Toxicity of formaldehyde vapor in B6C3F1 mice exposed for 13 weeks

Proliferative and Nonproliferative Lesions of the Rat and Mouse Respiratory Tract

“…There is no evidence that respiratory epithelial metaplasia is preneoplastic.The normal extension of olfactory epithelium into the anterior region of the dorsal meatus may vary with age and can be possibly strain dependent. (Belinsky et al 1987;Boorman, Morgan, and Uraih 1990;Brown 1990;Dungworth, Ernst, et al 1992;Dungworth et al 2001;Gaskell 1990;Jiang, Morgan, and Beauchamp 1986;Monticello, Morgan, and Uraih 1990;Morgan 1991;Nagano et al 1988) Hyperplasia, Squamous Cell ( Figure 34) (Belinsky et al 1987;Boorman, Morgan, and Uraih 1990;Brown 1990;Brown et al 1991;Buckley et al 1985;Dungworth et al 2001;Feron, Woutersen, and Spit 1986;Gaskell 1990;Gopinath, Prentice, and Lewis 1987;Harkema 1990;Jiang, Morgan, and Beauchamp 1986;Maronpot et al 1986;Monticello, Morgan, and Uraih 1990;Morgan 1991;Quest et al 1984;Renne et al 1986;Reznik, Stinson, and Ward 1980;Reznik, Schuller, and Stinson 1994;Reznik-Schüller 1983a;Reznik-Schüller 1983b;Rivenson et al 1983;Schüller, Gregg, and Reznik 1990;Takahashi, Iwasaki, and Ide 1985;Yamamoto et al 1990;Yu et al 1989) Hyperplasia, Respiratory Epithelium ( …”

“…Squamous metaplasia with normal differentiation pattern is reversible under some experimental circumstances, depending on the nature of inhaled irritant and the duration of exposure, but in other situations it may give rise to squamous papillomas or squamous cell carcinomas. (Boorman, Morgan, and Uraih 1990;Dickhaus et al 1977;Dickhaus et al 1978;Dungworth, Ernst, et al 1992;Dungworth et al 2001;Faccini, Abbott, and Paulus 1990;Gopinath, Prentice, and Lewis 1987;Green et al 1980;Karube et al 1989;Kerns et al 1983;Luts et al 1991;Maekawa and Odashima 1975;Maronpot 1990;Maronpot et al 1986;Pack, Al-Ugaily, and Morris 1981;Pour et al 1976;Rehm and Kelloff 1991;Rehm, Ward, and Sass 1994;Reznik, Schuller, and Stinson 1980;Reznik 1983;Takahashi, Iwasaki, and Ide 1985;Yamamoto et al 1989). …”

“…Squamous metaplasia with a normal maturation pattern may be reversible under some experimental circumstances (e.g., depending on nature of inhaled irritant and duration of exposure) but in other situations may eventually give rise to squamous cell papilloma or squamous cell carcinoma. (Belinsky et al 1987;Boorman, Morgan, and Uraih 1990;Brown 1990;Brown et al 1991;Dungworth, Ernst, et al 1992;Dungworth et al 2001;Feron, Woutersen, and Spit 1986;Gopinath, Prentice, and Lewis 1987;Harkema 1990;Holmström, Wilhelmsson, and Hellquist 1989;Jiang, Buckley, and Morgan 1983;Jiang, Morgan, and Beauchamp 1986;Kerns et al 1983;Maronpot et al 1986;Monticello, Morgan, and Uraih 1990;Quest et al 1984;Renne et al 1986;Reznik, Stinson, and Ward 1980;Reznik-Schüller 1983a;ReznikSchüller 1983b;Rivenson et al 1983;Schüller, Gregg, and Reznik 1990;Takahashi, Iwasaki, and Ide 1985;Turk, Henk, and Flory 1987;Yu et al 1989).…”

“…It develops from hypertrophic epithelium with typical goblet cells distended with secretory droplets. (Belinsky et al 1987;Boorman, Morgan, and Uraih 1990;Brown 1990;Brown et al 1991;Buckley et al 1985;Dungworth, Ernst, et al 1992;Dungworth et al 2001;Feron, Woutersen, and Spit 1986;Gaskell 1990;Gopinath, Prentice, and Lewis 1987;Harkema 1990;Jiang, Morgan, and Beauchamp 1986;Maronpot et al 1986;Monticello, Morgan, and Uraih 1990;Morgan 1991;Quest et al 1984;Renne et al 1986;Reznik, Stinson, and Ward 1980;Reznik, Schuller, and Stinson 1994;Reznik-Schüller 1983a, 1983bRivenson et al 1983;Schüller, Gregg, and Reznik 1990;Takahashi, Iwasaki, and Ide 1985;Yamamoto et al 1990;Yu et al 1989). …”

Effects of exercise exposure on toxic interactions between inhaled oxidant and aldehyde air pollutants

“…While the acute toxic effects of the oxidants, O 3 and NO 2 , occur in lung tissues, HCHO primarily affects epithelial tissues of the upper respiratory tract Buckley et al, 1984;Morgan et al, 1986a,b;Maronpot et al, 1986). This is likely the consequence of relatively high aqueous solubility and preferential deposition of HCHO in the nasal cavity (Egle, 1972;Heck et al, 1983).…”