Transcriptomic responses of Artemia salina exposed to an environmentally relevant dose of Alexandrium minutum cells or Gonyautoxin2/3

Yi, Xiaoyan; Zhang, Keke; Liu, Lifen; Giesy, John P.; Li, Zhaochuan; Li, Wentao; Zhan, Jingjing; Liu, Lifen; Gong, Yufeng

doi:10.1016/j.chemosphere.2019.124661

Cited by 19 publications

(7 citation statements)

References 57 publications

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“…PSTs accumulation and shellfish contamination may be responsible for PSP outbreaks, thus leading to economic losses linked with fishery closures or recreational activities, and human intoxications. Moreover, PSTs have been associated with ichthyotoxicity [78,79], toxicity in shellfish [80], and deterrence or toxicity to copepods [81,82].…”

Section: Paralytic Shellfish Toxinsmentioning

confidence: 99%

“…chemically affects non-protistan grazers of the metazooplankton [65,179,180,212,213]. While available data suggest that protists are not affected by PSTs, the neurotoxins have demonstrated anti-grazing effects against non-protist grazers [81,82]. An anti-grazing activity of a PSTs standard mixture was shown on the marine copepod Tigriopus californicus [81], while toxic effects of purified gonyautoxin (analogues of STX) standards were evidenced on the crustacean Artemia salina [82].…”

Section: Anti-grazing Activitiesmentioning

confidence: 99%

“…While available data suggest that protists are not affected by PSTs, the neurotoxins have demonstrated anti-grazing effects against non-protist grazers [81,82]. An anti-grazing activity of a PSTs standard mixture was shown on the marine copepod Tigriopus californicus [81], while toxic effects of purified gonyautoxin (analogues of STX) standards were evidenced on the crustacean Artemia salina [82]. Another strong argument in favour of PST anti-grazing activity is drastic enhancement of PSTs production in the presence of some copepods or their chemical cues [197,[214][215][216].…”

Section: Anti-grazing Activitiesmentioning

confidence: 99%

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Unknown Extracellular and Bioactive Metabolites of the Genus Alexandrium: A Review of Overlooked Toxins

Long

Krock

Castrec

et al. 2021

Toxins

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Various species of Alexandrium can produce a number of bioactive compounds, e.g., paralytic shellfish toxins (PSTs), spirolides, gymnodimines, goniodomins, and also uncharacterised bioactive extracellular compounds (BECs). The latter metabolites are released into the environment and affect a large range of organisms (from protists to fishes and mammalian cell lines). These compounds mediate allelochemical interactions, have anti-grazing and anti-parasitic activities, and have a potentially strong structuring role for the dynamic of Alexandrium blooms. In many studies evaluating the effects of Alexandrium on marine organisms, only the classical toxins were reported and the involvement of BECs was not considered. A lack of information on the presence/absence of BECs in experimental strains is likely the cause of contrasting results in the literature that render impossible a distinction between PSTs and BECs effects. We review the knowledge on Alexandrium BEC, (i.e., producing species, target cells, physiological effects, detection methods and molecular candidates). Overall, we highlight the need to identify the nature of Alexandrium BECs and urge further research on the chemical interactions according to their ecological importance in the planktonic chemical warfare and due to their potential collateral damage to a wide range of organisms.

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Section: Paralytic Shellfish Toxinsmentioning

confidence: 99%

Section: Anti-grazing Activitiesmentioning

confidence: 99%

Section: Anti-grazing Activitiesmentioning

confidence: 99%

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Unknown Extracellular and Bioactive Metabolites of the Genus Alexandrium: A Review of Overlooked Toxins

Long

Krock

Castrec

et al. 2021

Toxins

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“…Thus far, few studies investigated the stress response of Artemia spp. through the evaluation of key genes involved in larval growth, molting, stress, and detoxification processes [32][33][34][35][36][37]. In this work, as well as evaluating PHE, NAP, FLT, and BkF acute (24 h-48 h-LC50) toxicity on nauplii and adults by measuring survival, we defined for the first time the molecular response of PAHs toxicity.…”

Section: Introductionmentioning

confidence: 99%

Genotoxicity Set Up in Artemia franciscana Nauplii and Adults Exposed to Phenanthrene, Naphthalene, Fluoranthene, and Benzo(k)fluoranthene

