Toxicological evaluation of aqueous extract of different varieties of guava (Psidium guajava Linn) leaves

Babatola, Leye Jonathan; Oboh, Ganiyu; Ademiluyi, Adedayo O.

doi:10.1007/s00580-019-03002-0

Cited by 10 publications

(10 citation statements)

References 15 publications

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“…The following micrographic plates are the results of histological processing of testicular tissue samples: The outcome of the assessment of acute oral toxicity, which meant to find out the amount of P. guajava leaf that can kill half (50%) of the animals in a group of the test population, showed that the median lethal dose (LD50) level of the aqueous extract is over 5000 mg/kg, as there was no record of mortality, fatality or lethality even when the rats dosed up to that amount. This finding is in alignment with a previous report of a toxicological evaluation of aqueous extract of different varieties of guava leaves in rats, which indicated that there were no deaths recorded during the study and that the NOAEL (no observed adverse effect level) estimate of white, red and pink guava leaves extract is 50 -5000 mg/kg 26 .…”

Section: Histomorphological Findingssupporting

confidence: 91%

Morphological Alterations of the Rat Testicles Following Administration of Graded Doses of Leaves of Guava (Psidium guajava Linn.) Aqueous Extract

Etim¹,

Isaac²,

Igiri³

2021

Trop. H. Med. Res.

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The current study design to assess the dose-response effect of administering an aqueous extract of guava leaves on the microstructure of the testicles due to the growing use of this plant in complementary and alternative medicine practice. Twenty-four male albino Wistar rats with an average body weight of 160 g apportion to four groups (n=6 each). Group, I served as the control and received distilled water; group II gave a lower dose of 500 mg/kg body weight of guava leaf extract; group III received a medium dose of 750 mg/kg; while group IV administer a higher amount of 1000 mg/kg per day. Treatments were given once daily by gavage and lasted for 14 days, while the stock solution prepares by dissolving 50 g of the extract in 30 ml of water. The cervical dislocation method used to euthanize the rats, dissect the abdominopelvic region to obtain tissue specimens from the testes for histological processing. The outcome exhibited the extract to cause moderate to severe (dose-dependent) morphological alterations with the seminiferous tubules' fibrotic appearance, strict spermatogenic arrest, and necrosis of both the interstitial cells of Leydig and the Sertoli cells. The ingestion of guava leaves at the investigated concentration and doses is harmful to the testicle, the primary reproductive organ in males. It should therefore be consumed with caution when being used primarily in folklore-traditional medicine.

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Section: Histomorphological Findingssupporting

confidence: 91%

Morphological Alterations of the Rat Testicles Following Administration of Graded Doses of Leaves of Guava (Psidium guajava Linn.) Aqueous Extract

Etim¹,

Isaac²,

Igiri³

2021

Trop. H. Med. Res.

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“…These results suggest that the essential oils of the leaves of Psidium guajava and Ocimum gratissimum, can be potentially toxic. Indeed, a significant weight loss of more than 10% is a sign of toxic effects caused by the intake of a substance [12,13] . It could be explained by the presence in these essential oils of antinutritional compounds responsible for a decrease in food intake of treated rats [14] .…”

Section: Discussionmentioning

confidence: 99%

Comparative study of acute oral toxicity of essential oils of Ocimum gratissimum, Hyptis suaveolens and Psidium guajava in wistar rats

Degla¹,

Olounladé²,

Attindehou³

et al. 2021

Int. J. Pharmacognosy Life Sci.

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The essential oils from Ocimum gratissimum, Hyptis suaveolens (Lamiceae) and Psidium guajava (Myrtaceae) have biological properties. The aim of this work is to compare the effect of essential oils of these three medicinal plants on weight growth, hematological and biochemical parameters of treated rats through the procedure of acute toxicity evaluation on Wistar rats. The doses applied are 100, 250 and 500mg/Kg bw for each of the essential oils From the results obtained, the effects of essential oils of Ocimum gratissimum, Hyptis suaveolens and Psidium guajava leaves on biochemical, hematological parameters and weight growth of rats are dose dependent. At the dose of 500mg/Kg bw, they significantly increased the rate of white blood cells, urea, creatinemia, transaminases and reduced the weight growth of rats by more than 10% (p<0.05) compared to the control lot. This shows that these essential oils can have toxic effects when applied in high doses.

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“…e administration of the Psidium guajava fruit extract [54], as well its leaves extract [53], was safe and not toxic to the liver and kidney. Only the repeat administration of Psidium guajava bark extract could exhibit mild organ toxicity [55].…”

Section: Veterinary Medicine Internationalmentioning

confidence: 92%

“…e healthy indicator of the liver is serum aspartate aminotransferase, alkaline phosphate, alanine aminotransferase, and bilirubin. Meanwhile, the renal marker is creatinine, urea, uric acid, and blood urea nitrogen [53].…”

Section: Veterinary Medicine Internationalmentioning

confidence: 99%

The Restorative Effect of Red Guava (Psidium guajava L.) Fruit Extract on Pulmonary Tissue of Rats (Rattus norvegicus) Exposed to Cigarette Smoke

Meles

Mustofa

Wurlina

et al. 2021

Veterinary Medicine International

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Since the damage to alveolar tissue due to cigarette smoke exposure (CSE) is lipid peroxidation, antioxidant treatment is needed. The red guava (Psidium guajava L.) fruit contains antioxidants derived from quercetin, lycopene, and vitamin C. This study aimed to determine the effect of red guava fruit extract (RGFE) on the alveolar tissue of rats exposed to cigarette smoke. The 25 rats (Rattus norvegicus) were divided into five groups. The control and T0 groups were only administered placebo, while T1, T2, and T3 groups were orally administered RGFE of 18.9, 37.8, and 56.7 mg/kg body weight daily for 44 days. The CSE dose of 20 suctions daily was conducted on T0, T1, T2, and T3 groups on days 15–44. On day 45, all rats were sacrificed for serum collection and histopathological lung slides with eosin-nigrosin staining. The result showed that CSE caused an increase p < 0.05 in malondialdehyde (MDA) levels, cell death, apoptosis, and necrosis percentages, congestion and thickening of alveolar septum tissue, and reduction in the alveolar diameter and alveolar number. Administration of RGFE suppressed those effects, and the highest dose of RGFE (T3) restored p > 0.05 MDA levels, percentage of apoptotic and necrosis, alveolar septal thickening, and alveolar diameter. However, the percentages of cell death, alveolar congestion, and the alveolar number were still worse p < 0.05 than in normal rats. It could be concluded that RGFE has proved relief and restoration of the alveolar tissue of rats exposed to cigarette smoke.

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Toxicological evaluation of aqueous extract of different varieties of guava (Psidium guajava Linn) leaves

Cited by 10 publications

References 15 publications

Morphological Alterations of the Rat Testicles Following Administration of Graded Doses of Leaves of Guava (Psidium guajava Linn.) Aqueous Extract

Morphological Alterations of the Rat Testicles Following Administration of Graded Doses of Leaves of Guava (Psidium guajava Linn.) Aqueous Extract

Comparative study of acute oral toxicity of essential oils of Ocimum gratissimum, Hyptis suaveolens and Psidium guajava in wistar rats

The Restorative Effect of Red Guava (Psidium guajava L.) Fruit Extract on Pulmonary Tissue of Rats (Rattus norvegicus) Exposed to Cigarette Smoke

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