Transdermal Iontophoretic Delivery of Thyrotropin-Releasing Hormone Across Excised Rabbit Pinna Skin

Huang, Yi‐You; Wu, Shian-Min

doi:10.3109/03639049609065943

Cited by 7 publications

(9 citation statements)

References 8 publications

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“…8) Conversely, Huang and Wu suggested that the absorption was greater by PDC (0.64 mA/cm 2 , rectangular waveform, 3 kHz and 50% duty cycle) than DC (0.32 mA/cm 2 ) using thyrotropin-releasing hormone (TRH). 9) A similar tendency was reported by Knoblauch and Moll using buserelin between PDC (0.1-0.2 mA/cm 2 , rectangular waveform, 2 kHz and 50% duty cycle) and DC (0.1 mA/cm 2 ). 10) As mentioned above, the absorption of drug by DC and PDC iontophoresis has differed with investigators.…”

supporting

confidence: 58%

Evaluation of Skin Barrier Function Using Direct Current II: Effects of Duty Cycle, Waveform, Frequency and Mode.

Kanebako¹,

Inagi²,

Takayama

2002

Biological & Pharmaceutical Bulletin

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The aim of this study was to evaluate the reduction in skin barrier function caused by pulsed iontophoresis by measuring resistance in the short term. Experiments under direct current (DC) and pulsed direct current (PDC) conditions were carried out using rat abdominal skin in vivo. The resistance was measured every 62.5 m ms and analyzed using a two-compartment model consisting of surface and skin resistance. Moreover, the initial value and the rate constant of surface resistance were calculated with the non-linear approximation program. Using this method, effects of duty cycle, waveform, frequency and mode on the skin barrier function were examined. The barrier function decreased with increasing duty cycle. With regard to waveforms, the influence on the skin barrier function was greatest in the order of sine, rectangular, saw and triangular waveforms. A frequency of less than 100 Hz reduced the barrier function. Considering the reduction in barrier function and skin polarization, the PDC of a rectangular waveform (around 75% as duty cycle and less than 100 Hz as frequency) or sine waveform was most suitable. In addition, the difference in the amount of drug delivered by DC and by PDC was discussed.

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supporting

confidence: 58%

Evaluation of Skin Barrier Function Using Direct Current II: Effects of Duty Cycle, Waveform, Frequency and Mode.

Kanebako¹,

Inagi²,

Takayama

2002

Biological & Pharmaceutical Bulletin

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“…For angiotensin II and its antagonists, undetectable amounts of drug are transported across excised skin during passive diffusion (without facilitated by an external electrical field). In our early study, the smaller peptide, TRH (MW.=362), also didn't show any detectable amounts of drug permeated through excised skin during passive diffusion [2]. While during iontophoresis, under the monophase periodically pulsed current with the frequency of current: 1000Hz, duty cycle 50%, offset 1mA, and the mean current 1 mA, the permeation Vol.…”

Section: Resultsmentioning

confidence: 76%

“…Clemessy et al, [61 found that under the current density of 0.28 mA/cm , the angiotensin II transport was be enhanced 20-fold in comparison to passive permeation. The enhancement of permeation of peptide drugs by iontophoresis was proportional to the current density [2,6,7]. But the real mechanism of transport is still not clear even ambiguous [5,8].…”

Section: Biomedical Engineering-applications Basis and Communicationsmentioning

confidence: 99%

“…In our early study, we had investigated the possibility of transdermal iontophoretic delivery of the smaller peptide, TRH (M.W.=362) [2]. Though there wasn't any detectable amounts of drug being permeated through excised skin during passive diffusion, the permeation amount of TRH increased with respect to time when an electrical field was applied.…”

Section: Biomedical Engineering-applications Basis and Communicationsmentioning

confidence: 99%

“…lontophoretic transdermal delivery is a noninvasive method which minimizes trauma, risk of infection, and damage to the skin. When a drug is administered by topical iontophoresis, the drug bypasses the digestive tract and escapes first-pass metabolism in the liver (1,2]. Effective use of iontophoresis depends upon the chemical properties of the drug.…”

Section: Introductionmentioning

confidence: 99%

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Iontophoretic Transdermal Delivery of Angiotensin Ii and Its Antagonists

Huang

2001

Biomed. Eng. Appl. Basis Commun.

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Angiotensin II and its antagonists were used as permeant probes to investigate the mechanism of transdermal iontophoretic delivery of peptide/protein drugs and compare the effect of hydrophobic difference between the peptides drugs on the skin permeability. Transport of angiotensin II and its antagonists through excised rabbit pinna skin were enhanced with iontophoresis by monophase periodically pulsed current, amplituide=1mA, frequency=1000Hz and on/off ratio equals 50%. The delivery rate was proportional both to the current intensity and pulse duration of the stimulation. Results showed that the permeation rate of [Sar, Ile] Angiotensin II > [Sar,Ala]Angiotensin II > Angiotensin II. Iontophoretic mobility and hydrophobicity were the key factors dominating the transdermal iontophoretic delivery rate of angiotensin II and its antagonists.

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Intestinal iontophoresis from mucoadhesive patches: a strategy for oral delivery

Banerjee

Chen

Arafin

et al. 2019

Journal of Controlled Release

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Transdermal Iontophoretic Delivery of Thyrotropin-Releasing Hormone Across Excised Rabbit Pinna Skin

Cited by 7 publications

References 8 publications

Evaluation of Skin Barrier Function Using Direct Current II: Effects of Duty Cycle, Waveform, Frequency and Mode.

Evaluation of Skin Barrier Function Using Direct Current II: Effects of Duty Cycle, Waveform, Frequency and Mode.

Iontophoretic Transdermal Delivery of Angiotensin Ii and Its Antagonists

Intestinal iontophoresis from mucoadhesive patches: a strategy for oral delivery

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