Toxicity of nanoparticulate and bulk ZnO, Al2O3 and TiO2 to the nematode Caenorhabditis elegans

Wang, Huanhua; Wick, Robert L.; Xing, Baoshan

doi:10.1016/j.envpol.2008.11.004

Cited by 461 publications

(251 citation statements)

References 37 publications

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“…and silica nanoparticles (Wang et al, 2009;Roh et al, 2009;Kim et al, 2008;Pluskota et al, 2009). In general, NPs were shown to reduce nematode lifespan, possibly in response to the particle mediated generation of reactive oxygen species (ROS), and induce a premature degeneration of reproductive organs.…”

Section: Resultsmentioning

confidence: 99%

“…Others have reported that nanomaterials can cause a reduction in nematode reproduction (Wang et al, 2009;Roh et al, 2009;Kim et al, 2008;Pluskota et al, 2009 Table 2). …”

Section: Resultsmentioning

confidence: 99%

“…The harmful effects of ZnONPs are driven by their physicochemical properties (dissolution and formation rate, the morphology and chemical composition, surface reactivity, particle number) and the resulting physical damage caused by the aggregation and agglomeration of nanoparticles (Bai et al, 2010;Jiang et al, 2009;Zhang et al, 2010. The bio-kinetic behaviour and in vivo toxicity of ZnONP exposure has, to date, been investigated in several non-mammalian systems including in vitro cell-based assays (Sharma et al, 2012a,b;Ahamed et al, 2011;Wu et al, 2010), bacteria (Li et al, 2011;Reddy et al, 2007), algae (Franklin et al, 2007), plants (Lin and Xing, 2007), crustaceans (Poynton et al, 2011), fish (Bai et al, 2010), earthworms (Hooper et al, 2011) and nematodes (Khare et al, 2011;Ma et al, 2009;Ma et al, 2011;Roh et al, 2009;Wu et al, 2013). The nematode Caenorhabditis elegans, a powerful model organism due to the availability of a completely sequenced genome (Hillier et al, 2005) and many molecular genetics tools has been used in ecotoxicological research to study the molecular to organismal level responses to ROS and heavy metal challenges (Roh et al, 2006;Hughes and Sturzenbaum 2007;Swain et al, 2004Swain et al, , 2010Zeitoun-Ghandour et al, 2010; The roles of the metalloproteins metallothionein (MT) and phytochelatin (PC) are Furthermore, ZnONP mediated toxicity may result from the release of free ionic zinc (George et al 2010;Li et al, 2012;Poynton et al, 2011;Wang et al, 2009), which induces cellular damage via the generation of free reactive oxygen species (ROS), which in turn can promote pro-inflammatory effects Mocchegiani et al, 2011). assumed to be multi-functional, including metal sequestration, transportation, detoxification, protection against antioxidants …”

Section: Introductionmentioning

confidence: 99%

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Metalloproteins and phytochelatin synthase may confer protection against zinc oxide nanoparticle induced toxicity in Caenorhabditis elegans

Polak

Read

Jurkschat

et al. 2014

Comparative Biochemistry and Physiology Part C: Toxicology &

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Spurgeon, David J.; Sturzenbaum, Stephen R.. 2014. Metalloproteins and phytochelatin synthase may confer protection against zinc oxide nanoparticle induced toxicity in Caenorhabditis elegansContact CEH NORA team at noraceh@ceh.ac.ukThe NERC and CEH trademarks and logos ('the Trademarks') are registered trademarks of NERC in the UK and other countries, and may not be used without the prior written consent of the Trademark owner. suggesting that the nominal exposure to pure ZnONPs represents in vivo, at best, a mixture exposure of ionic zinc and nanoparticles. Nevertheless, the analyzes provided evidence that the metallothioneins (mtl-1 and mtl-2), the pytochelatin synthase (pcs-1) and an apoptotic marker (cep-1) were transcriptionally activated. In addition, the DCFH-DA assay provided in vitro evidence of the oxidative potential of ZnONPs in the metal exposure sensitive triple mutant.Raman spectroscopy highlighted that the biomolecular phenotype changes significantly in the metal sensitive knockout worm upon ZnONP exposure, suggesting that these metalloproteins are instrumental in the protection against cytotoxic damage. Finally, ZnONP exposure was shown to decrease growth and development, reproductive capacity and lifespan, effects which were amplified in the triple knockout. By combining diverse toxicological strategies, we identified that individuals (genotypes) housing mutations in key metalloproteins are more susceptible to ZnONP exposure, which underlines the importance of fully functional metalloproteins to minimize ZnONP induced toxicity.

