Toxicological Studies of “Chondrokola rosh”, an Ayurvedic Preparation on Liver Function Tests of Rats

Nasrin, Shamima; Bachar, Sitesh C.; Choudhuri, M. S. K.

doi:10.4314/ajtcam.v8i5s.22

Cited by 6 publications

(5 citation statements)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Injury to the structural integrity of the liver is seen by an elevated serum transaminase as the cytoplasms are found and discharged into circulation after cellular damage (Pari & Kumar, 2002 ). Enhancement of bilirubin indicates abnormal liver function, resulting from the higher synthetic function of the liver (Nasrin et al., 2011 ). In this study, Table 4 shows a significant ( p < .001) rise in the bilirubin level of diabetic animals compared with normal control animals.…”

Section: Discussionmentioning

confidence: 99%

Ganoderma applanatum mushroom provides new insights into the management of diabetes mellitus, hyperlipidemia, and hepatic degeneration: A comprehensive analysis

Hossain

Barua

Tanim

et al. 2021

Food Science & Nutrition

View full text Add to dashboard Cite

Diabetes mellitus is a metabolic disorder characterized by a relative or total insulin deficit and hyperglycemia (Karunasagara et al., 2020). Diabetic patients suffer from numerous disorders, including vascular illness, like atherosclerosis, neuropathic pain, and diabetes neuropathy (Papatheodorou et al., 2018). According to the report of 2019, 463 million individuals between the ages of 20 and 79 are estimated to have diabetes globally (Saeedi et al., 2019). By 2045, the number of affected people with diabetes is expected to increase to 700 million worldwide. Bangladesh has been in the top ten positions in the world for the number of adults (20-79 years) with diabetes (8.4 million) in 2019. The prevalence of diabetes will be increased to 15.0 million by 2045. Bangladesh has also been ranked nine in 2019 among the countries for 4.7 million adults with undiagnosed diabetes (Atlas, 2015;

show abstract

Section: Discussionmentioning

confidence: 99%

Ganoderma applanatum mushroom provides new insights into the management of diabetes mellitus, hyperlipidemia, and hepatic degeneration: A comprehensive analysis

Hossain

Barua

Tanim

et al. 2021

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

“…(2011) [34] reported chondrokola rosh from H. indicus roots, which helps in dysuria. Periyanayaga et al (2004) [35] reported pinda thailam from H. indicus roots with anti-inflammatory properties.…”

Section: Value Added Productsmentioning

confidence: 99%

Nutritional, pharmacological activities and food application of nannari root: A review

Faaiz

2023

Pharma Innovation

View full text Add to dashboard Cite

Hemidesmus indicus, commonly known as Indian Sarsaparilla and locally known as nannari is a medicinal plant that has been used in traditional Ayurvedic medicine for centuries. This plant is known for its diverse phytochemical composition, including flavonoids, saponins, alkaloids, and phenolic compounds, which have been found to possess potent antioxidant and anti-inflammatory properties. The antioxidant activity of Hemidesmus indicus has been linked to its ability to scavenge free radicals and inhibit oxidative stress, which can contribute to the development of chronic diseases such as cancer, diabetes, and cardiovascular diseases. Hemidesmus indicus has been shown to have several health benefits, including anti-cancer, anti-diabetic, anti-inflammatory, and anti-microbial properties. The plant has also been found to have wound healing, neuroprotective, and hepatoprotective effects. Due to its health-promoting properties, Hemidesmus indicus has attracted significant attention in the food and pharmaceutical industries. Value-added products such as health supplements, functional foods, and herbal medicines have been developed from Hemidesmus indicus to cater to the growing demand for natural and safe alternatives to conventional medicines. In conclusion, Hemidesmus indicus is a promising plant with diverse phytochemicals that possess potent antioxidant and health-promoting properties. Further research is needed to fully understand the mechanisms behind its medicinal properties and to explore its potential as a source of natural antioxidants and functional ingredients for the food and pharmaceutical industries.

show abstract

“…Sericite is highly refractive and is found in hydrothermally altered rocks [ 6 ]. Traditionally, sericite has been used to alleviate pain in the reproductive organs and to treat bleeding, dysentery, gastric diseases, and inflammation [ 7 ]. It has been shown previously that mica demonstrates chemopreventive potential against colorectal cancers by blocking the cell cycle and proliferation [ 8 ].…”

Section: Introductionmentioning

confidence: 99%

Antitumor Potential of Sericite Treatment Mediated by Cell Cycle Arrest in Triple-Negative MDA-MB231 Breast Cancer Cells

Kim

Nagar

Lee

et al. 2022

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Breast cancer is the most common cancer and the leading cause of cancer-related mortality among females worldwide. Triple-negative breast cancer (TNBC) accounts for about 10–15% of all breast cancers and is usually more aggressive and has a poorer prognosis. Sericite has been known to have antitumor and immune-stimulatory effects. Although the chemopreventive potential of sericite has been demonstrated in other cancers, its molecular pathways in TNBC still require investigation. Thus, in the present study, the antitumor mechanism of sericite against MDA-MB231 breast cancer cells was examined in vitro and in an in vivo xenograft mouse model. Sericite treatment reduced cell proliferation and cell proliferation marker proliferating cell nuclear antigen (PCNA) in MDA-MB231 cells. It also decreased the total cell number and arrested cells in the G0/G1 phase of the cell cycle with an increase in the phosphorylation of P53 and upregulation of cell cycle regulatory proteins P21 and P16. In addition, sericite treatment also induced apoptosis signaling, which was evident by the upregulation of apoptotic protein markers cleaved caspases 3 and 9. A reduction in reactive oxygen species (ROS), NADPH oxidase 4 (NOX4), p22phox, and heat shock proteins (HSPs) was also observed. Similar results were obtained in vivo with significantly reduced tumor volume in sericite-administered mice. Collectively, these findings suggest that sericite has antitumor potential based on its property to induce cell cycle arrest and apoptotic cell death and therefore could serve as a potential therapeutic agent and crucial candidate in anticancer drug development for TNBC.

show abstract

Toxicological Studies of “Chondrokola rosh”, an Ayurvedic Preparation on Liver Function Tests of Rats

Cited by 6 publications

References 11 publications

Ganoderma applanatum mushroom provides new insights into the management of diabetes mellitus, hyperlipidemia, and hepatic degeneration: A comprehensive analysis

Ganoderma applanatum mushroom provides new insights into the management of diabetes mellitus, hyperlipidemia, and hepatic degeneration: A comprehensive analysis

Nutritional, pharmacological activities and food application of nannari root: A review

Antitumor Potential of Sericite Treatment Mediated by Cell Cycle Arrest in Triple-Negative MDA-MB231 Breast Cancer Cells

Contact Info

Product

Resources

About