Transcription Factor RREB1: from Target Genes towards Biological Functions

Deng, Yanan; Xia, Zijing; Zhang, Peng; Ejaz, Samina; Liang, Shufang

doi:10.7150/ijbs.40834

Cited by 46 publications

(33 citation statements)

References 76 publications

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“…Rreb1 is a context-dependent transcriptional repressor or activator ( Deng et al, 2020 ). To define the gene expression changes associated with a developmental loss of Rreb1 we performed RNA-sequencing of Rreb1 -/- embryos and compared them to wild-type ( Rreb1 +/+ ) transcriptomes.…”

Section: Resultsmentioning

confidence: 99%

“…Ras-responsive element-binding protein 1 (RREB1) is a zinc-finger transcription factor that acts downstream of RAS ( Thiagalingam et al, 1996 ). It is evolutionarily conserved ( Ming et al, 2013 ), widely expressed ( Fujimoto-Nishiyama et al, 1997 ), can function both as a transcriptional repressor and activator ( Deng et al, 2020 ), and interacts with several signaling pathways, including EGFR/MAPK ( Kim et al, 2020 ) and JNK/MAPK ( Melani et al, 2008 ; Reed et al, 2001 ), which regulate RREB1 through phosphorylation, and JAK/STAT ( Melani et al, 2008 ), TGF-β/SMAD ( Su et al, 2020 ), Notch, and Sonic Hedgehog ( Sun and Deng, 2007 ), which cooperate with RREB1 in transcriptional regulation. These properties suggest that RREB1 plays key contextual biological roles.…”

Section: Introductionmentioning

confidence: 99%

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The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos

Morgani

Nichols

et al. 2021

eLife

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Ras-responsive element-binding protein 1 (Rreb1) is a zinc-finger transcription factor acting downstream of RAS signaling. Rreb1 has been implicated in cancer and Noonan-like RASopathies. However, little is known about its role in mammalian non-disease states. Here, we show that Rreb1 is essential for mouse embryonic development. Loss of Rreb1 led to a reduction in the expression of vasculogenic factors, cardiovascular defects, and embryonic lethality. During gastrulation, the absence of Rreb1 also resulted in the upregulation of cytoskeleton-associated genes, a change in the organization of F-ACTIN and adherens junctions within the pluripotent epiblast, and perturbed epithelial architecture. Moreover, Rreb1 mutant cells ectopically exited the epiblast epithelium through the underlying basement membrane, paralleling cell behaviors observed during metastasis. Thus, disentangling the function of Rreb1 in development should shed light on its role in cancer and other diseases involving loss of epithelial integrity.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos

Morgani

Nichols

et al. 2021

eLife

View full text Add to dashboard Cite

show abstract

“…Rreb1 is a transcription factor that functions as a context-dependent repressor or activator (Deng et al, 2020). To define the transcriptional changes associated with a developmental loss of Rreb1 and gain insights into its mechanism of action, we performed RNA-sequencing of Rreb1 −/− embryos and compared them to wild-type ( Rreb1 +/+ ) transcriptomes.…”

Section: Resultsmentioning

confidence: 99%

The transcription factor Rreb1 regulates epithelial architecture and invasiveness in gastrulating mouse embryos

Morgani

Nichols

et al. 2020

Preprint

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Ras-responsive element-binding protein 1 (Rreb1) is a zinc-finger transcription factor downstream of RAS signaling. Rreb1 has been implicated in cancer but little is known about its role in mammalian non-disease states. Here, we found that Rreb1 is essential for mouse embryonic development. Loss of Rreb1 led to a reduction in the expression of vasculogenesis factors, cardiovascular defects and embryonic lethality. During gastrulation, the absence of Rreb1 also resulted in the upregulation of cytoskeleton-associated genes, a change in the organization of F-ACTIN and adherens junctions within the pluripotent epiblast, and perturbed epithelial architecture characterized by irregular tissue folding and abnormal accumulations of cells. Moreover, Rreb1 mutant cells ectopically exited the epiblast epithelium through the underlying basement membrane, paralleling cell behaviors observed during metastasis. Thus, disentangling the function of Rreb1 in development could shed light on its role in cancer and other diseases involving loss of epithelial integrity.

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“…In addition, ROS are mediators of the MAPK pathway, which has been shown to affect follicle maturation [ 39 , 40 ]. Another candidate gene ras responsive element binding protein ( RREB1 ) is a downstream effector of the MAPK [ 41 ]. Overall, changes in ROS levels can affect the outcomes of the MAPK pathway, thereby influencing cell proliferation and the likelihood of ovulation.…”

Section: Discussionmentioning

confidence: 99%

Genome-Wide Association Analyses of Fertility Traits in Beef Heifers

Stegemiller

Murdoch

Rowan

et al. 2021

Genes

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The ability of livestock to reproduce efficiently is critical to the sustainability of animal agriculture. Antral follicle count (AFC) and reproductive tract scores (RTS) can be used to estimate fertility in beef heifers, but the genetic mechanisms influencing variation in these measures are not well understood. Two genome-wide association studies (GWAS) were conducted to identify the significant loci associated with these traits. In total, 293 crossbred beef heifers were genotyped on the Bovine GGP 50K chip and genotypes were imputed to 836,121 markers. A GWAS was performed with the AFC phenotype for 217 heifers with a multi-locus mixed model, conducted using the year, age at time of sampling and principal component analysis groupings as the covariates. The RTS GWAS was performed with 289 heifers using an additive correlation/trend test comparing prepubertal to pubertal heifers. The loci on chromosomes 2, 3 and 23 were significant in the AFC GWAS and the loci on chromosomes 2, 8, 10 and 11 were significant in the RTS GWAS. The significant region on chromosome 2 was similar between both analyses. These regions contained genes associated with cell proliferation, transcription, apoptosis and development. This study proposes candidate genes for beef cattle fertility, although future research is needed to elucidate the precise mechanisms.

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Transcription Factor RREB1: from Target Genes towards Biological Functions

Cited by 46 publications

References 76 publications

The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos

The transcription factor Rreb1 regulates epithelial architecture, invasiveness, and vasculogenesis in early mouse embryos

The transcription factor Rreb1 regulates epithelial architecture and invasiveness in gastrulating mouse embryos

Genome-Wide Association Analyses of Fertility Traits in Beef Heifers

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