Albarano

Serafini

Toscanesi

et al. 2022

Water

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Polycyclic aromatic hydrocarbons (PAHs) consist of a group of over 100 different organic compounds mainly generated by anthropogenic activities. Because of their low water solubility, they tend to be accumulated in sediment, where their degradation rate is very low. Few studies have been carried out so far to investigate the effects of PAHs on Artemia franciscana. Artemia is easy to manage at laboratory scale, but it is not a sensitive biological model considering the traditional endpoints (i.e., mortality). In addition to evaluating the lethality on nauplii and adults of A. franciscana after 24 and 48 h, we focused on the genotoxicity to investigate the potential effects of phenanthrene (PHE), naphthalene (NAP), fluoranthene (FLT), and benzo(k)fluoranthene (BkF). Results showed that FLT was the most toxic both for nauplii and adults after 48 h of exposure. Real-time qPCR showed that all toxicants, including BkF, which had no negative effects on the survival of the crustacean, were able to switch the gene expression of all nine genes. This work has important ecological implications, especially on contaminated sediment assessment considering that PAHs represent the most abundant organic group of compounds in marine environment, opening new perspectives in understanding the molecular pathways activated by crustaceans.

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“…Hybridization has been demonstrated between LT and CR in nature through morphological structure analysis ( Xue et al, 2018 ) and molecular experiments ( Xue et al, 2020 ). High-throughput transcriptomic analysis, for example RNA-seq analysis based on Illumina sequencing technology, can help to identify potential biomarker genes and unravel underlying molecular mechanisms, and RNA-seq analysis needs no reference genome ( Shi Y. L. et al, 2019 ; Yi et al, 2020 ). Therefore, this study was designed to: (1) assess the effect of hybridization on the growth and tolerance of LT and CR under Cd stress; (2) explore the possible mechanisms by transcriptomics analysis of the leaves of LT, CR, X. sibiricum ♀ × X. strumarium ♂ (ZCR), and X. strumarium ♀ × X. sibiricum ♂ (ZLT).…”

Section: Introductionmentioning

confidence: 99%

Hybridization With an Invasive Plant of Xanthium strumarium Improves the Tolerance of Its Native Congener X. sibiricum to Cadmium

et al. 2021

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Hybridization is one of the important factors influencing the adaptive evolution of invasive plants. According to previous studies, hybridization with an invasive plant reduces the adaptability of its native congener to environment. However, in this study, the hybridization with an invasive plant of Xanthium strumarium (LT) improves the tolerance and accumulation of its native congener Xanthium sibiricum (CR) to cadmium (Cd). Under Cd stress, X. sibiricum♀ × X. strumarium♂ (ZCR) showed higher biomass and Cd accumulation. Compared with CR, ZCR has longer vegetative and reproductive growth time. Moreover, ZCR adopted more reasonable biomass allocation strategy. ZCR increased the proportion of reproductive allocation and ensured its own survival with the increase of Cd stress. Furthermore, ZCR increased the translocation of Cd to aboveground parts and changed the distribution of Cd. A large amount of Cd is stored in senescent leaves and eliminated from the plant when the leaves fall off, which not only reduces the Cd content in the plant, but also reduces the toxicity of Cd in the normal leaves. Transcriptome analysis shows a total of 2055 (1060 up and 995 down) differentially expressed genes (DEGs) were detected in the leaves of Cd-stressed ZCR compared with CR, while only 792 (521 up and 271 down) were detected in X. strumarium♀ × X. sibiricum♂ (ZLT) compared with LT. A large number of DGEs in ZCR and ZLT are involved in abscisic acid (ABA) synthesis and signal transduction. The genes induced by ABA in ZCR, including CNGC5/20, CPK1/28, CML, PTI1-like tyrosine-protein kinase 3, respiratory burst oxidase homolog protein C, and WRKY transcription factor 33 were found differentially expressed compared CR. carotenoid cleavage dioxygenase 4, NCED1/2, phytoene synthase 2, and CYP707A involved in ABA synthesis and decomposition in ZLT were found differentially expressed compared LT. We speculated that ABA played an important role in Cd transportation of hybrids and Cd distribution in senescent and normal leaves. The results demonstrate that hybridization with an invasive plant improves the adaptability of the hybrid to Cd stress and may enhance the extinction risk of native congener in pollution environment.

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Transcriptomic responses of Artemia salina exposed to an environmentally relevant dose of Alexandrium minutum cells or Gonyautoxin2/3

Cited by 19 publications

References 57 publications

Unknown Extracellular and Bioactive Metabolites of the Genus Alexandrium: A Review of Overlooked Toxins

Unknown Extracellular and Bioactive Metabolites of the Genus Alexandrium: A Review of Overlooked Toxins

Genotoxicity Set Up in Artemia franciscana Nauplii and Adults Exposed to Phenanthrene, Naphthalene, Fluoranthene, and Benzo(k)fluoranthene

Hybridization With an Invasive Plant of Xanthium strumarium Improves the Tolerance of Its Native Congener X. sibiricum to Cadmium

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