Toxins other than aflatoxins produced by Aspergillus flavus.

Wilson, B J

doi:10.1128/mmbr.30.2.478-484.1966

Cited by 29 publications

(10 citation statements)

References 10 publications

(11 reference statements)

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“…For extraction and detection of aflatoxins, experimental techniques used by authors supplying the cultures were rigorously followed. Some of the isolates were sources of other interesting toxins as first noted by animal feedings (13)(14)(15).…”

Section: Methodsmentioning

confidence: 94%

“…The first of these latter reports (5) has been cited frequently in subsequent literature. Biochemical relationships among diverse species of microorganisms, as evidenced by formation of common toxic metabolites, are well known (13). Therefore, there was little reason initially to question the finding of additional fungal sources of aflatoxins, although such information is of considerable significance.…”

mentioning

confidence: 99%

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Investigation of Reported Aflatoxin Production by Fungi Outside the Aspergillus flavus Group

Wilson¹,

Campbell²,

Hayes³

et al. 1968

Applied Microbiology

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A screening study of 121 fungus isolates, representing 29 species, for aflatoxin synthesis demonstrated this property only in Aspergillus flavus and A. parasiticus. Eight of the organisms found negative were isolates reported by other investigators to produce aflatoxin. Since similar negative reports have come from several other workers, it is concluded that only the A. flavus group of Aspergillus can presently be certified as sources of these toxins. Reasons for possible false-positive findings are discussed along with precautionary measures and differential analytical procedures useful in aflatoxin screening studies.

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Section: Methodsmentioning

confidence: 94%

mentioning

confidence: 99%

Investigation of Reported Aflatoxin Production by Fungi Outside the Aspergillus flavus Group

Wilson¹,

Campbell²,

Hayes³

et al. 1968

Applied Microbiology

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“…In Takadiastase, a commercial crude enzyme preparation from an Aspergillus species, two distinct (extracellular) ribonculeases have been found (171). Lastly, lower fungi produce many toxins, including the well-known aflatoxin (118,225); their possible relation to sporulation apparently has not been looked into.…”

Section: Cytological Classification Of the Mutantsmentioning

confidence: 99%

Sporulation and the production of antibiotics, exoenzymes, and exotonins.

Schaeffer¹

1969

Bacteriological Reviews

213

137

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“…Bei den Organen der Tiere, die das verpilzte Geflugelfutter oral aufgenommen hatten, war ebenfalls kein Befund zu erheben, abgesehen der herdformigen Verfettung von Epithelien einzelner Tubuli contorti in einer N iere. gebildeten tremorgenen Substanzen (4,14,25,33,34,35,36 u. a.).…”

Section: Resultate Der Durchflhrung Biologischer Verfahrenunclassified

Nachweis von Aflatoxinen in Gegenwart von interferierenden Substanzen

Kahlau

Gedek

2010

Zentralblatt Für Veterinärmedizin Reihe B

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Zusammenfassung Es wird über Versuche berichtet, Aflatoxin B1‐vortäuschende Stoffe, die bei der Anwendung der Extraktionsmethode nach Pons et al. (1966) bei anschließender dünnschichtchromatographischer Auftrennung den Aflatoxin B1‐Nachweis stören können, auf physikalisch‐chemischem Wege zu eliminieren. Dabei wurde auch versucht, die Aussagekraft der DC‐Verfahren durch die zusätzliche Anwendung biologischer Tests zu erhöhen. Es gelang, die Interferenz des Antioxydans Ethoxyquin mit Aflatoxin B1 dünnschichtchromatographisch durch die Wahl geeigneter Fließmittelsysteme (insbesondere von Toluol‐Äthylacetat‐90%ige Ameisensäure, 5:4:1) auszuschalten, jedoch nicht bei Verwendung des säulenchromatographischen Verfahrens, wie es von Ranfft (1974) beschrieben worden ist. Desweiteren wurde nachgewiesen, daß Ethoxyquin die Erpebnisse biologischer Verfahren auf Grund eventueller Toxizitat unbeeinflußt läßt. Im Falle eines Aflatoxins B1‐vortäuschenden neuen Stoffwechselproduktes von Aspergillus flavus Link war die Eliminierung der Interferenz nur mit Hilfe zusätzlicher biologischer Tests möglich. Dabei führte jedoch erst die vergleichende Anwendung von mehreren Methoden zu einem diagnostisch verwertbaren Ergebnis. Summary Detection of aflatoxins in the presence of interfering substances 2. Studies on elimination of substances that interfere with thin layer chromatography determination of aflatoxin B1 Studies are reported on elimination by physico‐chemical methods of substances that interfere with the thin layer chromatographic determination of aflatoxin B1. Attempts were also made to improve the value of the chromatographic methods by using supplementary biological tests. It proved possible to exclude the interference caused by the antioxidant Ethoxyquin by choosing a suitable elution system (especially toluol‐ethyl acetate‐90% formic acid, 5:4:1). The same could not be achieved with column chromatography as described by Ranfft (1974). It was also shown that Ethoxyquin is not affected by the use of biological techniques because of its toxicity. In the case of interference caused by a new metabolic product of Aspergillus ffavus Link this can only be effected by using supplementary biological tests. Only the use of several methods of determination of aflatoxins can provide satisfactory diagnostic results. Résumé Mise en évidence d'aflatoxines en présence de substances interférentes Communication II: Essai d'élimination des substances s'interférand avec l'aflatoxine B1 en chromatographie sur couche mince On rapporte les essais d'élimination de substances s'interférant avec l'aflatoxine B1 par un procédé physico‐chimique lors de la séparation finale en chromatographie sur couche mince selon la méthode d'extraction de Pons et al. (1966). On a recherché conjointement á augmenter l'efficacité du procédé de la chromatographie sur couche mince par l'emploi de tests biologiques supplémentaires. On a réussi á éliminer l'interférence de l'antioxydant éthoxyquine avec I'aflatoxine B1 en chromatographie sur couche mince par le choix d'un s...

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Toxins other than aflatoxins produced by Aspergillus flavus.

Cited by 29 publications

References 10 publications

Investigation of Reported Aflatoxin Production by Fungi Outside the Aspergillus flavus Group

Investigation of Reported Aflatoxin Production by Fungi Outside the Aspergillus flavus Group

Sporulation and the production of antibiotics, exoenzymes, and exotonins.

Nachweis von Aflatoxinen in Gegenwart von interferierenden Substanzen

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