Transdermal Iontophoretic Delivery of Propofol: A General Anaesthetic in the Form of its Phosphate Salt

Juluri, Abhishek; Peddikotla, Prabhakar; Repka, Michael A.; Murthy, S. Narasimha

doi:10.1002/jps.23373

Cited by 19 publications

(12 citation statements)

References 35 publications

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“…Due to increased solubility as well as direct action on the stratum corneum, HP-β-CD/DM-β-CD-celecoxib complexes demonstrated an enhanced percutaneous absorption (Ventura et al, 2006). Attempt was also made to enhance the transdermal delivery from propofol-CD complex by iontophoresis, a physical enhancement technique (Juluri, Peddikotla, Repka, & Murthy, 2013). The prospective of drug-CD in enhancing the transungual delivery of terbinafine was also demonstrated (Chouhan & Saini, 2014;Nair, Sammeta, Vaka, & Murthy, 2009).…”

Section: Transdermal Deliverymentioning

confidence: 99%

Cyclodextrin complexes: Perspective from drug delivery and formulation

Jacob

Nair

2018

Drug Development Research

174

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Cyclodextrins (CDs) have been widely investigated as a unique pharmaceutical excipient for past few decades and is still explored for new applications. They are highly versatile oligosaccharides which possess multifunctional characteristics, and are mainly used to improve the physicochemical stability, solubility, dissolution rate, and bioavailability of drugs. Stability constant, factors affecting complexation, techniques to enhance complexation efficiency, the preparation methods for molecular inclusion complexes and release of guest molecules are discussed in brief. In addition, different CD derivatives and their pharmacokinetics are elaborated. Further, the significance of CD complex in aqueous solubility, dissolution and bioavailability, stability, and taste masking is explained. The recent advancement of CDs in developing various drug delivery systems is enlightened. Indeed, the potential of CDs by means of inclusion complex formation have widen the applicability of these materials in various drug delivery systems including ocular, osmotic, mucoadhesive, transdermal, nasal, and targeted delivery systems. Feasibility studies have been performed on the benefit of these cyclic oligomers as nanocarriers, a strategy that can modify the drugs with improved physicochemical properties. Studies also demonstrated the feasibility of CDs to self-assemble in the form of stable nanoaggregates, which may extend the scope of CDs in drug delivery to the continually expanding list of new drug entities.

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Section: Transdermal Deliverymentioning

confidence: 99%

Cyclodextrin complexes: Perspective from drug delivery and formulation

Jacob

Nair

2018

Drug Development Research

174

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“…Use of nanoparticles, mucoadhesive agents, absorption enhancers, surfactants, lipid emulsions, vasoconstrictors and efflux transporter inhibitors are some of the potential approaches to reduce the clearance and enhance the residence time [29][30][31][32][33][34][35][36][37].…”

Section: Nanoparticular Delivery Systemmentioning

confidence: 99%

Recent Updates in the Formulation Strategies to Enhance the Bioavailability of Drugs Administered via Intranasal Route

Dudhipala¹,

Narala²,

Bomma³

2016

J Bioequiv Availab

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“…Propofol is an anesthetic, widely used to induce sedation, predictable amnesia and anxiolysis. Propofol is clinically recommended due to its rapid onset of action with minimum side effects [1]. It is highly used in pediatric population, as it is safe and efficacious.…”

Section: Introductionmentioning

confidence: 99%

“…It is a slightly yellow oily liquid with lipophilic in nature. Propofol is available in the form of injectable emulsion that contains lipid ingredients such as soybean oil and egg phosphatide [1,3].…”

Section: Introductionmentioning

confidence: 99%

A Screening of Permeation Enhancers for Transdermal Delivery of Propofol

Kushwaha¹

2018

J Bioequiv Availab

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Propofol is a highly lipophilic anesthetic drug used to induce sedation, predictable amnesia and anxiolysis. In this project, several permeation enhancers were screened to improve the permeation of propofol across the porcine full thickness skin. The screening studies of permeation enhancers was performed in two phases. As a result of the first phase of screening studies, DMSO, Laureth-4 and transcutol were found to be the potential penetration enhancers which improved the permeation of propofol across the skin ~ 4, 3.5 and 4.5-fold more compared to control. A 100% propofol was used as a control. In the second phase, the combination of DMSO and Laureth-L4 (F1) delivered 278.6 ± 20.3 µg/cm 2 propofol across the skin which were found to be ~ 18 more compared to control (15.68 ± 2.6 µg/cm 2). The studies in this project concluded that the combination of DMSO and Laureth-L4 can be used for the development of transdermal propofol product in the future.

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Transdermal Iontophoretic Delivery of Propofol: A General Anaesthetic in the Form of its Phosphate Salt

Cited by 19 publications

References 35 publications

Cyclodextrin complexes: Perspective from drug delivery and formulation

Cyclodextrin complexes: Perspective from drug delivery and formulation

Recent Updates in the Formulation Strategies to Enhance the Bioavailability of Drugs Administered via Intranasal Route

A Screening of Permeation Enhancers for Transdermal Delivery of Propofol

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