Tranquilizers in the Management of Alcoholics: A Review of the Literature to 1964. Part II

Benor, Daniel J.; Ditman, Keith S.

doi:10.1002/j.1552-4604.1967.tb00025.x

Cited by 5 publications

(2 citation statements)

References 54 publications

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“…The lack of potentiation of the action of ethanol by chlordiazepoxide has also been previously noted by Hoffer (1962) and by Miller, D'Agnostino and Minsky (1963), who pve both the ethanol and chlordiazepoxide by mouth. There are many recent publications reporting the value of chlordiazepoxide in the management of the acutely ill (Hudson and McGo^an, 1965;Short and Moore, 1965) and the chronic alcoholic (see reviews of Benor and Ditman, 1967;Ditman, 1967). As far as the authors are aware, no worker has reported actual antagonism between the action or chlordiazepoxide and ethanol as found in these studies.…”

Section: Nausea and Vomitingmentioning

confidence: 86%

Clinical Studies of Induction Agents Xxxiv: Further Investigations With Ethanol

Dundee

Isaac

Pandit

et al. 1970

British Journal of Anaesthesia

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A re-evaluation of dilute (8 per cent w/v) ethanol as a sole intravenous anaesthetic agent (with various premedicants), in 300 patients undergoing minor gynaecological surgery, is reported. It confirms that adequate doses will rapidly induce sleep. Sedative or analgesic premedication, notably with promethazine, can make ethanol a more effective and acceptable induction agent, with the maximum dosage (44 g) employed in this study but it was not as reliable for induction as the barbiturates or eugenol derivatives. Its safety in experienced hands was demonstrated and cardiovascular stability was a notable feature. Marked individual variation in response was observed widi this agent, most notably after chlordiazepoxide premedication, where a significantly higher dosage was required to produce sleep than with control (atropine) patients. Though complications were rare during anaesthesia, the incidence of emergence delirium, headache and emetic sequelae with this agent were higher than with the barbiturates or eugenols. Although these could be minimized by heavy opiate premedication, the consequent respiratory depression and prolonged drowsiness made this undesirable. This study has made it possible to observe the various interactions of ethanol with premedicant drugs, and an antagonism by large doses of chlordiazepoxide has been demonstrated.

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