Transabdominal chorionic villi sampling for first trimester fetal diagnosis. First 26 pregnancies followed to term

Smidt‐Jensen, Steen; Hahnemann, Niels; Hariri, Jalil; Jensen, Peter K.A.; Therkelsen, A. J.

doi:10.1002/pd.1970060208

Cited by 32 publications

(12 citation statements)

References 8 publications

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“…To our knowledge, all the babies born up to date were normal. This is in agreement with previous reports (Smidt-Jensen et al, 1986;Los et al, 1989) that there seems to be no correlation between exsanguination of the fetus due to voluminous feto-maternal transfusion at the time of CVS and subsequent fetal development.…”

Section: Discussionsupporting

confidence: 93%

Fetal nucleated erythrocytes (NRBCS) in chorionic villus sample supernatant fluids: an additional source of fetal material for karyotype confirmation

Mavrou¹,

Zheng

Kοlialexi

et al. 1997

Prenat. Diagn.

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Fetal erythrocytes leak from the fetal capillaries at the time of chorionic villus removal. The purpose of this study was to determine if fetal nucleated erythrocytes (NRBCs) could be isolated from the chorionic villus sampling (CVS) supernatant fluid and used as an additional source of fetal material in order to confirm the fetal karyotype in cases of CVS mosaicism. One hundred CVS supernatant fluids were studied by simultaneous immunophenotyping, using a mouse antifetal haemoglobin antibody, UCHγ, combined with fluorescent in situ hybridization (FISH) analysis using X‐ and Y‐specific DNA probes. A chromosome 18 probe was also used in the case of a known male fetus with trisomy 18. Fetal haemoglobin (HbF)‐positive cells were identified in 73 supernatant fluids and HbF‐positive nucleated cells were present in 60 samples. The number of cells detected per sample showed great variation among the individual samples. FISH analysis was performed in 41 cases. FISH prediction of the fetal gender was concordant with the CVS karyotype in all cases, and the fetal trisomy 18 was correctly verified. In five cases in which Y sequences were detected, a small number of HbF‐positive cells with two X signals were also identified; interestingly, in three of the five cases, the mother was a β‐thalassaemia carrier. This technique can be used as a quick and accurate method for the immediate verification of CVS results in cases of mosaicism, thus avoiding second‐trimester amniocentesis. © 1997 John Wiley & Sons, Ltd.

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Section: Discussionsupporting

confidence: 93%

Fetal nucleated erythrocytes (NRBCS) in chorionic villus sample supernatant fluids: an additional source of fetal material for karyotype confirmation

Mavrou¹,

Zheng

Kοlialexi

et al. 1997

Prenat. Diagn.

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“…Since the introduction of the transabdominal approach to CVS, the technique has undergone few modifications3, 4. Most centers and operators use a single‐ or double‐needle system, and once the needle is within the chorion a syringe is attached to the needle and discontinuous negative pressure is applied, either manually or with the help of a hand grip (‘pistol’), to achieve adequate aspiration of the villi.…”

Section: Discussionmentioning

confidence: 99%

A randomized study to assess two different techniques of aspiration while performing transabdominal chorionic villus sampling

Battagliarin

Lanna

Coviello

et al. 2008

Ultrasound in Obstet & Gyne

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“…The transabdominal route, proposed in 1984 by Smidt-Jensen and Hahnemann (19841, has become widespread (Gustavii et af., 1986;Maxwell et al, 1986;Smidt-Jensen et al, 1986;Brambati et al, 1987;Smidt-Jensen et al, 1987;Macltenzie et al, 1988;Therkelsen et d., 1988;Elias et af., 1989); 8460 attempts were recently reported by Jackson (1989). Since January 1988, 210 tests were carried out in the authors' prenatal unit.…”

Section: Discussionmentioning

confidence: 99%

Risks of transabdominal chorionic villus sampling before the 12th week of amenorrhea

et al. 1990

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The authors report on a series of 210 chorion villus sampling diagnoses made with a needle by the transabdominal route. The rate of fetal loss was 4.2 per cent. Placental localization was important: fetal losses were 8 per cent when the placenta was strictly posterior (transamniotic route), whereas it was only 1.6 per cent when it was not posterior. Moreover, all fetal losses occurred (apart from one at 12.5 weeks of amenorrhea) before the 12th week of amenorrhea. The authors suggest that choriocentesis by the transabdominal route should not be performed before the 12th week of amenorrhea, and that the amniotic membrane should not be disturbed before the 13th week of amenorrhea.

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Transabdominal chorionic villi sampling for first trimester fetal diagnosis. First 26 pregnancies followed to term

Cited by 32 publications

References 8 publications

Fetal nucleated erythrocytes (NRBCS) in chorionic villus sample supernatant fluids: an additional source of fetal material for karyotype confirmation

Fetal nucleated erythrocytes (NRBCS) in chorionic villus sample supernatant fluids: an additional source of fetal material for karyotype confirmation

A randomized study to assess two different techniques of aspiration while performing transabdominal chorionic villus sampling

Risks of transabdominal chorionic villus sampling before the 12th week of amenorrhea

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