Tranexamic Acid in Melasma: A Review

Poojary, Shital; Minni, Khushboo

doi:10.4172/2376-0427.1000228

Cited by 22 publications

(66 citation statements)

References 20 publications

(20 reference statements)

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“…Topical TA is postulated to inhibit plasminogen from binding to keratinocytes by various mechanisms. It is thought to interfere with the lysin binding sites on keratinocytes which in turn downregulates prostaglandin, a stimulator of tyrosinase, resulting in a decline in tyrosinase activity and melanogenesis (Li, Shi, Li, Liu, & Feng, 2010;Poojary & Minni, 2015). TA is also found to block the Sc-uPA pathway and affect the plasminogen plasmin system, which eventually reduces hyperpigmentation (Maeda & Tomita, 2007).…”

Section: Resultsmentioning

confidence: 99%

Randomized control trial outcomes of tranexamic acid combination serum as a depigmenting agent for the use in healthy individuals

Anwar

Wahab

Widita

et al. 2019

Dermatologic Therapy

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To compare the effectiveness of tranexamic acid (TA) combination serum with hydroquinone, the gold standard in whitening agents for healthy populations. This was a three‐arm randomized controlled trial. The subjects were divided into three groups: the first group received 3% TA combination serum (3% TA, 4% galactomyces ferment filtrate, 2% niacinamide, and 4% alpha arbutin), the second group received 2% TA combination serum, and the third group received 4% hydroquinone. One milliliter of each serum was applied on three holes: Hole A, which was located 4 cm from the left cubital fossa, Hole B, which was located 4 cm from the first hole, and Hole C, which was located 4 cm from the right cubital fossa. The skin brightness and pigmentation intensity were evaluated each week for 4 weeks using a chromameter. A total of 44 subjects were recruited for this study. All groups showed a significant improvement in skin brightness and pigmentation intensity after 4 weeks (p < .001). There were no differences between the treatment groups and hydroquinone (p > .05). TA serum (2 and 3%) combined with 4% galactomyces ferment filtrate, niacinamide, and alpha arbutin is an effective depigmenting agent.

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Section: Resultsmentioning

confidence: 99%

Randomized control trial outcomes of tranexamic acid combination serum as a depigmenting agent for the use in healthy individuals

Anwar

Wahab

Widita

et al. 2019

Dermatologic Therapy

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“…Melasma predominantly is clinically characterized by blotchy hyper pigmentation of the face particularly the forehead and malar eminences and to a lesser degree lower portion of the cheeks, chin, the upper lip and the sides of the neck. 6 Treatment of melasma using tranexamic acid is a novel concept. 7 Nijor in Japan first studied and reported action of tranexamic acid on melasma in 1979.…”

Section: Discussionmentioning

confidence: 99%

Safety and Efficacy Profile of Oral Tranexamic Acid v/s Tranexamic Acid Soaks v/s Tranexamic Acid Cream in Treatment of Melasma – A Hospital Based Prospective Randomised Controlled Comparative Study

Patil¹

2018

jmscr

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“…Indikasi umum penggunaan AT adalah untuk pencegahan dan pengobatan perdarahan, 12 akan tetapi, AT juga digunakan sebagai agen pencerah kulit dalam bidang kosmetik. 13,14 Efek AT sebagai pencerah kulit pertama kali ditemukan oleh Nijo di Jepang pada tahun 1979, saat digunakan pada pasien dengan urtikaria kronik. 15 Pemberian AT oral dengan dosis 750 mg/kgBB juga telah terbukti dapat mengurangi keriput akibat kulit kering, menurunkan kadar MMP-1, meningkatkan kandungan kolagen, menurunkan proliferasi sel mast, dan meningkatkan proliferasi sel fibroblas pada mencit hairless tipe Naruto Research Institute Otsuka Atrichia (NOA).…”

Section: Pendahuluanunclassified

“…Hal ini sejalan dengan berbagai penelitian sebelumnya yang telah menggunakan krim AT dengan konsentrasi 2% hingga 5% untuk mengobati melasma dengan mekanisme kerja yang sama. 14,21,22 Pada penelitian ini, krim AT diberikan segera setelah pajanan sinar UVB. Hal ini sejalan dengan metode penelitian yang dilakukan oleh Li et al yang memberikan larutan AT 3% secara intradermal segera dilakukan pajanan sinar UVB.…”

Section: Kelompok Perlakuan Skor Keriput Kadar Mmp-1unclassified

Pengaruh Krim Asam Traneksamat terhadap Pembentukan Keriput dan Kadar Matriks Metaloproteinase-1 pada Mencit (Mus Musculus) Jantan Galur Balb/c yang Dipajan Sinar Ultraviolet B

