Toxicity, Bioaccumulation, and Biotransformation of Silver Nanoparticles in Marine Organisms

Wang, Huanhua; Ho, Kay T.; Scheckel, Kirk G.; Wu, Fengchang; Cantwell, Mark G.; Katz, David R.; Horowitz, Doranne Borsay; Boothman, Warren S.; Burgess, Robert M.

doi:10.1021/es502976y

Cited by 66 publications

(25 citation statements)

References 28 publications

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“…Coleman et al [45] concluded in their study that neither the coating nor the size of AgNPs influenced the bioaccumulation factors of the Ag from the sediment to L. variegatus. For the marine benthic polychaete Nereis virens, bioaccumulation was influenced by the AgNP coating agent [46]. In the present study, the PVP-coating on AgNPs was found to promote the bioaccumulation of AgNP-originated Ag.…”

Section: Total Body Burdens Of Ag In L Variegatussupporting

confidence: 47%

Partitioning of nanoparticle-originated dissolved silver in natural and artificial sediments

Rajala

Vehniäinen

Väisänen

et al. 2017

Environmental Toxicology and Chemistry

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Sediments are believed to be a major sink for silver nanoparticles (AgNPs) in the aquatic environment, but there is a lack of knowledge about the environmental effects and behavior of AgNPs in sediments. The release of highly toxic Ag through dissolution of AgNPs is one mechanism leading to toxic effects in sediments. We applied an ultrasound-assisted sequential extraction method to evaluate the dissolution of AgNPs and to study the partitioning of dissolved Ag in sediments. Silver was spiked into artificial and 2 natural sediments (Lake Höytiäinen sediment and Lake Kuorinka sediment) as silver nitrate (AgNO ), uncoated AgNPs, or polyvinylpyrrolidone-coated AgNPs (PVP-AgNPs). In addition, the total body burdens of Ag in the sediment-dwelling oligochaete Lumbriculus variegatus were assessed over a 28-d exposure period. The dissolution rate was found to be similar between the uncoated AgNP and PVP-AgNP groups. In all sediments, dissolved Ag was mainly bound to the residual fraction of the sediment, followed by iron and manganese oxides or natural organic matter. In Lake Kuorinka sediment, dissolved Ag that originated from PVP-AgNPs was relatively more bioaccessible, also resulting in higher total body burden in L. variegatus than that from uncoated AgNPs or AgNO . In artificial sediment and Lake Höytiäinen sediment, AgNO was significantly more bioaccessible than AgNPs. Our results highlight the importance of sediment properties and AgNP surface chemistry when evaluating the environmental exposure of AgNPs. Environ Toxicol Chem 2017;36:2593-2601. © 2017 SETAC.

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Section: Total Body Burdens Of Ag In L Variegatussupporting

confidence: 47%

Partitioning of nanoparticle-originated dissolved silver in natural and artificial sediments

Rajala

Vehniäinen

Väisänen

et al. 2017

Environmental Toxicology and Chemistry

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“…Therefore, the increasing use and growing production of AgNPs, as potential sources of Ag contamination, raise public concerns about the environmental toxicity of Ag ( Li et al, 2018a ). Previous research has demonstrated that AgNPs can precipitate in marine sediments, be ingested by benthic organisms (such as benthic invertebrate species), enter and be transferred from one trophic level to the next via the food chain, and thereby cause negative effects on the animals at different trophic levels, such as algae, invertebrates and fishes ( Buffet et al, 2014 ; Farre et al, 2009 ; Gambardella et al, 2015 ; Huang, Cheng & Yi, 2016b ; Wang et al, 2014 ). Previous studies have demonstrated that AgNPs are toxic to all tested marine organisms in a dose-dependent manner, indicating that AgNPs may have negative effects on marine organisms at different trophic levels of the marine environment.…”

Section: Introductionmentioning

confidence: 99%

Th2 cytokine bias induced by silver nanoparticles in peripheral blood mononuclear cells of common bottlenose dolphins (Tursiops truncatus)

