Trans-Aconitic acid, glucosylflavones and hydroxycinnamoyltartaric acids from the leaves of Echinodorus grandiflorus ssp. aureus, a Brazilian medicinal plant

Schnitzler, Miriam; Petereit, Frank; Nahrstedt, Adolf

doi:10.1590/s0102-695x2007000200002

Cited by 28 publications

(19 citation statements)

References 19 publications

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“…(2-O-caffeoyl-(2R,3R)-(+)-tartaric acid) was isolated from Echinodorus grandiflorus ssp. aureus (Alismataceae) (Schnitzler, Petereit, & Nahrstedt, 2007).…”

Section: Chemicalsmentioning

confidence: 99%

Fast determination of N-phenylpropenoyl-l-amino acids (NPA) in cocoa samples from different origins by ultra-performance liquid chromatography and capillary electrophoresis

et al. 2012

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“…(2-O-caffeoyl-(2R,3R)-(+)-tartaric acid) was isolated from Echinodorus grandiflorus ssp. aureus (Alismataceae) (Schnitzler, Petereit, & Nahrstedt, 2007).…”

Section: Chemicalsmentioning

confidence: 99%

Fast determination of N-phenylpropenoyl-l-amino acids (NPA) in cocoa samples from different origins by ultra-performance liquid chromatography and capillary electrophoresis

et al. 2012

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“…In a previous work, we reported flavone-Cglycosides (e.g., swertisin, swertiajaponin, isoorientin, and isovitexin), diterpenes, and aconitic acid as the antiedematogenic constituents of the species [8]. The chemistry of the species has been thoroughly investigated and comprises, besides the abovementioned compounds, hydroxycinnamoyltartaric acids like chicoric, fertaric, and caftaric acids [9] along with steroids, cembrane, and clerodane diterpenes [10]. Given the traditional use of E. grandiflorus, we further investigated the potential of the species for the treatment of RA and the relevance of its flavonoids for the anti-inflammatory effect by looking at the activity of a 70% ethanol extract…”

mentioning

confidence: 99%

Effect of the Hydroethanolic Extract from Echinodorus grandiflorus Leaves and a Fraction Enriched in Flavone-C-Glycosides on Antigen-Induced Arthritis in Mice

et al. 2016

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The leaves of Echinodorus grandiflorus are traditionally used in Brazil to treat several inflammatory conditions, including arthritis. This study aimed to investigate the antiarthritis activity of the 70% ethanol extract of E. grandiflorus leaves and a standardized flavonoid-rich fraction in an antigen-induced arthritis model in mice. Previously immunized mice were treated per os with saline (control group), 70% ethanol extract (100-1000 mg/kg), or a flavonoid-rich fraction (0.7-7.2 mg/kg) 40 minutes before and 3 and 6 hours after the challenge with antigen into the knee joint. The administration of the 70% ethanol extract and flavonoid-rich fraction to mice significantly reduced neutrophil recruitment to the joint cavity and in periarticular tissue. The levels of chemokine (C-X-C motif) ligand 1, tumor necrosis factor-α, and interleukin-1β quantified by the enzyme-linked immunosorbent assay (ELISA) in the periarticular tissue were also diminished in mice treated with the 70% ethanol extract and flavonoid-rich fraction, as well as mechanical hypernociception. Histological analysis confirmed that both the 70% ethanol extract and flavonoid-rich fraction suppressed joint inflammation and inhibited cartilage and bone destruction when compared to the control group. Our results demonstrate, for the first time, that E. grandiflorus has anti-inflammatory activity in an experimental arthritis model and highlights the role of flavonoids in the observed response.

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“…Phytochemical evaluation of extracts made from leaves has led to the identification of cembrane and clerodane-type diterpenoids, sesquiterpenes and flavonoids (Schnitzler et al 2007, Costa et al 1999, Tanaka et al 1997, Manns and Hartmann 1993). Maillard's products, those originated from the reaction between aminoacids and reducing sugars upon heating, are well known mutagenic compounds and their formation in food products is kept to a minimum to prevent loss of quality and nutritional properties (Powrie et al 1986).…”

Section: Introductionmentioning

confidence: 99%

Genotoxic Maillard byproducts in current phytopharmaceutical preparations of Echinodorus grandiflorus

Lima

Waldhelm

Alves

et al. 2014

An. Acad. Bras. Ciênc.

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Extracts of Echinodorus grandiflorus obtained from dried leaves by three different techniques were evaluated by bacterial lysogenic induction assay (Inductest) in relation to their genotoxic properties. Before being added to test cultures, extracts were sterilized either by steam sterilization or ultraviolet light. Only the extracts prepared by infusion and steam sterilized have shown genotoxic activity. The phytochemical analysis revealed the presence of the flavonoids isovitexin, isoorientin, swertisin and swertiajaponin, isolated from a genotoxic fraction. They were assayed separately and tested negative in the Inductest protocol. The development of browning color and sweet smell in extracts submitted to heat, prompted further chemical analysis in search for Maillard´s reaction precursors. Several aminoacids and reducing sugars were cast in the extract. The presence of characteristic Maillard´s melanoidins products was determined by spectrophotometry in the visible region and the inhibition of this reaction was observed when its characteristic inhibitor, sodium bisulfite, was added prior to heating. Remarkably, this is the first paper reporting on the appearance of such compounds in a phytomedicine preparation under a current phytopharmaceutical procedure. The genotoxic activity of such heat-prepared infusions imply in some risk of developing degenerative diseases for patients in long-term, uncontrolled use of such phytomedicines.

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Trans-Aconitic acid, glucosylflavones and hydroxycinnamoyltartaric acids from the leaves of Echinodorus grandiflorus ssp. aureus, a Brazilian medicinal plant

Cited by 28 publications

References 19 publications

Fast determination of N-phenylpropenoyl-l-amino acids (NPA) in cocoa samples from different origins by ultra-performance liquid chromatography and capillary electrophoresis

Fast determination of N-phenylpropenoyl-l-amino acids (NPA) in cocoa samples from different origins by ultra-performance liquid chromatography and capillary electrophoresis

Effect of the Hydroethanolic Extract from Echinodorus grandiflorus Leaves and a Fraction Enriched in Flavone-C-Glycosides on Antigen-Induced Arthritis in Mice

Genotoxic Maillard byproducts in current phytopharmaceutical preparations of Echinodorus grandiflorus

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