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Section: Resultsmentioning

confidence: 99%

“…Others have reported that nanomaterials can cause a reduction in nematode reproduction (Wang et al, 2009;Roh et al, 2009;Kim et al, 2008;Pluskota et al, 2009 Table 2). …”

Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Metalloproteins and phytochelatin synthase may confer protection against zinc oxide nanoparticle induced toxicity in Caenorhabditis elegans

Polak

Read

Jurkschat

et al. 2014

Comparative Biochemistry and Physiology Part C: Toxicology &

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“…Using iron NPs, Phenrat et al [40] found that higher concentrations (60 mg/L) resulted in higher aggregation rates and stability of aggregate size in comparison with lower concentrations (2 mg/L). Zinc oxide NPs dispersed in aqueous solution aggregated in a wide range of sizes, resulting in aggregates almost 10-fold larger than the primary NPs [41,42]. Nevertheless, not all particles were incorporated into aggregates, and individual NPs were also detected in suspensions [42,43].…”

Section: Aggregation and Agglomerationmentioning

confidence: 99%

“…Zinc oxide NPs dispersed in aqueous solution aggregated in a wide range of sizes, resulting in aggregates almost 10-fold larger than the primary NPs [41,42]. Nevertheless, not all particles were incorporated into aggregates, and individual NPs were also detected in suspensions [42,43]. Thus, the size distribution of aggregates may vary among particle types.…”

Section: Aggregation and Agglomerationmentioning

confidence: 99%

Metal‐based nanoparticles in soil: Fate, behavior, and effects on soil invertebrates

Tourinho

Gestel²,

Lofts

et al. 2012

Enviro Toxic and Chemistry

401

229

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Abstract-Metal-based nanoparticles (NPs) (e.g., silver, zinc oxide, titanium dioxide, iron oxide) are being widely used in the nanotechnology industry. Because of the release of particles from NP-containing products, it is likely that NPs will enter the soil compartment, especially through land application of sewage sludge derived from wastewater treatment. This review presents an overview of the literature dealing with the fate and effects of metal-based NPs in soil. In the environment, the characteristics of NPs (e.g., size, shape, surface charge) and soil (e.g., pH, ionic strength, organic matter, and clay content) will affect physical and chemical processes, resulting in NP dissolution, agglomeration, and aggregation. The behavior of NPs in soil will control their mobility and their bioavailability to soil organisms. Consequently, exposure characterization in ecotoxicological studies should obtain as much information as possible about dissolution, agglomeration, and aggregation processes. Comparing existing studies is a challenging task, because no standards exist for toxicity tests with NPs. In many cases, the reporting of associated characterization data is sparse, or missing, making it impossible to interpret and explain observed differences in results among studies. Environ. Toxicol. Chem.

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Zinc and Zinc Compounds

Engin

2023

Patty's Toxicology

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Zinc is one of the most abundant elements in the earth's crust and is widely used in the metal, rubber, chemical, paint, and agricultural industry, in addition to the usage in cosmetics ingredients, or for medical purposes. In this context, nano‐sized zinc oxide is used in personal care products, sensors, antibacterial creams, and biomedical applications. In fact, for various organisms, zinc is an essential component in the basic cellular functions. Furthermore, extracellular zinc has the potential to interact with and modulate many different synaptic targets, induce oxidative and nitrosative stress, leading to alteration in the inflammatory responses. It is normally absorbed from the intestine, and competes with Cu 2+ , Fe 2+ , and Ca 2+ for absorption and potentially induces copper deficiency. Consequences of zinc deficiency have been recognized for many years, however high exposure to zinc fumes, zinc compounds, and zinc nanoparticles via inhalation, ingestion, or dermal route may result in severe hematological, developmental, gastrointestinal, and nervous system toxicity. This chapter aims to summarize the knowledge on the regulations of occupational zinc exposure limits and manifestations of bulk and nano‐sized zinc toxicity.

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Toxicity of nanoparticulate and bulk ZnO, Al2O3 and TiO2 to the nematode Caenorhabditis elegans

Cited by 461 publications

References 37 publications

Metalloproteins and phytochelatin synthase may confer protection against zinc oxide nanoparticle induced toxicity in Caenorhabditis elegans

Metalloproteins and phytochelatin synthase may confer protection against zinc oxide nanoparticle induced toxicity in Caenorhabditis elegans

Metal‐based nanoparticles in soil: Fate, behavior, and effects on soil invertebrates

Zinc and Zinc Compounds

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