Trans-astaxanthin attenuates lipopolysaccharide-induced neuroinflammation and depressive-like behavior in mice

Jiang, Xi; Chen, Lei; Shen, Lailai; Chen, Ziwei; Li, Xu; Zhang, Jia-Jia; Yu, Xuefeng

doi:10.1016/j.brainres.2016.08.029

Cited by 47 publications

(33 citation statements)

References 53 publications

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“…The present results showed that a decrease in the BDNF level in the PFC was observed, and pretreatment with AST reversed the reduction of BDNF in this diabetes co-morbidity with depression model. A few studies demonstrate that AST decreases depressive-like behaviors induced by LPS or in diabetic mice via its potent anti-inflammatory property (Jiang et al, 2016;Zhou et al, 2017). Thus, the increased BDNF level in the PFC following treatment with AST indicated that neuroplasticity regulation by AST is crucial for its antidepressant activity.…”

Section: Discussionmentioning

confidence: 99%

“…Accumulating evidence shows that AST provides neuroprotection against diabetes-induced sickness behavior through inhibiting inflammation (Ying et al, 2015), attenuating oxidative stress (Li et al, 2016), and causing the expression of caspase-3/9 in the cerebral cortex and hippocampus . A few studies demonstrate that AST decreases depressive-like behaviors stimulated by LPS or in diabetic mice via its potent antiinflammatory effects Jiang et al, 2016;Zhou et al, 2017), and the evidence also shows that the serotonergic system may be involved in the antidepressant-like effect of AST (Jiang et al, 2016). Although AST improves both depression and diabetes, the underlying mechanism is unclear.…”

Section: Introductionmentioning

confidence: 99%

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Preventive and Therapeutic Effects of Astaxanthin on Depressive-Like Behaviors in High-Fat Diet and Streptozotocin-Treated Rats

et al. 2020

Front. Pharmacol.

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The comorbidity of diabetes and depression has a negative impact on both lifestyle and quality of life. Astaxanthin (AST) has been demonstrated to improve glucose metabolism and has antidepressant-like effects, but it is not clear whether AST has potential for preventing depression in diabetes. The aim of this study is to observe the preventive and therapeutic effects of AST on glucose metabolism or depressive-like behaviors in a diabetic rat model produced by feeding with a high-fat diet for 10 weeks followed by injection of 25 mg/kg streptozotocin (STZ). Preventive treatment with AST at doses of 7.5, 15, and 25 mg/kg/day was given by intragastric gavage 4 weeks before STZ injection. Preventive plus therapeutic treatment also involved therapeutic AST treatments for 6 more weeks after STZ injection, whereas therapeutic-only treatment involved only the 6-week post-STZ treatment. Depressive-like behaviors were evaluated at the end of the treatment by using open field, locomotor activity, elevated plus maze, and forced swimming tests. Preventive and therapeutic treatment with AST both reduced the level of fasting glucose, improved glucose tolerance, and decreased total TCh and TG in diabetic rats. Preventive or preventative plus therapeutic treatment with AST decreased the immobility time and increased the time spent in the open arms of an elevated plus maze and locomotor activity in diabetic rats. However, therapeutic treatment with AST alone failed to affect the depressive-like behaviors. Preventive or preventative plus therapeutic treatment with AST at doses of 15 or 25 mg/kg significantly increased the expression of pERK, pAKT, pCREB, and BDNF in the prefrontal cortex (PFC) in diabetic rats. In contrast, therapeutic treatment with 25 mg/kg AST alone increased the expression of pERK in the PFC. This study indicates that AST may be used as a preventive or therapeutic approach for comorbidity of diabetes and depression.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Preventive and Therapeutic Effects of Astaxanthin on Depressive-Like Behaviors in High-Fat Diet and Streptozotocin-Treated Rats

et al. 2020

Front. Pharmacol.

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“…Base on this advantage, the neuroprotective effects of trans-astaxanthin have been confirmed in several neurodegenerative disorders, such as Alzheimer’s disease and Parkinson’s disease [9–11]. More recently, our study showed that trans-astaxanthin can ameliorate lipopolysaccharide (LPS)-induced behavioral deficits, such as depressive-like behavior [12]. Moreover, previous study suggested that trans-astaxanthin can antagonize ethanol-induced depression [13].…”

Section: Introductionmentioning

confidence: 95%

The antidepressant-like effect of trans-astaxanthin involves the serotonergic system

Jiang

Zhu

et al. 2017

Oncotarget

Self Cite

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The antidepressant-like effect of trans-astaxanthin, a compound present rich in algae, was evaluated through behavioral and neurochemical methods. Results showed that trans-astaxanthin treatment significantly decreased the immobility time in force swim test and tail suspension test, but did not influence locomotor activity. Trans-astaxanthin treatment did not effectively antagonize hypothermia and ptosis induced by reserpine. However, pre-treatment with para-chlorophenylalanine abolished the anti-immobility effect of trans-astaxanthin in force swim and tail suspension test. These results suggested that the mechanism of antidepressant-like effect of trans-astaxanthin may involve the serotonergic system, but not noradrenaline system. This hypothesis was confirmed by neurochemical assays which showed that trans-astaxanthin increased serotonin levels in the hippocampus, frontal cortex, striatum and hypothalamus. Furthermore, our data suggested that trans-astaxanthin decreased indoleamine 2, 3-dioxygenase activity in the hippocampus, frontal cortex and hypothalamus. Inhibition of indoleamine 2,3-dioxygenase activity subsequently decreased the kynurenine/tryptophan ratio and increased the serotonin/tryptophan ratio in these brain regions. Taken together, these findings indicate that the antidepressant-like effect of trans-astaxanthin involves the serotonergic system.

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“…The enantiomers displayed typical antipodal ECD curves ( Fig. 3) 23 D À174). Furthermore, the conguration of 2b was determined as 7S,8S,7 0 S,8 0 S on the basis of the good agreement with calculated ECD spectra of (7S,8S,7 0 S,8 0 S)-2, and the conguration of 2a was determined to be 7R,8R,7 0 R,8 0 R. Finally, the enantiomers 2a and 2b were named as (+)-asarolignan B and (À)-asarolignan B, respectively.…”

Section: Introductionmentioning

confidence: 97%

“…22 TNF-a is one of the critical proin-ammatory cytokines. 23,24 To a certain extent, reducing TNFa levels has the potential to medicate anti-neuroinammation action. In our study, all the isolated compounds were evaluated for anti-neuroinammatory activities on TNF-a production in LPS-activated BV-2 cells.…”

Section: Introductionmentioning

confidence: 99%

Anti-neuroinflammatory asarone derivatives from the rhizomes of Acorus tatarinowii

Qin

Zhang

et al. 2017

RSC Adv.

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Trans-astaxanthin attenuates lipopolysaccharide-induced neuroinflammation and depressive-like behavior in mice

Cited by 47 publications

References 53 publications

Preventive and Therapeutic Effects of Astaxanthin on Depressive-Like Behaviors in High-Fat Diet and Streptozotocin-Treated Rats

Preventive and Therapeutic Effects of Astaxanthin on Depressive-Like Behaviors in High-Fat Diet and Streptozotocin-Treated Rats

The antidepressant-like effect of trans-astaxanthin involves the serotonergic system

Anti-neuroinflammatory asarone derivatives from the rhizomes of Acorus tatarinowii

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