Transcriptional profiles and common genes link lung cancer with the development and severity of COVID-19

Cury, SS.; Oliveira, JS.; Biagi-Júnior, CAO.; WA, Silva Jr; Reis, PP.; Cabral-Marques, Otávio; Hasimoto, EN.; Freire, PP.; Carvalho, RF.

doi:10.1016/j.gene.2022.147047

Cited by 3 publications

(2 citation statements)

References 61 publications

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“…PTTG1, CENPF, KIF4, KIF11, NUSAP1, and TPX2 have also been implicated in many biological functions, such as DNA repair, organ development, and regulation of mitosis (Försti et al, 2016). CENPF was viewed as a prognostic indicator of lung cancer patients with COVID-19 infection (Cury et al, 2023). TPX2 and KIF11 were upregulated in peripheral blood mononuclear cells and contributed to diagnosing and managing COVID-19 patients (Hasan et al, 2022).…”

Section: Discussionmentioning

confidence: 99%

Exploration and verification of COVID-19-related hub genes in liver physiological and pathological regeneration

Shi

Li²,

Yuan³

et al. 2023

Front. Bioeng. Biotechnol.

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Objectives An acute injury is often accompanied by tissue regeneration. In this process, epithelial cells show a tendency of cell proliferation under the induction of injury stress, inflammatory factors, and other factors, accompanied by a temporary decline of cellular function. Regulating this regenerative process and avoiding chronic injury is a concern of regenerative medicine. The severe coronavirus disease 2019 (COVID-19) has posed a significant threat to people’s health caused by the coronavirus. Acute liver failure (ALF) is a clinical syndrome resulting from rapid liver dysfunction with a fatal outcome. We hope to analyze the two diseases together to find a way for acute failure treatment.Methods COVID-19 dataset (GSE180226) and ALF dataset (GSE38941) were downloaded from the Gene Expression Omnibus (GEO) database, and the “Deseq2” package and “limma” package were used to identify differentially expressed genes (DEGs). Common DEGs were used for hub genes exploration, Protein-Protein Interaction (PPI) network construction, Gene Ontology (GO) functional enrichment, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment. The real-time reverse transcriptase-polymerase chain reaction (RT-qPCR) was used to verify the role of hub genes in liver regeneration during in vitro expansion of liver cells and a CCl4-induced ALF mice model.Results: The common gene analysis of the COVID-19 and ALF databases revealed 15 hub genes from 418 common DEGs. These hub genes, including CDC20, were related to cell proliferation and mitosis regulation, reflecting the consistent tissue regeneration change after the injury. Furthermore, hub genes were verified in vitro expansion of liver cells and in vivo ALF model. On this basis, the potential therapeutic small molecule of ALF was found by targeting the hub gene CDC20.Conclusion We have identified hub genes for epithelial cell regeneration under acute injury conditions and explored a new small molecule Apcin for liver function maintenance and ALF treatment. These findings may provide new approaches and ideas for treating COVID-19 patients with ALF.

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Section: Discussionmentioning

confidence: 99%

Exploration and verification of COVID-19-related hub genes in liver physiological and pathological regeneration

Shi

Li²,

Yuan³

et al. 2023

Front. Bioeng. Biotechnol.

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“…However, the effects of TRIB3 on the replication of BVDV, JEV and Zika virus remain to be determined [ 40 , 41 ]. Recently, Carvalho et al found that the decreased expression of TRIB3 in the aged lung may be associated with more severe cases of the COVID-19, and they predicted that TRIB3 may interact with the nucleocapsid protein and the RNA-dependent RNA polymerase of SARS-CoV-2 to inhibit the virus replication [ 42 , 43 ].…”

