Transfusion-associated Graft-versus-Host Disease (TA-GVHD): Cellular mechanisms and their possible modulation by ultraviolet radiation

Andreu, G.; P, Fressy

doi:10.1016/0955-3886(95)97393-e

Transfusion Science

1995

DOI: 10.1016/0955-3886(95)97393-e

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Transfusion-associated Graft-versus-Host Disease (TA-GVHD): Cellular mechanisms and their possible modulation by ultraviolet radiation

G. Andreu

Fressy P

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Cited by 3 publications

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“…Passenger T cells, normally present in cellular blood components, provide no therapeutic benefits to recipients and may be responsible for a number of adverse transfusion effects, including transfusion‐associated GVHD (TA‐GVHD), 1–3 transmission of cell‐associated viruses, 4 and activation of latent HIV 5,6 …”

mentioning

confidence: 99%

Assessment of donor T‐cell function in cellular blood components by the CD69 induction assay: effects of storage, γ radiation, and photochemical treatment

et al. 2000

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mentioning

confidence: 99%

Assessment of donor T‐cell function in cellular blood components by the CD69 induction assay: effects of storage, γ radiation, and photochemical treatment

et al. 2000

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Reduced alloimmunization in mice following repeated transfusion with pathogen‐reduced platelets

et al. 2016

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Reduced MHC alloimmunization and partial tolerance protection with pathogen reduction of whole blood

et al. 2016

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BACKGROUND Allogeneic blood transfusion can result in an immune response against major histocompatibility complex (MHC) antigens, potentially complicating future transfusions or transplants. We have previously shown that pathogen reduction of platelet-rich plasma (PRP) with riboflavin and UV light (UV+R) can prevent alloimmunization in mice. A similar pathogen reduction treatment is currently under development for the treatment of whole blood using riboflavin and a higher dose of UV light. We sought to determine the effectiveness of this treatment in prevention of alloimmunization. STUDY DESIGN AND METHODS BALB/c mice were transfused with untreated or UV+R treated allogeneic C57Bl/6 whole blood with or without leukoreduction. Mice were evaluated for donor specific antibodies and ex vivo splenocyte cytokine responses, as well as for changes in the frequency of regulatory T (Treg) cells. RESULTS UV+R treatment blocked cytokine priming and reduced anti-MHC alloantibody responses to transfused whole blood. Leukoreduction reduced alloantibody levels in both the untreated and UV+R groups. Mice transfused with UV+R treated whole blood had reduced alloantibody and cytokine responses when subsequently transfused with untreated blood from the same donor type. This reduction in responses was not associated with increased Treg cells. CONCLUSIONS Pathogen reduction of whole blood with UV+R significantly reduces, but does not eliminate the alloimmune response. Exposure to UV+R treated whole blood transfusion does appear to induce tolerance to alloantigens resulting in reduced anti-MHC alloantibody and cytokine responses to subsequent exposures to the same alloantigens. This tolerance does not appear to be driven by an increase in Treg cells.

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Transfusion-associated Graft-versus-Host Disease (TA-GVHD): Cellular mechanisms and their possible modulation by ultraviolet radiation

Cited by 3 publications

References 14 publications

Assessment of donor T‐cell function in cellular blood components by the CD69 induction assay: effects of storage, γ radiation, and photochemical treatment

Assessment of donor T‐cell function in cellular blood components by the CD69 induction assay: effects of storage, γ radiation, and photochemical treatment

Reduced alloimmunization in mice following repeated transfusion with pathogen‐reduced platelets

Reduced MHC alloimmunization and partial tolerance protection with pathogen reduction of whole blood

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