Toxicokinetics of Atrazine in Embryos of the Zebrafish (Danio rerio)

Wiegand, Claudia; Krause, Eberhard; Steinberg, Christian E. W.; Pflugmacher, Stephan

doi:10.1006/eesa.2001.2073

Cited by 143 publications

(67 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Exposure to two compounds results in albinism: the thiocarbamate insecticide cartap (Zhou et al, 2009) and diethoxy CPO (Jacobson et al, 2010), which is a breakdown product of the organophosphate insecticide, chlorpyrifos (Table 11). Other compounds, such as cadmium (Cheng et al, 2000), atrazine (Wiegand et al, 2001), and ethanol (Hallare et al, 2006), caused a reduced coloration in the embryos, whereas triclosan, an antibacterial and antifungal agent, delayed pigmentation (Table 11). The use of Tg(mitfa:GFP) would allow characterization of more subtle effects on pigmentation.…”

Section: Toxicity On Development Of Skin and Pigmentationmentioning

confidence: 98%

“…Whether ethanol affects DNA methylation in zebrafish has not been studied. Abnormal epiboly was also the effect of exposures to the widely used herbicide, atrazine (Wiegand et al, 2001) and the brominated flame retardant, hexabromocyclododecane (Deng et al, 2009) (Table 4). The persistent organic pollutant PFOS, used as an impregnation agent for textiles, paper, and leather, as a fire-fighting foam, and a protective coating for food packaging, also showed epiboly effects, including the loss of normal cell synchronization during early development (Shi et al, 2008).…”

Section: Early Embryonic Developmental Toxicitymentioning

confidence: 99%

See 1 more Smart Citation

Developmental toxicity screening in zebrafish

McCollum

Ducharme

Bondesson

et al. 2011

Birth Defects Research Part C: Embryo Today: Reviews

140

101

View full text Add to dashboard Cite

Given the ever-increasing toxic exposure ubiquitously present in our environment as well as emerging evidence that these exposures are hazardous to human health, the current rodent-based regulations are proving inadequate. In the process of overhauling risk assessment methodology, a nonrodent test organism, the zebrafish, is emerging as tractable for medium- and high-throughput assessments, which may help to accelerate the restructuring of standards. Zebrafish have high developmental similarity to mammals in most aspects of embryo development, including early embryonic processes, and on cardiovascular, somite, muscular, skeletal, and neuronal systems. Here, we briefly describe the development of these systems and then chronicle the toxic impacts assessed following chemical exposure. We also compare the available data in zebrafish toxicity assays with two databases containing mammalian toxicity data. Finally, we identify gaps in our collective knowledge that are ripe for future studies.

show abstract

Section: Toxicity On Development Of Skin and Pigmentationmentioning

confidence: 98%

Section: Early Embryonic Developmental Toxicitymentioning

confidence: 99%

Developmental toxicity screening in zebrafish

McCollum

Ducharme

Bondesson

et al. 2011

Birth Defects Research Part C: Embryo Today: Reviews

140

101

View full text Add to dashboard Cite

show abstract

“…Up to now, fish have been proven to be useful experimental models for the evaluation of the health of aquatic ecosystems exposed to environmental pollution and the associated biochemical changes [23][24][25][26][27] . It is important to understand that the detoxification mechanism of aquatic species is contaminated with metals, pesticides, herbicides and persistent pollutants 28 .…”

Section: Introductionmentioning

confidence: 99%

Purification of glutathioneS-transferase from Van Lake fish (Chalcalburnus tarichiiPallas) muscle and investigation of some metal ions effect on enzyme activity

Aksoy

Özaslan

Küfrevioğlu

2015

Journal of Enzyme Inhibition and Medicinal Chemistry

View full text Add to dashboard Cite

Glutathione S-transferases (GSTs) are an important enzyme family which play a critical role in detoxification system. In our study, GST was purified from muscle tissue of Chalcalburnus tarichii Pallas with 301.5-fold purification and 19.07% recovery by glutathione agarose affinity chromatography. The purity of enzyme was checked by sodium dodecyl sulfatepolyacrylamide gel electrophoresis, showing a two band, because of having heterodimer structure. K M values were 1.59 and 0.53 mM for 1-chloro-2,4-dinitrobenzene (CDNB) and glutathione (GSH), respectively. V max values for CDNB and GSH were also determined as 5.58 and 1.88 EU/mL, respectively. In addition, inhibition effects of Ag

show abstract

“…The main goals are: firstly, identification of the main route of entry of the www.intechopen. (Wakamatsu et al, 2001;Wiegand et al, 2001;Nagel, 2002;Hill et al, 2005). Other species like rainbow trout (Oncorhynchus mykiss), feathead (Pimephales promeals) and tilapia (Oreochromis niloticus) having large size are more appropriate for the experiments requiring large amounts of tissue, to pursue gene expression profiles, proteomics and lipidomics.…”

Section: Fish As An Economical Vertebrate Model For Toxicity Assementioning

confidence: 99%