabolism. The aim of the present study was to determine a dose that does not have any significant toxic effects on calcium contents in bone and calcium metabolism, and, consequently, to distinguish between pharmacological and toxic doses in rats. The rats were divided into a control, 0.05% Sr, 0.10%-Sr and 0.50%-Sr groups (strontium intake approx. 0, 87.5, 175 and 875 pcmol/day, respectively). All of the rats were pair-fed their respective diets containing various doses of strontium in single metabolic cages from when they were 36 to 63 days old. When the rats were 60 days old, bone formation, bone resorp tion, calcium balance and intestinal calcium absorption were calculated as calcium metabolic parameters over a 3-day period using calcium balance and kinetic studies. At the age of 64 days, the rats were sacrificed under anesthesia, and the femur and blood were collected. Calcium and strontium levels in the bone and serum were then measured. In the strontium groups that received less than 175 pmol/day, none of the calcium metabolic parameters were significantly affected. However, the calcium contents in the bone were significantly increased in the group that received 87.5 pmol/day group. On the other hand, in the group that received the highest dose of strontium (875 pmol/day), all of the calcium metabolic parameters measured were markedly suppressed. A decrease in calcium level in both the bone and serum was also observed. These results suggest that strontium at doses of less than 175 , imol per day does not have a toxic effect on calcium contents in bone or calcium metabolism in rats, and a dose of 87.5 pmol/day may be adopted for future evaluations of the efficacy of strontium in various experimental skeletal diseases.

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Toxic Effects of Stable Strontium in Young Pigs

Cited by 35 publications

References 10 publications

Strontium–calcium coadministration stimulates bone matrix osteogenic factor expression and new bone formation in a large animal model

Strontium–calcium coadministration stimulates bone matrix osteogenic factor expression and new bone formation in a large animal model

Strontium Inhibition of Vitamin D3-Induced Calcium-Binding Protein (CaBP) and Calcium Absorption in Chick Intestine

Effects of Strontium on Calcium Metabolism in Rats II. Strontium Prevents the Increased Rate of Bone Turnover in Ovariectomized Rats

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