Toxicity of sodium arsenite in the gill of an economically important mollusc of India

Chakraborty, Sudipta; Ray, Mitali; Ray, Sajal

doi:10.1016/j.fsi.2010.02.025

Cited by 45 publications

(21 citation statements)

References 67 publications

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“…For example, cadmium/copper caused no change in ROS production in mussel (Goméz-Mandikute and Cajaraville 2003). But sodium arsenite could inhibit the activities of CAT and induce oxidative stress in the gills of Lamellidens marginalis (Chakraborty et al 2010). Whatever the antioxidant enzyme activities were up-or down-regulated, the heavy metal contamination exerted adverse effect on some immune parameters of mollusks, and the responding capability depended on the concentration of the metal (Girón-Pérez 2010).…”

Section: Discussionmentioning

confidence: 99%

Effects of heavy metals on the expression of a zinc-inducible metallothionein-III gene and antioxidant enzyme activities in Crassostrea gigas

Cong

Liu

et al. 2012

Ecotoxicology

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Sequestration by metallothioneins and antioxidant defense are two kinds of important defense mechanisms employed by mollusks to minimize adverse effects caused by heavy metal contaminants in marine environment. In the present study, a novel metallothionein gene, CgMT-III, was cloned from Crassostrea gigas, consisting of eighteen conserved cysteine residues and encoding a MT III-like protein with two tandem b domains. The expression level of CgMT-III transcript induced by zinc was much higher than that induced by cadmium exposure. It suggested that CgMT-III was perhaps mainly involved in homeostatic control of zinc metabolism, which was distinct from previously identified MTs in C. gigas. Among the tested antioxidant enzymes including superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), SOD and GPx showed varying up-regulations in a tissuespecific manner, while CAT activities were inhibited in both gill and hepatopancreas from C. gigas exposed to heavy metals. It can be inferred that CgMT-III was mainly involved in zinc homeostasis, and CgMT-III gene together with CAT enzyme could be potential biomarkers to indicate heavy metal, especially zinc pollution in marine organisms.

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Section: Discussionmentioning

confidence: 99%

Effects of heavy metals on the expression of a zinc-inducible metallothionein-III gene and antioxidant enzyme activities in Crassostrea gigas

Cong

Liu

et al. 2012

Ecotoxicology

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“…Similar results were observed for the introduced species exposed to low pH and As, but at pH 7.8, R. philippinarum exposed to As inhibited ALP activity. ALP inhibition was reported in S. plana and in Lamellidens marginalis under metal and As exposure, respectively (Chakraborty et al, 2010;Mazorra et al, 2002) (Table 3) Nevertheless, Moreira et al (2016a) demonstrated no changes in ALP activity in C. gigas exposed to the combined effect of pH (7.8 and 7.3) and As concentrations (0 and 4 mg/L of As) while the oyster C. angulata presented induced ALP activity under As exposure at control pH (7.8) (Table 3). Moreover, the present results indicated that the introduced clam R. philippinarum presented higher ALP activity than native species among all tested conditions.…”

Section: Osmoregulation Capacitymentioning

confidence: 99%

The impacts of As accumulation under different pH levels: Comparing Ruditapes decussatus and Ruditapes philippinarum biochemical performance

Velez

Figueira

Soares

et al. 2016

Environmental Research

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Marine bivalves have been used to assess environmental As contamination and the effects of seawater acidification when both factors are acting alone, but limited information is available regarding the impacts of both factors acting in combination. The aim of this study was to compare physiological (glycogen) and biochemical (lipid peroxidation, superoxide dismutase, catalase, glutathione-S-transferase and alkaline phosphatase) responses in both native (Ruditapes decussatus) and introduced (R. philippinarum) clams, when exposed to the combined effects of pH (7.8, control; 7.3) and As concentrations (0 and 4mg/L). The combined effect of As and pH on the health risks associated with clam consumption was also analyzed. Results revealed that both species were able to accumulate As under both pH levels, although higher As concentrations where observed under low pH. Thus, predicted pH decrease will potentiate health risks associated with the consumption of such species, since less amount of clams exposed to As is needed for an adult to exceed the provisional tolerable weekly intake (PTWI). Low pH, As exposure and the combination of both factors did not negatively affect the native species, since clams were able to maintain their physiological and biochemical performance among all conditions. On the other hand, R. philippinarum was negatively affected by As exposure at control pH (7.8), inducing biotransformation and antioxidant defense mechanisms against As toxicity. R. philippinarum exposed and non-exposed to As presented similar responses under low pH although at this condition the introduced species accumulated twice the amount of As than R. decussatus.

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“…Natural defense against free radicals in biological systems are antioxidants and enzymes with antioxidant properties such as glutathione peroxidase, superoxide dismutase, and catalase. 39,40 Thus, the status of FIG. 5.…”

Section: Figmentioning

confidence: 99%

The Effect of Chronic Arsenic Exposure in Zebrafish

et al. 2016

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Arsenic is a prevalent environmental toxin and a Group one human carcinogenic agent. Chronic arsenic exposure has been associated with many human diseases. The aim of this study is to evaluate zebrafish as an animal model to assess arsenic toxicity in elevated long-term arsenic exposure. With prolonged exposure (6 months) to various concentrations of arsenic from 50 ppb to 300 ppb, effects of arsenic accumulation in zebrafish tissues, and phenotypes were investigated. Results showed that there are no significant changes of arsenic retention in zebrafish tissues, and zebrafish did not exhibit any visible tumor formation under arsenic exposure conditions. However, the zebrafish demonstrate a dysfunction in their neurological system, which is reflected by a reduction of locomotive activity. Moreover, elevated levels of the superoxide dismutase (SOD2) protein were detected in the eye and liver, suggesting increased oxidative stress. In addition, the progenies of arsenic-treated parents displayed a smaller biomass (four-fold reduction in body weight) compared with those from their parental controls. This result indicates that arsenic may induce genetic or epigenetic changes that are then passed on to the next generation. Overall, this study demonstrates that zebrafish is a convenient vertebrate model with advantages in the evaluation of arsenic-associated neurological disorders as well as its influences on the offspring.

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Toxicity of sodium arsenite in the gill of an economically important mollusc of India

Cited by 45 publications

References 67 publications

Effects of heavy metals on the expression of a zinc-inducible metallothionein-III gene and antioxidant enzyme activities in Crassostrea gigas

Effects of heavy metals on the expression of a zinc-inducible metallothionein-III gene and antioxidant enzyme activities in Crassostrea gigas

The impacts of As accumulation under different pH levels: Comparing Ruditapes decussatus and Ruditapes philippinarum biochemical performance

The Effect of Chronic Arsenic Exposure in Zebrafish

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