Toxicological effects of graphene on mussel Mytilus galloprovincialis hemocytes after individual and combined exposure with triphenyl phosphate

Meng, Xiangjing; Li, Fēi; Wang, Xiaoqing; Liu, Jialin; Ji, Chenglong; Wu, Huifeng

doi:10.1016/j.marpolbul.2019.110838

Cited by 15 publications

(3 citation statements)

References 71 publications

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“…Apoptosis is a modality of cell death, affected by internal and external factors (Renehan et al 2001). Previous studies indicated that apoptosis could be induced by various environmental stressors such as ammonia, heavy metals, persistent organic pollutants (POPs) and pharmaceutical and personal care product (PPCPs) (Guo et al 2017;Meng et al 2020;. For example, a recent study indicated that acute ammonia stress could signi cantly up-regulate the expression of p53 and bax in C.…”

Section: Introductionmentioning

confidence: 99%

“…The mRNA levels of caspase-3 were signi cantly increased in the mussel M. galloprovincialis exposed to graphene and in the white shrimp Litopenaeus vannamei exposed to copper. Combined exposure of graphene and triphenyl phosphate (TPP) signi cantly elevated the transcript levels of NF-κB and bcl-2 in M. galloprovincialis hemocytes (Meng et al 2020). Moreover, triclosan (TCS) could result in apoptosis via the ROS-p53-caspase-dependent apoptotic pathway, inducing the ascent of the mRNA expression level of caspase-3, p53 and bax in zebra sh embryos (Liu et al 2022).…”

Section: Introductionmentioning

confidence: 99%

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A multibiomarker approach to assess the ecotoxicological effects of diclofenac on Asian clam Corbicula fluminea (O. F. Müller, 1774)

Ding

et al. 2023

Environ Sci Pollut Res

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Diclofenac (DCF), one of the most current and widely used nonsteroidal anti-in ammatory drugs (NSAIDs), has been frequently detected in aquatic environments worldwide. However, the ecotoxicological effects of DCF on freshwater invertebrates remain largely unknown. In the present study, Corbicula uminea were exposed to environmentally relevant concentrations of DCF (0, 2, 20 and 200 µg/L) for 28 days, and the potential adverse effects of DCF on siphoning behavior, antioxidant responses and apoptosis were investigated. Our results showed that the siphon e ciencies of clams were signi cantly suppressed by DCF exposure. DCF exerted neurotoxicity via reducing the activity of acetylcholinesterase (AChE) in gills and digestive gland of C. uminea. Exposure to DCF induced antioxidant stress and led to increased malondialdehyde (MDA) levels in both tissues of C. uminea. Transcriptional alterations of apoptosis-related genes indicated that DCF might induce apoptosis by triggering mitochondrial apoptotic pathway. Our ndings will help enhance our awareness of the negative effects of DCF on freshwater bivalves and highlight the ecological risks of DCF in freshwater ecosystems.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

A multibiomarker approach to assess the ecotoxicological effects of diclofenac on Asian clam Corbicula fluminea (O. F. Müller, 1774)

Ding

et al. 2023

Environ Sci Pollut Res

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“…Mussel Mytilus galloprovincialis exhibits strong bioaccumulation of environmental pollutants (Ji et al, 2016;Wu et al, 2018;Meng et al, 2020). Because of its high capacity, pollutant tolerance, easy collection, and wide distribution, M. galloprovincialis serves as an excellent specimen for monitoring the marine environment (Ji et al, 2014;Yu et al, 2016;Meng et al, 2019).…”

Section: Introductionmentioning

confidence: 99%

Dose-Dependent Effects of Di-(2-Ethylhexyl) Phthalate (DEHP) in Mussel Mytilus galloprovincialis

Cao

Sun

et al. 2021

Front. Mar. Sci.

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Phthalic acid esters (PAEs) are environmental organic pollutants that are ubiquitous in the ocean, and di-(2-ethylhexyl) phthalate (DEHP) is the most widely used PAE. The environmental concentration of DEHP was reported to be up to 42.52 μg/L in seawater in the estuaries located in Jiaozhou Bay along the Yellow Sea. DEHP has been investigated with respect to its toxicity in marine organisms. However, evidence on the dose-dependent effects of DEHP remains contradictory and limited. We used marine mussel Mytilus galloprovincialis as the experimental animal to study the dose-dependent effects of various levels of exposure to DEHP (concentrations of 4, 12, 36, 108, and 324 μg/L). These effects and the underlying mechanisms were elucidated by the levels of antioxidant enzyme activity, gene expression, and metabolite. The results indicated that, at environmentally relevant concentrations (12 and 36 μg/L), DEHP induced significant hormetic effects. This was indicated by the U-shaped or inverted U-shaped responses of the gene expression levels related to stress response (CAT, GST, and MgGLYZ) and antioxidant enzyme activities (SOD and CAT). The metabolic profiles revealed that DEHP generally caused monophasic response in osmotic regulation (homarine) and biphasic response (hormesis) in energy metabolism (glucose, glycogen, and amino acids), respectively. These findings can aid in ecological risk assessment with respect to DEHP and the determination of hormetic dose responses.

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Toward the Application of Graphene for Combating Marine Biofouling

Jin

Tian

Bing

et al. 2020

Advanced Sustainable Systems

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The discovery of graphene has brought great innovations to materials science. Since tributyltin antifouling coatings were banned worldwide in 2008, the development of green antifouling coatings has become necessary. Recently, novel graphene‐related antifouling coatings have been the focus of many studies due to their enhanced mechanical strength, excellent antifouling capabilities, and environmental friendliness. This review starts by introducing the basic antifouling mechanisms of graphene nanosheets and the possible antifouling mechanisms when graphene is incorporated into coatings. Subsequently, the progress and existing problems regarding the application of graphene in the prevention of marine biofouling are discussed. Specifically, this review focuses on six graphene‐related antifouling coatings, including pure graphene film, nanohybrids, foul release coatings, photocatalytic nanocomposites, desalination membranes, and materials for uranium enrichment. The fabrication, antifouling properties, working mechanisms, and future development of graphene‐related antifouling coatings are highlighted. In addition, the potential environmental risk of using graphene materials in preventing marine biofouling is explained, and the basic requirements for designing an environmentally friendly graphene‐related antifouling coating are discussed. Finally, the prospect of applying graphene materials for combating marine biofouling is presented. This review aims to aid in improving the design of graphene‐related green antifouling coatings.

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Toxicological effects of graphene on mussel Mytilus galloprovincialis hemocytes after individual and combined exposure with triphenyl phosphate

Cited by 15 publications

References 71 publications

A multibiomarker approach to assess the ecotoxicological effects of diclofenac on Asian clam Corbicula fluminea (O. F. Müller, 1774)

A multibiomarker approach to assess the ecotoxicological effects of diclofenac on Asian clam Corbicula fluminea (O. F. Müller, 1774)

Dose-Dependent Effects of Di-(2-Ethylhexyl) Phthalate (DEHP) in Mussel Mytilus galloprovincialis

Toward the Application of Graphene for Combating Marine Biofouling

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