Transfusion of Plasma Products

Brooks, Marjory B.

doi:10.1002/9781119500537.ch100

Cited by 2 publications

(5 citation statements)

References 21 publications

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“…29,30 Veterinary textbooks recommend initial doses ranging from 6 to 20 ml/kg, without specifying the species. 3,31 In a recent retrospective feline study, the FFP doses commonly used (mean 6 ml/kg) were lower than those reported for coagulopathy in dogs and humans. 4 Only 33% of the recipients were bleeding at the time of transfusion in this feline study, so most of the transfusions were performed with a prophylactic goal.…”

Section: Discussionmentioning

confidence: 94%

“…5 Current veterinary convention is that FFP is termed frozen plasma (FP) when it exceeds the recommended 1-year storage time, and it is theoretically characterised by a reduced content of labile coagulation factors. 2,3,6 Quality control of human FFP is based on the measurement of coagulation factors V and VIII, which are considered the most labile. 2,7 A canine plasma study conducted in 2013 demonstrated that 5-year-old FP is haemostatically active, with a significant decrease in factor VIII activity but with a sustained stability of factor V, indicating that differences within species might exist.…”

Section: Introductionmentioning

confidence: 99%

“…Using plasma products rather than whole blood allows for longer storage times, increased availability and lower costs, and minimises the risk of transfusion reactions. 2,3 The most common reason for the administration of feline FFP (fFFP) is for haemostatic purposes, and FFP transfusion is the gold standard of care in patients with coagulopathies. 3,4 In a 2020 study by Lane and Sinnott-Stutzman, 4 the most common indications for fFFP were suspected coagulopathy, haemorrhage and hypotension.…”

Section: Introductionmentioning

confidence: 99%

“…2,3 The most common reason for the administration of feline FFP (fFFP) is for haemostatic purposes, and FFP transfusion is the gold standard of care in patients with coagulopathies. 3,4 In a 2020 study by Lane and Sinnott-Stutzman, 4 the most common indications for fFFP were suspected coagulopathy, haemorrhage and hypotension.…”

Section: Introductionmentioning

confidence: 99%

“…8 Recommended storage times for feline plasma have been adapted from human medicine, where many authors consider that plasma can be only classified as FFP within 1 year of storage based on the loss of factors V and VIII. 3 However, to our knowledge, there have been no studies evaluating the stability of feline haemostatic proteins in plasma during storage.…”

Section: Introductionmentioning

confidence: 99%

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Stability of coagulation factors in feline fresh frozen plasma intended for transfusion after 1 year of storage

Blasi-Brugué

Ferreira

Sánchez

et al. 2022

Journal of Feline Medicine and Surgery

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Objectives The most common use of plasma transfusion is for haemostatic purposes, but coagulation factor activities in stored feline plasma are unknown. The concentration and stability of coagulation factors I (fibrinogen), II, V, VII, VIII, IX, X, XI and XII in feline fresh frozen plasma (fFFP) stored for 1 year were studied. Methods Fifty-five units of fFFP were produced from 55 fresh whole-blood donations obtained from indoor healthy blood donor cats. Twenty-one units were stored for <2 weeks (T0) and 34 were stored for 1 year (T1). After the completion of storage, specific coagulation factor activities for factors II, V, VII, VIII, IX, X, XI and XII were tested using modified one-stage activated partial thromboplastin or prothrombin time assays. Fibrinogen was determined using the Clauss method. Results Significantly decreased activities were observed for factors II (T0: 101.94% ± 19.06%; T1: 73.23% ± 39.06% [ P = 0.001]), VII (T0: 102.78% ± 24.69%; T1: 60.08% ± 38.17% [ P <0.001]), VIII (T0: 77.52% ± 30.39%; T1: 50.32% ± 23.8% [ P = 0.001]), XI (T0: 88.76% ± 22.73%; T1: 66.28% ± 22.2% [ P = 0.001]) and XII (T0: 89.50% ± 21.85%; T1: 55.46% ± 23.18% [ P <0.001]) when comparing units at time 0 and after 1 year of storage. No significant difference was observed for factors IX (T0: 84.86% ± 29.35%; T1: 71.37% ± 22.23% [ P = 0.064]) and X (T0: 96.24% ± 25.1%; T1: 83.91% ± 49.54% [ P = 0.236]). Unexpectedly, a significant increase was observed for factor V (T0: 71.94% ± 24.14%; T1: 97.89% ± 62.33%; P = 0.046). Fibrinogen was 2.76 ± 1.09 g/l at T1. Factors VIII, XII and VII had the lowest mean activities after 1 year. Conclusions and relevance Although a decrease in most coagulation factors activities was noted with storage, 1-year-old fFFP was haemostatically active in vitro. The most suitable factors for quality control assessment of fFFP are factors VII and VIII. Approximately 13–20 ml/kg of fFFP is required to administer a minimum of 10 IU/kg coagulation factor activity.

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Section: Discussionmentioning

confidence: 94%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Stability of coagulation factors in feline fresh frozen plasma intended for transfusion after 1 year of storage

Blasi-Brugué

Ferreira

Sánchez

et al. 2022

Journal of Feline Medicine and Surgery

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Post transfusion reactions in animals (review)

Nekrasova

Andreeva

Lunegov

et al. 2023

jour

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Currently, veterinary specialists are increasingly using blood transfusion in various pathological conditions of the animal body. But at the same time, the effect of hemoconservatives on the body of animals and whole blood has been little studied. The review article provides an analysis of the results of studies of post-transfusion complications in the period from 2008 to 2022. Particular attention in these studies was paid to the frequency of occurrence, the quality of blood or its component, the compatibility of the donor and recipient, complications during and after hemotransfusion. Post-transfusion reactions that can occur as a result of blood transfusion have shown a number of possible immunological and nonimmunological reactions of the organism of animals and humans, the origin of which has been little studied. Posttransfusion reactions of the body include incompatibility reactions, reactions to erythrocyte proteins, reactions to platelets and leukocytes during plasma transfusion, anaphylactoid reactions, hypothermia, heparinization, coagulopathy and thrombosis, microbial contamination, hyperammonemia, hypophosphatemia, hyperkalemia, acidosis, pre-transfusion hemolysis, hemosiderosis. The frequency of occurrence of these reactions has not been sufficiently studied, since mainly isolated cases or studies with a small sample are described. The problem of post-transfusion reactions in animals in our country began to be studied recently. Post-transfusion reactions are practically not monitored, since this requires additional research in a hospital veterinary clinic.

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Transfusion of Plasma Products

Cited by 2 publications

References 21 publications

Stability of coagulation factors in feline fresh frozen plasma intended for transfusion after 1 year of storage

Stability of coagulation factors in feline fresh frozen plasma intended for transfusion after 1 year of storage

Post transfusion reactions in animals (review)

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