Trace Elements in the Hair of Hemodialysis Patients

Ochi, Akinobu; Ishimura, Eiji; Tsujimoto, Yoshihiro; Kakiya, Ryusuke; Tabata, Tsutomu; Mori, Katsuhito; Shoji, Tetsuo; Yasuda, Hiroshi; Nishizawà, Yoshiki; Inaba, Masaaki

doi:10.1007/s12011-010-8948-y

Cited by 32 publications

(26 citation statements)

References 31 publications

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“…However, the study concerning the levels of different elements in hair of haemodialysis patients revealed that the statistically significant increase in iron was accompanied with a slight decrease in lithium [44]. In the present study, serum iron as well as mean corpuscular haemoglobin was slightly decreased in the lithium-treated group, and selenium co-administration seemed to exert a slight beneficial effect.…”

Section: Discussioncontrasting

confidence: 45%

Could Selenium Administration Alleviate the Disturbances of Blood Parameters Caused by Lithium Administration in Rats?

Kiełczykowska

Kocot

Kurzepa

et al. 2014

Biol Trace Elem Res

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Lithium is widely used in medicine, but its administration can cause numerous side effects. The present study aimed at the evaluation of the possible application of selenium, an essential and antioxidant element, as a protective agent against lithium toxicity. The experiment was performed on four groups of Wistar rats: I (control)—treated with saline, II (Li)—treated with lithium (Li2CO3), III (Se)—treated with selenium (Na2SeO3) and IV (Li + Se)—treated with lithium and selenium (Li2CO3 and Na2SeO3) in the form of water solutions by stomach tube for 6 weeks. The following biochemical parameters were measured: concentrations of sodium, potassium, calcium, magnesium, phosphorus, iron, urea, creatinine, cholesterol, glucose, total protein and albumin and activities of alkaline phosphatase, aspartate aminotransferase and alanine aminotransferase in serum as well as whole blood superoxide dismutase and glutathione peroxidase. Morphological parameters such as red blood cells, haemoglobin, haematocrit, mean corpuscular volume, mean corpuscular haemoglobin, mean corpuscular haemoglobin concentration, platelets, white blood cells, neutrophils as well as lymphocytes were determined. Lithium significantly increased serum calcium and glucose (2.65 ± 0.17 vs. 2.43 ± 0.11; 162 ± 31 vs. 121 ± 14, respectively), whereas magnesium and albumin were decreased (1.05 ± 0.08 vs. 1.21 ± 0.15; 3.85. ± 0.12 vs. 4.02 ± 0.08, respectively). Selenium given with lithium restored these parameters to values similar to those observed in the control (Ca—2.49 ± 0.08, glucose—113 ± 26, Mg—1.28 ± 0.09, albumin—4.07 ± 0.11). Se alone or co-administered with Li significantly increased aspartate aminotransferase and glutathione peroxidase. The obtained outcomes let us suggest that the continuation of research on the application of selenium as an adjuvant in lithium therapy seems warranted.

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Section: Discussioncontrasting

confidence: 45%

Could Selenium Administration Alleviate the Disturbances of Blood Parameters Caused by Lithium Administration in Rats?

Kiełczykowska

Kocot

Kurzepa

et al. 2014

Biol Trace Elem Res

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“…D Van Renterghem et al, had demonstrated elevated concentrations of cadmium in the sera of five patients who were on haemodiafiltration [31]. Bing Chen et al, who studied the whole blood and serum samples of stable Chinese chronic renal failure patients (n=81), haemodialysis patients (n=135), posttransplant patients (n=60) and subjects with normal renal functions (n=42), found a high prevalence of elevated cadmium levels in the haemodialysis patients [33].…”

Section: Resultsmentioning

confidence: 99%

“…In addition, higher arsenic concentrations were found in the serum and the packed cells of patients who had a greater degree of chronic renal insufficiency [30]. A recent study demonstrated that the arsenic level in hair was significantly higher in the haemodialysis patients, as compared to that in healthy subjects [31].…”

Section: Resultsmentioning

confidence: 99%

Blood Arsenic and Cadmium Concentrations in End-Stage Renal Disease Patients who were on Maintenance Haemodialysis

Palaneeswari

Pm²,

Silambanan³

et al. 2013

JCDR

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Background: In India, there is a rising burden of chronic diseases like hypertension and diabetes. It has been estimated that 25-40% of these patients are likely to develop chronic kidney disease (CKD), with a significant percentage requiring renal replacement therapy. Haemodialysis is the most common method which is used to treat advanced and permanent kidney failure. Derangements in the metabolism of several toxic and trace elements such as antimony, arsenic cadmium, molybdenum, nickel, and selenium have been reported for several decades in patients with chronically reduced renal functions. Overall, the available literature suggests that the blood levels of some elements such as cadmium, chromium, fluorine, iodine, lead, or vanadium are high in end-stage renal disease (ESRD). Aim and Objectives:Our aim was to study the levels of blood arsenic and cadmium in ESRD patients who were on maintenance haemodialysis (MHD), and to study whether there was any relationship between their concentrations and the duration of the MHD. Methods:The blood lead levels were determined in 50 healthy subjects with normal renal functions and in 50 patients with ESRD, who were on MHD. None of them had any history of smoking or any industrial exposure. Results:The results of the study revealed that the blood arsenic and cadmium concentrations were higher in the ESRD patients who were on MHD than in the healthy adults. The blood arsenic and cadmium concentrations were found to increase with the duration of the MHD. Conclusion:The mild increase in the blood arsenic and cadmium concentrations, with an increase in the duration of the MHD in the study population, may be viewed in the wider context, that a prolonged exposure to arsenic and cadmium, even at low levels, may result in renal damage and/or progression of an already existing CKD.

