Transdermal Diagnosis of Malaria Using Vapor Nanobubbles

Lukianova‐Hleb, Ekaterina Y.; Bezek, Sarah; Szigeti, Réka; Khodarev, Alexander; Kelley, Thomas A.; Hurrell, Andrew; Berba, M; Kumar, Nirbhay; D’Alessandro, Umberto; Lapotko, Dmitri O.

doi:10.3201/eid2107.150089

Cited by 28 publications

(30 citation statements)

References 31 publications

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“…35 To date, the results of this approach have only been reported in a single patient and questions have been raised about the study method, in terms of the reliability of the diagnosis and the rationale for failing to determine parasitemia at the time of the device test rather than hours before and after. 36 …”

Section: Five-year Viewmentioning

confidence: 99%

Hemozoin detection may provide an inexpensive, sensitive, 1-minute malaria test that could revolutionize malaria screening

Grimberg

2016

Expert Review of Anti-infective Therapy

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Malaria remains widespread throughout the tropics and is a burden to the estimated 3.5 billion people who are exposed annually. The lack of a fast and accurate diagnostic method contributes to preventable malaria deaths and its continued transmission. In many areas diagnosis is made solely based on clinical presentation. Current methods for malaria diagnosis take more than 20 minutes from the time blood is drawn and are frequently inaccurate. The introduction of an accurate malaria diagnostic that can provide a result in less than 1 minute would allow for widespread screening and treatment of endemic populations, and enable regions that have gained a foothold against malaria to prevent its return. Using malaria parasites’ waste product, hemozoin, as a biomarker for the presence of malaria could be the tool needed to develop this rapid test.

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Section: Five-year Viewmentioning

confidence: 99%

Hemozoin detection may provide an inexpensive, sensitive, 1-minute malaria test that could revolutionize malaria screening

Grimberg

2016

Expert Review of Anti-infective Therapy

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“…The main objection comes to our alleged call for “large-scale studies in humans”; no such statement appeared in our 2014 article ( 2 ), and in the 2015 article ( 3 ), we clearly stated that large-scale studies will be considered after the optimization of a new prototype and improving its sensitivity. The authors’ final questioning of our eligibility for resources is a nonscientific opinion.…”

mentioning

confidence: 83%

“…In Response: The letter by Rebelo et al ( 1 ) that questions our previously described noninvasive malaria diagnostics ( 2 , 3 ) misinterprets both articles. The main objection comes to our alleged call for “large-scale studies in humans”; no such statement appeared in our 2014 article ( 2 ), and in the 2015 article ( 3 ), we clearly stated that large-scale studies will be considered after the optimization of a new prototype and improving its sensitivity.…”

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confidence: 97%

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Transdermal Diagnosis of Malaria Using Vapor Nanobubbles

Lukianova‐Hleb¹,

Bezek²,

Szigeti³

et al. 2016

Emerg. Infect. Dis.

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“…Several novel platforms such as magneto-optical detection, magnetic resonance relaxometry and biosensing [36][37][38] have been explored to detect the hemozoin pigment in Plasmodium genus infections. Transdermal laser detection of hemozoingenerated vapor nanobubbles has also been reported recently [39]. However, at present, the platforms for detection of hemozoin are still being optimized and there are still a lot of unknowns with regard to the diagnostic and performance characteristics as well as cost.…”

Section: Non-nucleic Acid Amplification Testmentioning

confidence: 98%

Novel techniques and future directions in molecular diagnosis of malaria in resource-limited settings

Oriero

Geertruyden

Nwakanma

et al. 2015

Expert Review of Molecular Diagnostics

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Despite being preventable and treatable, malaria remains a global health concern with approximately 1.2 billion people at high risk of being infected, 90% of whom are in the resource-limited settings of sub-Saharan Africa. The continued decline in malaria cases globally has rekindled the possibility of elimination in certain regions. As humans constitute the main reservoir of malaria, prompt and accurate diagnosis by microscopy or rapid diagnostic tests is part not only of effective disease management but also of control measures. However, for malaria elimination, more sensitive diagnostic tools are needed to detect asymptomatic and sub-microscopic infections that contribute to transmission. Molecular techniques, which involve amplification of nucleic acids, are being developed and modified to suit this purpose. This report provides a summary of the nucleic acid amplification tests that are currently available for diagnosis of malaria, with current improvements and adaptations for use in resource-limited settings.

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Transdermal Diagnosis of Malaria Using Vapor Nanobubbles

Abstract: Our laser device rapidly and noninvasively detected malaria in a patient and identified parasite-positive mosquitoes.

Cited by 28 publications

References 31 publications

Hemozoin detection may provide an inexpensive, sensitive, 1-minute malaria test that could revolutionize malaria screening

Hemozoin detection may provide an inexpensive, sensitive, 1-minute malaria test that could revolutionize malaria screening

Transdermal Diagnosis of Malaria Using Vapor Nanobubbles

Novel techniques and future directions in molecular diagnosis of malaria in resource-limited settings

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