Wang

Chang

et al. 2018

PeerJ

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BackgroundSilver nanoparticles (AgNPs) have been widely used in many commercial products due to their excellent antibacterial ability. The AgNPs are released into the environment, gradually accumulate in the ocean, and may affect animals at high trophic levels, such as cetaceans and humans, via the food chain. Hence, the negative health impacts caused by AgNPs in cetaceans are of concern. Cytokines play a major role in the modulation of immune system and can be classified into two types: Th1 and Th2. Th1/Th2 balance can be evaluated by the ratios of their polarizing cytokines (i.e., interferon [IFN]-γ/Interleukin [IL]-4), and animals with imbalanced Th1/Th2 response may become more susceptible to certain kinds of infection. Therefore, the present study evaluated the in vitro cytokine responses of cetacean peripheral blood mononuclear cells (cPBMCs) to 20 nm citrate-AgNPs (C-AgNP20) by quantitative reverse transcriptase polymerase chain reaction (qRT-PCR).MethodsBlood samples were collected from six captive common bottlenose dolphins (Tursiops truncatus). The cPBMCs were isolated and utilized for evaluating the in vitro cytokine responses. The cytokines evaluated included IL-2, IL-4, IL-10, IL-12, interferon (IFN)-γ, and tumor necrosis factor (TNF)-α. The geometric means of two housekeeping genes (HKGs), glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and β2-microglobulin (B2M), of each sample were determined and used to normalize the mRNA expression levels of target genes.ResultsThe ratio of late apoptotic/necrotic cells of cPBMCs significantly increased with or without concanavalin A (ConA) stimulation after 24 h of 10 µg/ml C-AgNP20 treatment. At 4 h of culture, the mRNA expression level of IL-10 was significantly decreased with 1 µg/ml C-AgNP20 treatment. At 24 h of culture with 1 µg/ml C-AgNP20, the mRNA expression levels of all cytokines were significantly decreased, with the exceptions of IL-4 and IL-10. The IFN-γ/IL-4 ratio was significantly decreased at 24 h of culture with 1 µg/ml C-AgNP20 treatment, and the IL-12/IL-4 ratio was significantly decreased at 4 or 24 h of culture with 0.1 or 1 µg/ml C-AgNP20 treatment, respectively. Furthermore, the mRNA expression level of TNF-α was significantly decreased by 1 µg/ml C-AgNP20 after 24 h of culture.DiscussionThe present study demonstrated that the sublethal dose of C-AgNP20 (≤1 µg/ml) had an inhibitory effect on the cytokine mRNA expression levels of cPBMCs with the evidence of Th2 cytokine bias and significantly decreased the mRNA expression level of TNF-α. Th2 cytokine bias is associated with enhanced immunity against parasites but decreased immunity to intracellular microorganisms. TNF-α is a contributing factor for the inflammatory response against the infection of intracellular pathogens. In summary, our data indicate that C-AgNP20 suppresses the cellular immune response and thereby increases the susceptibility of cetaceans to infection by intracellular microorganisms.

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“…This study demonstrates the potential for ENMs to persist in biological organisms. Further, potential bioaccumulation of ENM in aquatic organisms and environments (Gagne et al, 2013; Wang et al, 2014) as well as contamination of drinking water under certain conditions (Troester et al, 2016) may result in prolonged exposure conditions, which might produce persistent phagolysosomal membrane damage and promote disease.…”

Section: Cathepsinsmentioning

confidence: 99%

Engineered nanomaterial-induced lysosomal membrane permeabilization and anti-cathepsin agents

Bunderson-Schelvan

Holian

Hamilton

2017

Journal of Toxicology and Environmental Health, Part B

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Engineered nanomaterials (ENMs), or small anthropogenic particles approximately < 100 nm in size and of various shapes and compositions, are increasingly incorporated into commercial products and used for industrial and medical purposes. There is an exposure risk to both the population at large and individuals in the workplace with inhalation exposures to ENMs being a primary concern. Further, there is increasing evidence to suggest that certain ENMs may represent a significant health risk, and many of these ENMs exhibit distinct similarities with other particles and fibers that are known to induce adverse health effects, such as asbestos, silica, and particulate matter (PM). Evidence regarding the importance of lysosomal membrane permeabilization (LMP) and release of cathepsins in ENM toxicity has been accumulating. The aim of this review was to describe our current understanding of the mechanisms leading to ENM-associated pathologies, including LMP and the role of cathepsins with a focus on inflammation. In addition, anti-cathepsin agents, some of which have been tested in clinical trials and may prove useful for ameliorating the harmful effects of ENM exposure are examined.

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Toxicity, Bioaccumulation, and Biotransformation of Silver Nanoparticles in Marine Organisms

Cited by 66 publications

References 28 publications

Partitioning of nanoparticle-originated dissolved silver in natural and artificial sediments

Partitioning of nanoparticle-originated dissolved silver in natural and artificial sediments

Th2 cytokine bias induced by silver nanoparticles in peripheral blood mononuclear cells of common bottlenose dolphins (Tursiops truncatus)

Engineered nanomaterial-induced lysosomal membrane permeabilization and anti-cathepsin agents

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