1986
DOI: 10.1128/mcb.6.2.601
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Transcription of the histone H5 gene is not S-phase regulated.

Abstract: Levels of the tissue-specific linker histone H5 are elevated in mgture erythroid cells as compared with levels in dividing cells of the same lineage. We examined levels of H5 mRNA in relation to the cell cycle in early erythroid cells transformed by avian erythroblastosis virus to determine whether the gene for this unusual histone is S-phase regulated. Northern blotting analyses revealed that during the cell cycle steady-state levels of H5 mRNA remained relatively constant in contrast to levels of the major c… Show more

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Cited by 29 publications
(46 citation statements)
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“…Aphidicolin, an inhibitor of DNA polymerase a (reviewed in reference 24), is known to influence, as well as other inhibitors of DNA synthesis, both the transcription rate of the histone genes and the levels of histone mRNA (14,23).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…Aphidicolin, an inhibitor of DNA polymerase a (reviewed in reference 24), is known to influence, as well as other inhibitors of DNA synthesis, both the transcription rate of the histone genes and the levels of histone mRNA (14,23).…”
Section: Resultsmentioning
confidence: 99%
“…3) (14). In view of these properties, we examined the temporal relationship between the transcription of several histone genes (Hi, H3, H2A, and H5) and that of a gene for a differentiated cell product (_A-globin).…”
Section: Resultsmentioning
confidence: 99%
“…The replacement or basal histone gene variants (49) and avian histone H5 (7) are notable exceptions to this rule. The cell cycle regulation of histone mRNA expression has been investigated in several systems and is likely to involve changes in the rate of gene transcription (14,17,32), changes in mRNA stability (15,17,40), and structural features of the mRNA transcripts and their templates (4,25).…”
mentioning
confidence: 99%
“…One of the cell cycle-independent variants is the human H3.3, which has an intron and encodes polyadenylated mRNA (46). The best-known examples of cell type-specific histones are the avian erythrocyte-specific H5 (11,45) and the mammalian testis-specific histones (4,27). During spermatogenesis, testis-specific histones (TH1, TH2A, and TH2B) are synthesized in the mammalian testis in the absence of DNA replication, and these histones replace the corresponding somatic histones (6,27).…”
mentioning
confidence: 99%