Toxicity and proteolysis in germfree rats with thermal burns

Zaets, T. L.; Koryakina, Irina; Kotkina, T. I.; Podoprigora, G. I.

doi:10.1007/bf00785700

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“…In addition, the effects of contrykal on KKS can be realized via inhibition of the synthesis and release of histamine and serotonin and via inhibition of proteolytic enzymes [3,4], the content of which was shown to change [5,7]. We have previously found that long-term (10 days) FR depleted KKS, and that the deficit of its principal components resulted from reduced kinin production [7].…”

Section: Resultsmentioning

confidence: 98%

Effect of contrykal on lymph and blood kallikrein-kinin systems and contractile activity of lymphatic microvessels during fever

Mukhutdinova¹

1999

Bull Exp Biol Med

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Contrykal prevented activation of the kallikrein-kinin system in the lymph and blood during short-term fever, reduced it during long-term fever, and increased contractile activity of the walls and valves of lymphatic microvessels, thus accelerating lymph flow. Key Words: fever; conttykal; lymph; kallikrein-kinin systemFebrile reaction (FR) is accompanied by considerable changes in the functional activity of organs and systems and homeostatic disturbances. An important role in the homeostasis is played by the lymphatic system, which appropriate resorption and transport functions predetermine many qualitative and quantitative changes in metabolic processes at the level of the microcirculatory bed. Taking into account transcapillary exchange of the kallikrein-kinin system (KKS) components (blood--tissue fluid--lymph--blood), we revealed phase shifts in their content in the lymph flowing off from different regions and in the peripheral blood during FR of different duration [7]. It is known, that the kinin system plays an important role in the central mechanisms of fever.The present study was aimed at investigation of the effect of contrykal on the content of KKS components in the lymph and blood and contractile activity of lymphatic microvessels (LM) during FR. MATERIALS AND METHODSExperiments were carried out on 30 Chinchilla rabbits (2.5-4.2 kg) and 23 albino rats (150-200 g). Febrile reaction was induced as described previously [6,7]. In rabbits, the lymph (from the thoracic duct) and blood (from femoral vein) were taken during FR rise and Department of Pathophysiology, Kasan' State Medical University decay after a single injection of pyrogenal and on the next day after 3 or 5 daily injections. The samples were analyzed for the content of kininogenin [10], prekallikrein [2], kallikrein [12], and free kinins [11] and kininase activity [ 12]. Spontaneous formation and destruction of kinins in samples was prevented. Contrykal in a daily dose of 3000 antitrypsin U/kg in 20 ml apyrogenic saline was intravenously infused 30 min after pyrogenal injection.In rats, contractile activities of the walls and valvules of mesenteric LM were studied by vital microscopy [1,13] during the rise and decay of FR caused by single injection ofpyrogenal after local application of contrykal (100 antitrypsin U in 0.2 ml apyrogenic saline). In control rats, the preparation was administered by the same route. The data were analyzed statistically.

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Section: Resultsmentioning

confidence: 98%

Effect of contrykal on lymph and blood kallikrein-kinin systems and contractile activity of lymphatic microvessels during fever

Mukhutdinova¹

1999

Bull Exp Biol Med

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show abstract

Toxicity and proteolysis in germfree rats with thermal burns

Cited by 1 publication

References 1 publication

Effect of contrykal on lymph and blood kallikrein-kinin systems and contractile activity of lymphatic microvessels during fever

Effect of contrykal on lymph and blood kallikrein-kinin systems and contractile activity of lymphatic microvessels during fever

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