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“…10,15) Furthermore, renal disorders and hypertension, which are most common complications associated with diabetes, affect the levels of elements in the hair of diabetic subjects. [14][15][16]29) Detail studies focused on age and gender, in addition to the renal disorders and hypertension, are necessary to elucidate fully the changes in the concentrations of element in the scalp hair.…”

Section: Discussionmentioning

confidence: 99%

“…However, some data for Mn and Mg previously reported in relation to diabetic subjects were controversial, 1) and nephropathy and hypertension, which are common complications of diabetes, affect the level of trace elements in the scalp hair. 8,[14][15][16] There is no report on the correlation between HbA1c and the concentrations of essential and toxic metals in the scalp hair so far. In the present study, we investigate the relationships between HbA1c and the concentrations of 12 elements (Ca, Mg, Zn, Cu, Fe, Cr, Mn, V, As, Cd, Hg and Pb) in the scalp hair and between HbA1c and eGFR of diabetic patients in Japan.…”

mentioning

confidence: 99%

Essential and Non-essential Elements in Scalp Hair of Diabetics: Correlations with Glycated Hemoglobin (HbA1c)

Hotta

Fujino

Kimura

et al. 2018

Biological & Pharmaceutical Bulletin

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Essential elements (Ca, Mg, Zn, Cu, Fe, Cr, Mn and V) and non-essential elements (As, Cd, Hg and Pb) were measured in scalp hair samples of 45 diabetic subjects and 59 control subjects in Japan using inductively coupled plasma mass spectrometry. All diabetic subjects took insulin and/or antidiabetic agents, with glycated hemoglobin (HbA1c) ranging between 6.2 and 14.4%. The levels of Zn, Cu and Cr in the diabetic subjects (HbA1c>7) were significantly lower than those in the control subjects (p<0.05), and these concentrations decreased significantly with increases in HbA1c (p<0.01). The levels of Fe and Mg in the diabetic subjects were insignificantly lower, and the concentration of Fe decreased significantly with increases in HbA1c (p<0.05) and the concentration of Mn tended to decrease (p<0.10). In contrast, the concentration of As tended to increase with increases in HbA1c ( p<0.10). The concentrations of other elements, such as Ca, Mn, V, Pb, Cd and Hg, in the diabetic subjects were similar to those of control subjects, and did not correlate with HbA1c. The average of estimated glomerular filtration rate (eGFR) in the diabetic subjects was 77.7 29.7 mL/min/1.73 m 2 with large variation (12.7-148 mL/min/1.73 m 2 ), and previous study reported the increase of urinary excretion of Zn, Cr, Mn and Mg in diabetic subjects. The decreases of Zn, Cu, Cr, Fe and Mg concentrations in hair may reflect increased urinary excretion of these elements due to diabetic nephropathy.Key words diabetes; scalp hair; glycated hemoglobin (HbA1c); zinc; chromium; copper Diabetes mellitus is a serious and chronic metabolic disorder. Type 2 diabetes results from a disruption in glucose metabolism associated with a reduction in insulin production and utilization by tissues. Glycated hemoglobin (HbA1c) levels are used for screening and diagnostic purposes as HbA1c indicates the quality of blood glucose control over the previous 1-2 or 2-3 months. A HbA1c (%) value greater than 6.5 is a cut-off point for diabetic subjects and is highly prognostic for longterm diabetes-related complications such as nephropathy, retinopathy and neuropathy, and maintenance of the HbA1c value below 7.0 is a therapeutic guideline for the prevention of such complications of the Japan Diabetic Society. Estimated glomerular filtration rate (eGFR) is used for screening for nephropathy. The glomerular filtration rate (GFR) generally decreases as diabetes progresses, but the early stage of diabetic nephropathy is characterized by hyperfiltration (increase of GFR). 1) Deficiencies in trace elements such as Cr, Zn, Cu, Mg and Mn have been shown to predispose a person to glucose tolerance and to promote the development of diabetic complications. 2,3) Insulin resistance (IR) is defined as the condition in which insulin sensitive tissues become numb to insulin reception, and a Cr deficiency can induce IR. 2) Zn is known to synthesize insulin as well as stabilize insulin that has been stored in the beta cells of the pancreas. 4) Further, Zn has an important role in the sec...

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Trace Elements in the Hair of Hemodialysis Patients

Cited by 32 publications

References 31 publications

Could Selenium Administration Alleviate the Disturbances of Blood Parameters Caused by Lithium Administration in Rats?

Could Selenium Administration Alleviate the Disturbances of Blood Parameters Caused by Lithium Administration in Rats?

Blood Arsenic and Cadmium Concentrations in End-Stage Renal Disease Patients who were on Maintenance Haemodialysis

Essential and Non-essential Elements in Scalp Hair of Diabetics: Correlations with Glycated Hemoglobin (HbA1c)

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