Citrawan

Suwarsa

Gunawan

et al. 2019

ijcp

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AbstrakPemberian asam traneksamat (AT) per oral telah terbukti dapat mengurangi keriput yang diinduksi oleh kulit kering pada mencit. Namun, dosis oral yang setara terlalu besar untuk digunakan pada manusia dalam jangka panjang karena dapat menimbulkan toksisitas, sehingga perlu dicari sediaan alternatif lain secara topikal seperti sediaan krim. Penelitian ini bertujuan untuk menganalisis pengaruh pemberian krim AT terhadap pembentukan keriput pada kulit mencit jantan galur Balb/c yang dipajan sinar ultraviolet B (UVB). Penelitian dilakukan terhadap 24 ekor mencit di Laboratorium Farmakologi dan Terapi serta Laboratorium Sentral Universitas Padjadjaran pada bulan Februari hingga Mei 2018. Mencit dibagi secara acak ke dalam empat kelompok, yaitu satu kelompok kontrol (P 0 ) hanya mendapatkan pajanan sinar UVB tanpa krim AT dan tiga kelompok perlakuan (P 1 , P 2 , dan P 3 ) mendapat pajanan sinar UVB dan diberikan krim AT dengan konsentrasi masing-masing 3%, 4%, dan 5%. Setelah 10 minggu, dilakukan penilaian kondisi keriput pada kulit punggung mencit berdasarkan metode Bisett, dilanjutkan dengan biopsi kulit punggung mencit untuk pemeriksaan kadar matriks metaloproteinase-1 (MMP-1) dengan teknik western blot (WB). Diperoleh perbedaan nilai rata-rata skor keriput yang bermakna sebesar 2,1±0,105 pada kelompok P 0 , 1,1±0,167 pada P 1 dan P 2 , serta 1,3±0,211 pada P 3 (p=0,005). Diperoleh pula nilai rata-rata kadar MMP-1 yang bermakna, yakni sebesar 0,75±0,08 pada kelompok P 0 , serta 0,54±0,033, 0,40±0,052, dan 0,54±0,072 pada P 1 , P 2 , dan P 3 secara berturut-turut (p=0,008). Berdasarkan hasil tersebut, dapat disimpulkan bahwa pemberian krim AT mampu memperlambat pembentukan keriput dan menurunkan kadar MMP-1 pada kulit punggung mencit jantan galur Balb/c yang dipajan sinar UVB.Kata kunci: Keriput, krim asam traneksamat, matriks metaloproteinase-1, sinar ultraviolet B AbstractOral tranexamic acid (TXA) has been proven to ameliorate wrinkle induced by skin dryness in hairless mouse. However, the equal human oral dose is too high and can induce toxicity if used in long term, and study of topical preparations for wrinkle treatment is limited. Therefore, this study was conducted using topical preparations as an alternative for oral treatment to examine the effects of TXA cream in wrinkle formation. Four weeks old of twenty-four male Balb/c mice, divided into four groups, then 3%, 4% and 5% TXA cream were administered on the back skin of mice in each group shortly after ultraviolet B (UVB) exposure, except for control group that only exposed to UVB lights without given any TXA creams. Wrinkle formation and matrix metalloproteinase (MMP-1) level were observed after 10 weeks of treatments. There were significant differences of wrinkle score, with mean value were 2.1±0.105 for control group, 1.1±0.167 for 3% and 4% groups, and 1.3±0.211 for 5% group (p=0.005). There were also significant differences of MMP-1, with mean value were 0.75±0.08 for control group, 0.54±0.033, 0.40±0.052, and 0.54±0.072 for 3%, 4% and 5% group,...

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Tranexamic Acid in Melasma: A Review

Cited by 22 publications

References 20 publications

Randomized control trial outcomes of tranexamic acid combination serum as a depigmenting agent for the use in healthy individuals

Randomized control trial outcomes of tranexamic acid combination serum as a depigmenting agent for the use in healthy individuals

Safety and Efficacy Profile of Oral Tranexamic Acid v/s Tranexamic Acid Soaks v/s Tranexamic Acid Cream in Treatment of Melasma – A Hospital Based Prospective Randomised Controlled Comparative Study

Pengaruh Krim Asam Traneksamat terhadap Pembentukan Keriput dan Kadar Matriks Metaloproteinase-1 pada Mencit (Mus Musculus) Jantan Galur Balb/c yang Dipajan Sinar Ultraviolet B

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