Transcriptional Regulation of Fruit Ripening by Tomato FRUITFULL Homologs and Associated MADS Box Proteins

Fujisawa, Masaki; Shima, Yoshihiro; Nakagawa, Hiroyuki; Kitagawa, Mikiya; Kimbara, Junji; Nakano, Tsutomu; Kasumi, Takafumi; Ito, Yasuhiro

doi:10.1105/tpc.113.119453

Cited by 193 publications

(173 citation statements)

References 57 publications

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“…In addition, the orthologs of FUL in Arabidopsis, FUL1/ TM4 and FUL2/MBP7, can bind to RIN, but not directly to TAGL1 (Leseberg et al 2008;Bemer et al 2012;Shima et al 2013). Other work using gel retardation assays indicate the likely existence of higher order complexes including RIN, TAGL1, FUL1, and FUL2 (Fujisawa et al 2014). The fact that the rin mutant, TAGL1 RNAi lines, and double FUL1 FUL2 RNAi lines all show similar phenotypes supports the hypothesis that they may work as a tetramer to regulate ripening (Fujisawa et al 2014).…”

Section: Upstream Regulators and Interacting Partners Of Tagl1supporting

confidence: 56%

“…Other work using gel retardation assays indicate the likely existence of higher order complexes including RIN, TAGL1, FUL1, and FUL2 (Fujisawa et al 2014). The fact that the rin mutant, TAGL1 RNAi lines, and double FUL1 FUL2 RNAi lines all show similar phenotypes supports the hypothesis that they may work as a tetramer to regulate ripening (Fujisawa et al 2014). The key role that RIN plays in mediating tetramer formation is similar to the role SEP3 in Arabidopsis plays in tetramer formation as well (Favaro et al 2003;Fujisawa et al 2014).…”

Section: Upstream Regulators and Interacting Partners Of Tagl1supporting

confidence: 53%

“…Interaction studies and insights from other MADSbox genes in Arabidopsis indicate that TAGL1 functions as a transcriptional regulator, forming a heterodimer with RIN (similar to SEP in Arabidopsis) or in higher order tetramer complexes (Fujisawa et al 2014). Figure 3 shows a model of TAGL1 genetic interactions.…”

Section: An Integrated Model For Tagl1 Function In Various Ripening-rmentioning

confidence: 99%

“…3 Model of TAGL1 genetic interactions. This model was constructed using phenotypic data (loss or reduction of function and overexpression data), gene expression data, protein interaction data, promoter binding assays, and chromatin immunoprecipitation (Itkin et al 2009;Vrebalov et al 2009;Pan et al 2010;Pineda et al 2010;Gimenez et al 2010Gimenez et al , 2015Gimenez et al , 2016Martel et al 2011;Bemer et al 2012;Fujisawa et al 2014). The general function of the genes regulated by TAGL1 is noted in red.…”

Section: An Integrated Model For Tagl1 Function In Various Ripening-rmentioning

confidence: 99%

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Variations on a theme in fruit development: the PLE lineage of MADS-box genes in tomato (TAGL1) and other species

Garceau

Batson²,

Pan

2017

Planta

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Main conclusion This article focuses on the role of TOMATO AGAMOUS-LIKE 1 (TAGL1) on a wide range of ripening functions in tomato. We also examine orthologs of this gene in related species that produce different fruit types and discuss some evolutionary implications.TOMATO AGAMOUS-LIKE 1 (TAGL1) is a MADS-box transcription factor gene that belongs to the PLENA (PLE) lineage within the AGAMOUS (AG) clade. The most wellstudied genes in this lineage are the SHATTERPROOF (SHP) genes in Arabidopsis, known to be involved in dehiscence zone formation during silique development. In tomato, TAGL1 has been shown to control several aspects of tomato fruit ripening. Most notably, carotenoid synthesis seems to be controlled by TAGL1, likely via the ethylene synthesis and signaling pathway and in combination with RIPENING INHIBITOR (RIN). In addition, TAGL1 regulates genes involved in cell cycle regulation, flavonoid and lignin biosynthesis, and cuticle development. We discuss many of the genes in these different pathways that are likely controlled by TAGL1, directly or indirectly. We also examine the relationship of TAGL1 with known and putative interaction partners. PLE lineage genes have also been examined in other species such as Antirrhinum, Petunia, and Nicotiana and provide an interesting example of conservation and diversification of function in species that produce very different types of fleshy and dry fruits. The control of lignification may be a common mechanism for this group of genes. Lastly, we discuss future work needed to elucidate the TAGL1 regulatory pathway in tomato and to help better understand the functional diversification of genes in this lineage in related species.

