Poly(3,4-ethylenedioxythiophene): poly(styrenesulfonate) (PEDOT:PSS) is the most commonly used hole transport layer (HTL) in inverted (p-i-n) structured perovskite solar cells (PSCs) due to remarkable transparency and conductivity. Despite high transparency and conductivity, PEDOT:PSS has some concealed problems such as acidity, hygroscopic nature, lower work function than the ionization potential of perovskite, and poor electron blocking capability. All these properties hinder the efficient charge extraction and transport from perovskite absorber to ITO. In addition, acidic and hygroscopic nature of PEDOT:PSS can corrode the ITO electrode and degrade the moisture sensitive PSK layer, respectively. These can degrade the long-term stability and lower the performance of PSCs. Therefore, tailoring PEDOT:PSS HTL is essential for achieving highly efficient PSCs to mitigate these drawbacks. This review article gives an overview of approaches tailoring PEDOT:PSS that can minimize the limitations as HTL to improve the performance of PSCs. These include solvent treatment, composite structure, doping, and bi-layer structure PEDOT:PSS. In addition, the roles of tailored PEDOT:PSS HTL was understood in perovskite solar cells.