Transferrin and transferrin receptor gene expression and iron uptake in hepatocellular carcinoma in the rat

Pascale, Rosa M.; Miglio, Maria Rosaria De; Muroni, Maria Rosaria; Simile, Maria M.; Daino, Lucia; Seddaiu, Maria A.; Pusceddu, Stefano; Gaspa, Leonardo; Calvisi, Diego F.; Manenti, Giacomo; Feo, Francesco

doi:10.1002/hep.510270220

Cited by 22 publications

(17 citation statements)

References 44 publications

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“…patients (6) . The present study showed an increase in the serum levels or positive correlation with CTP or BCLC in transferrin (in CI group), iron (in CI and HCC group) and ferritin saturation (in HCC group), which is in accordance with the literature (11,28,30,38) . A possible explanation is the fact that the iron absorbance through transferrin receptors is higher in hepatocellular carcinoma than in a normal liver, making the transferrin a marker of the presence of HCC (28) .…”

Section: Discussionsupporting

confidence: 93%

“…Some (11,28,30,38) affirm that there are increases in serum transferrin, iron and ferritin saturation levels, positively correlated with the presence of HCV, cirrhosis and HCC, especially in more advanced stages of the diseases. However, other authors have not observed alterations in the iron levels (4) or report reduction in liver cirrhosis and HCC Port GZ, Oliveira K, Soldera J, Tovo CV.…”

Section: Discussionmentioning

confidence: 95%

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Biochemical Nutritional Profile of Liver Cirrhosis Patients With Hepatocellular Carcinoma

Port

Oliveira

Soldera

et al. 2014

Arq. Gastroenterol.

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-Context -Liver cirrhosis patients with hepatocellular carcinoma present nutritional alterations and metabolic disorders that negatively impact the prognosis. Objective -The objective is to identify alterations in the metabolism of macro and micronutrients among liver cirrhosis patients with and without hepatocellular carcinoma and their relation to the Child-Turcote-Pugh score and Barcelona Clinic Liver Cancer staging. Methods -Analytical transversal study, with 31 hepatocellular carcinoma patients and 48 liver cirrhosis patients. Laboratorial exams were carried out. The existence of an association between the biochemical parameters and the disease severity as well as the presence of hepatocellular carcinoma was assessed. Results -The metabolic-nutritional profile of liver cirrhosis patients caused by the hepatitis C virus and hepatocellular carcinoma showed alterations, specifically the lipid (total cholesterol, HDL and triglycerides), protein (albumin, creatinine and uric acid), iron (transferrin, iron and ferritin saturation), hematocrit and hemoglobin, zinc and B12 vitamin profiles. There is a relation between nutritional biochemical markers and the Child-Turcote-Pugh, as well as Barcelona Clinic Liver Cancer staging. Conclusion -Considering the existence of alterations in the metabolism of nutrients in liver cirrhosis patients with and without hepatocellular carcinoma, and also that conventional nutritional assessment methods present limitations for this population, the biochemical laboratorial exams are valid to complement the diagnosis of the nutritional state in a quick and practical manner.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 95%

Biochemical Nutritional Profile of Liver Cirrhosis Patients With Hepatocellular Carcinoma

Port

Oliveira

Soldera

et al. 2014

Arq. Gastroenterol.

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“…Transferrin receptors are increased in HCC when compared to normal livers [88] and the surrounding noncancerous tissues [89] suggesting that the iron content in HCC might be higher than in normal livers and surrounding noncancerous tissues. The majority of the studies included in this review have shown lower iron content HCC compared to normal livers and surrounding noncancerous tissues.…”

Section: Discussionmentioning

confidence: 99%

Trace Element Concentration in Primary Liver Cancers—A Systematic Review

Gurusamy

2007

Biol Trace Elem Res

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“…However, in experimental studies TFR gene expression has been shown to be increased in preneoplastic nodules and in HCC [18]. …”

Section: Introductionmentioning

confidence: 99%

Interaction between Haemochromatosis and Transferrin Receptor Genes in Hepatocellular Carcinoma

Beckman

Hägerstrand²,

Stenling³

et al. 2000

Oncology

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In hepatocellular carcinoma (HCC) iron has been implicated as a risk factor primarily in patients with hereditary haemochromatosis (HH) and cirrhosis. The wild-type HH (HFE) protein complexes with the transferrin receptor (TFR), and two HFE mutations (Cys282Tyr and His63Asp) have been found to increase the affinity of the TFR for transferrin resulting in an increased cellular uptake of iron. In previous studies we found an interaction between HFE and TFR genotypes in multiple myeloma and breast and colorectal carcinomas. In the present investigation we have studied HFE and TFR genotypes in 54 Swedish patients with HCC, using DNA from archival samples of paraffin wax blocks. The same HFE-TFR interaction as in the previously studied neoplastic disorders was found. Individuals carrying the HFE282Tyr allele (homo- and heterozygotes) in combination with homozygosity for the TFR Ser allele showed an increased risk for HCC (OR = 3.5; 95% confidence interval, CI = 1.3–9.3), which was further increased in HFE Tyr homozygotes and compound (Tyr/Asp) heterozygotes in combination with TFR 142Ser homozygosity (OR = 17.2; 95% CI = 1.8–168.9). The presence of liver cirrhosis could only be assessed in part of the patient material. In patients with verified liver cirrhosis the risk figures were substantially increased: for HFE 282 Tyr carriers in combination with TFR 142Ser/Ser OR = 7.2; 95% CI = 2.0–25.5 and for HFE 282Tyr homozygotes and compound heterozygotes in combination with TFR 142Ser homozygosity, OR = 62.8; 95% CI = 6.1–642.5.

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Transferrin and transferrin receptor gene expression and iron uptake in hepatocellular carcinoma in the rat

Cited by 22 publications

References 44 publications

Biochemical Nutritional Profile of Liver Cirrhosis Patients With Hepatocellular Carcinoma

Biochemical Nutritional Profile of Liver Cirrhosis Patients With Hepatocellular Carcinoma

Trace Element Concentration in Primary Liver Cancers—A Systematic Review

Interaction between Haemochromatosis and Transferrin Receptor Genes in Hepatocellular Carcinoma

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