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Section: Upstream Regulators and Interacting Partners Of Tagl1supporting

confidence: 56%

Section: Upstream Regulators and Interacting Partners Of Tagl1supporting

confidence: 53%

Section: An Integrated Model For Tagl1 Function In Various Ripening-rmentioning

confidence: 99%

Section: An Integrated Model For Tagl1 Function In Various Ripening-rmentioning

confidence: 99%

See 2 more Smart Citations

Variations on a theme in fruit development: the PLE lineage of MADS-box genes in tomato (TAGL1) and other species

Garceau

Batson²,

Pan

2017

Planta

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“…Among them are several MADS box genes: SlMADS-RIN of the SEPALLATA (SEP) E function clade (Vrebalov et al, 2002;Ito et al, 2008;Zhong et al, 2013); FRUIFULL (FUL1 and FUL2) homologs (Bemer et al, 2012;Shima et al, 2014); and TAGL1, an AGAMOUS (AG)-like MADS box gene necessary for both early fruit expansion and later ripening (Itkin et al, 2009;Vrebalov et al, 2009). The SlMADS-RIN protein interacts with additional MADS box proteins, including TAGL1 and SlTAGL11 (Leseberg et al, 2008) and the tomato FUL homologs FUL1 and FUL2, to execute ripening (Martel et al, 2011;Fujisawa et al, 2014). In one case, a member of the SEP clade, SlMADS1, has been suggested to act as a negative regulator (Dong et al, 2013).…”

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confidence: 99%

Banana MaMADS Transcription Factors Are Necessary for Fruit Ripening and Molecular Tools to Promote Shelf-Life and Food Security

et al. 2016

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Genetic solutions to postharvest crop loss can reduce cost and energy inputs while increasing food security, especially for banana (Musa acuminata), which is a significant component of worldwide food commerce. We have functionally characterized two banana E class (SEPALLATA3 [SEP3]) MADS box genes, MaMADS1 and MaMADS2, homologous to the tomato (Solanum lycopersicum) RIN-MADS ripening gene. Transgenic banana plants repressing either gene (via antisense or RNA interference [RNAi]) were created and exhibited specific ripening delay and extended shelf-life phenotypes, including delayed color development and softening. The delay in fruit ripening is associated with a delay in climacteric respiration and reduced synthesis of the ripening hormone ethylene; in the most severe repressed lines, no ethylene was produced and ripening was most delayed. Unlike tomato rin mutants, banana fruits of all transgenic repression lines responded to exogenous ethylene by ripening normally, likely due to incomplete transgene repression and/or compensation by other MADS box genes. Our results show that, although MADS box ripening gene necessity is conserved across diverse taxa (monocots to dicots), unlike tomato, banana ripening requires at least two necessary members of the SEPALLATA MADS box gene group, and either can serve as a target for ripening control. The utility of such genes as tools for ripening control is especially relevant in important parthenocarpic crops such as the vegetatively propagated and widely consumed Cavendish banana, where breeding options for trait improvement are severely limited.

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Improvement of Carotenoid Accumulation in Tomato Fruit

Shao

Zhang

et al. 2017

Phytonutritional Improvement of Crops

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Transcriptional Regulation of Fruit Ripening by Tomato FRUITFULL Homologs and Associated MADS Box Proteins

Cited by 193 publications

References 57 publications

Variations on a theme in fruit development: the PLE lineage of MADS-box genes in tomato (TAGL1) and other species

Variations on a theme in fruit development: the PLE lineage of MADS-box genes in tomato (TAGL1) and other species

Banana MaMADS Transcription Factors Are Necessary for Fruit Ripening and Molecular Tools to Promote Shelf-Life and Food Security

Improvement of Carotenoid Accumulation in Tomato Fruit

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