oil embolization has been recently used for closure of patent ductus arteriosus (PDA), but because large PDA are difficult to close with this technique, it is generally used when the duct diameter is less than 3.5 mm. 1 However, there are some case reports in which large PDA were closed by placing more than 2 coils. 2,3 Serious complications of coil embolization are coil migration and hemolysis caused by a residual shunt, 4,5 the latter being reported as the major complication with approximately 1-2% occurrence. 2,6,7 Although a hemolytic complication usually needs additional coil embolization 4,5 or surgical treatment, medical treatment may be preferable when the residual shunt is minimal and the degree of hemolysis is mild. We report 2 cases of large PDA that were treated by multiple coil embolization, complicated by hemolysis, but successfully managed by medical treatment.
Case Reports
Case 1A 67-year-old woman was admitted for evaluation of dyspnea on exersion, paroxysmal atrial fibrillation (AF), and a continuous murmur of grade 4/6 in the second left intercostal space. Physical examination revealed blood pressure of 120/60 mmHg under medical treatment. The ECG finding was left ventricular hypertrophy with ST-T abnormality. Chest X-ray (CXR) showed moderate cardiomegaly with increased pulmonary vascular markings. Color Doppler echocardiography showed a shunt flow in the pulmonary artery. Right heart catheterization revealed the pulmonary artery pressure was 30/14 mmHg and there was an oxygen step-up at the level of the main pulmonary artery. The ratio of pulmonary to systemic flow was 2.0. Aortography revealed the shunt flow and a type A PDA 8 with a minimum ductal diameter of 5.3 mm. Left ventriculography showed an increase in ventricular volume, but the ventricular wall motion and coronary angiogram were normal.Because the ductal diameter was relatively large to be closed by embolization with one coil, we planned to deliver multiple Jackson detachable coils (MWCE-8-PDA5; diameter 8 mm and 5 loops, Cook Cardiology, Bjaeverskov, Denmark). Two 7Fr catheters were inserted into the femoral vein and advanced from the pulmonary artery through the Two adult cases of relatively large patent ductus arteriosus (PDA) were treated by coil embolization, but were complicated by hemolysis that was successfully managed by medical treatment. Case 1 was a 67-year-old woman and Case 2 was a 71-year-old woman with a PDA of minimal diameter of 5.3 mm and 5.5 mm, respectively. The approach was via the pulmonary artery and 2 coils were delivered simultaneously into the ductus, known as the 'kissing coil technique'. Although immediately after the procedure only a small residual shunt was revealed by aortogram, hemolysis occurred for several hours after the procedure in both cases. A hemolytic complication usually needs additional coil embolization or surgical treatment, but in these 2 cases it was successfully treated by haptoglobin infusion to prevent nephropathy and by antiplasmin infusion to promote thrombus formation. Hemolyt...