Toxicity of Crataegus (Hawthorn) Extract (WS 1442)

Schlegelmilch, Ronald; Heywood, R.

doi:10.3109/10915819409140991

Cited by 24 publications

(10 citation statements)

References 13 publications

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“…56 In the same context, experiments in rats and mice showed that the hydroalcoholic extract of leaves and flowers can be administered up to 3000 mg/kg without any mortality or abnormal symptoms. 57 It was also demonstrated that CABAE administration significantly and dose-dependently protected against castor oil-induced hypersecretion by inhibiting all studied diarrhea parameters (frequency and severity of diarrhea, onset of the first defecation, number of wet and total number of stools). Castor oil-induced intestinal hypersecretionis a well-known model of acute diarrhea 9 acts via its main compound, ricinoleic acid.…”

Section: Discussionmentioning

confidence: 85%

Protective effects of Crataegus azarolus L. berries aqueous extract against castor oil–induced diarrhea, oxidative stress, and inflammation in rat

Sammari

Jedidi

Selmi

et al. 2020

Neurogastroenterology Motil

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Background: Diarrhea is a multifactorial gastrointestinal disorder responsible for about 5 million deaths annually. The chemical composition, the antioxidant activity of Crataegus azarolus berries aqueous extract (CABAE) as well as its protective effects against castor oil-induced diarrhea, oxidative stress, and inflammation in rat were studied.Methods: Sixty male rats were used and divided into six groups of ten animals in each: Control (C), castor oil (CO), CO+various doses of CABAE (100, 200, and 400 mg/kg b.w., p.o.), and CO+loperamide (LOP, 10 mg/kg b.w., p.o.).

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Section: Discussionmentioning

confidence: 85%

Protective effects of Crataegus azarolus L. berries aqueous extract against castor oil–induced diarrhea, oxidative stress, and inflammation in rat

Sammari

Jedidi

Selmi

et al. 2020

Neurogastroenterology Motil

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“…But Trials have evaluated dosages ranging from 160 to 1800 mg/day standardized extracts in divided doses over 2 to 24 weeks (Schlegelmilch and Heywood, 1994). Minimum effective doses are suggested to be standardized extract 100 (Shatoor, 2011) and 300 mg (Schlegelmilch and Heywood, 1994) daily. Crataegus is reportedly toxic in high doses; low doses of Crataegus usually lack adverse effects.…”

Section: Discussionmentioning

confidence: 99%

Effect of Crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters in male rats

et al. 2019

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“…Like the other lymphatic organs, it gives rise to lymphocytes that pass into the circulating blood. Because of its location in the bloodstream, the spleen responds very quickly to the antigens that invade the blood, being a phagocytic and immunological filter, as well as a large producer of antibodies [23,33].…”

Section: Discussionmentioning

confidence: 99%

Hepatic and splenic cytotoxic evaluation after Crataegus oxyacantha fruit extract administration on mice

Santos¹,

Oliveira²,

Camargo‐Mathias³

et al. 2019

J Histol Histopathol

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The plant Crataegus oxyacantha L., Rosaceae, also known as white hawthorn or hawthorn, is originally native to Europe, North America and Asia, but can also be found in other continents and has been widely used due to its potential pharmacological effects, such as cardiotonic, anti-oxidant, hypolipidemic, antiinflammatory, sedative, among others. Considering the importance of C. oxyacantha as a natural alternative medicine, and the lack of studies involving its cellular toxicity, the objective of this study was to analyze the morpho-histological effects of C. oxyacantha fruit extract in the liver and spleen cells of mice supplemented with 50 (I), 100 (II) or200 mg/kg (III) of extract, in order to evaluate its cytotoxic effects. The liver of the individuals in group I showed no damage. Individuals in group II presented liver in the early stages of tissue and cytoplasmic disorganization. Those of group III suffered major histological alterations such as extensive cytoplasmic disorganization, appearance of vacuoles and increased sinusoidal capillaries, and large amounts of Kupffer cells. On the other hand, the spleen was not histologically modified after the treatments, maintaining its architecture as in the control group. Histochemical analyzes revealed alteration in the liver only, both in the amount of polysaccharides and lipids. It can be concluded that supplementation with C. oxyacantha fruit extract in higher doses leads to tissue disorganization in the liver of mice that indicates the need for caution with continuous and/or high doses use of this plant.

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Toxicity of Crataegus (Hawthorn) Extract (WS 1442)

Cited by 24 publications

References 13 publications

Protective effects of Crataegus azarolus L. berries aqueous extract against castor oil–induced diarrhea, oxidative stress, and inflammation in rat

Protective effects of Crataegus azarolus L. berries aqueous extract against castor oil–induced diarrhea, oxidative stress, and inflammation in rat

Effect of Crataegus extract supplementation on diabetes induced memory deficits and serum biochemical parameters in male rats

Hepatic and splenic cytotoxic evaluation after Crataegus oxyacantha fruit extract administration on mice

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