Section: Introductionmentioning

confidence: 99%

Tribbles pseudokinase 3 promotes enterovirus A71 infection via dual mechanisms

Wang,

Li,

Cui

et al. 2024

Emerging Microbes & Infections

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Enterovirus A71 (EV-A71) is the main pathogen causing hand, foot and mouth disease (HFMD) in children and occasionally associated with neurological diseases such as aseptic meningitis, brainstem encephalitis (BE) and acute flaccid paralysis. We report here that cellular pseudokinase tribbles 3 (TRIB3) facilitates the infection of EV-A71 via dual mechanisms. In one hand, TRIB3 maintains the metabolic stability of scavenger receptor class B member 2 (SCARB2), the bona fide receptor of EV-A71, to enhance the infectious entry and spreading of the virus. On the other hand, TRIB3 facilitates the replication of EV-A71 RNA in a SCARB2-independent manner. The critical role of TRIB3 in EV-A71 infection and pathogenesis was further demonstrated in vivo in mice. In comparison to wild-type C57BL/6 mice, EV-A71 infection in TRIB3 knockdown mice ( Trib3 +/− ) resulted in significantly lower viral loads in muscular tissues and reduced lethality and severity of clinical scores and tissue pathology. In addition, TRIB3 also promoted the replication of coxsackievirus B3 (CVB3) and coxsackievirus A16 (CVA16) in vitro . In conclusion, our results suggest that TRIB3 is one of key host cellular proteins required for the infection and pathogenesis of EV-A71 and some other human enteroviruses and may thus be a potential therapeutic target for combating the infection of those viruses.

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Smoking behaviors, physical activities, pulmonary diseases and COVID-19 severity: A Mendelian randomization study

Zheng,

Chen,

Zhuang

et al. 2024

Medicine

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Smoking behaviors, physical activities, and pulmonary diseases have been revealed to be associated with COVID-19 severity through observational research. The possible causative effect remains undetermined. To investigate this, we thus carried out a Mendelian randomization (MR) analysis. We chose genetic variants from genome-wide association studies that are strongly linked to 5 exposures related to smoking, 1 exposure related to drinking, 3 levels of physical activity, and 3 pulmonary diseases. The COVID-19 Host Genetics Initiative provided summary-level data for severe COVID-19 (13,769 cases and 1,072,442 noncases), hospitalized COVID-19 (32,519 cases and 2,062,805 noncases), and COVID-19 susceptibility (122,616 cases and 2,475,240 noncases). Univariate and multivariate MR analyses were carried out. Significant associations were found between severe COVID-19 and cigarette smoking per day (OR = 1.357, 95% CI: 1.087–1.694), lifetime smoking index (OR = 2.277, 95% CI: 1.602–3.325), and interstitial lung disease (OR = 1.23, 95% CI: 1.112–1.362), hospitalized COVID-19 and lifetime smoking index (OR = 2.199, 95% CI: 1.738–2.781), smoking initiation (OR = 1.419, 95% CI: 1.230–1.637), and interstitial lung disease (OR = 1.146, 95% CI: 1.082–1.214), as well as COVID-19 susceptibility and lifetime smoking index (OR = 1.39, 95% CI: 1.252–1.543), smoking initiation (OR = 1.235, 95% CI: 1.163–1.311), and duration of vigorous activity per day (OR = 0.733, 95% CI: 0.574–0.935). Duration of vigorous activity per day was suggestively inversely linked to hospitalized COVID-19 (OR = 0.434, 95% CI: 0.221–0.853) and severe COVID-19 (OR = 0.323, 95% CI: 0.123–0.850). The association for lifetime smoking index remained consistent with severe COVID-19, hospitalized COVID-19, and COVID-19 susceptibility in multivariable MR analysis. Genetic liability to lifetime smoking index mediated the interstitial lung disease effects on severe COVID-19 risk (21.0%) and hospitalized COVID-19 risk (14.4%). This study identified several smoking behaviors, duration of vigorous activity per day, and interstitial lung disease that may be causally related to COVID-19 severity.

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Transcriptional profiles and common genes link lung cancer with the development and severity of COVID-19

Cited by 3 publications

References 61 publications

Exploration and verification of COVID-19-related hub genes in liver physiological and pathological regeneration

Exploration and verification of COVID-19-related hub genes in liver physiological and pathological regeneration

Tribbles pseudokinase 3 promotes enterovirus A71 infection via dual mechanisms

Smoking behaviors, physical activities, pulmonary diseases and COVID-19 severity: A Mendelian randomization study

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