Transhiatal distal esophagectomy for Siewert type II cardia cancer can be a treatment option in selected patients

Reddavid, Rossella; Strignano, Paolo; Sofia, Silvia; Evangelista, Andrea; Deiro, Giacomo; Cannata, G; Chiaro, Paolo; Maiello, Fabio; Mineccia, Michela; Ferrero, Alessandro; Leli, R; Gentilli, Sergio; Polastri, Roberto; Borghi, Felice; Camandona, Michele; Romagnoli, Renato; Morino, Mario; Degiuli, Maurizio

doi:10.1016/j.ejso.2019.04.001

Cited by 12 publications

(26 citation statements)

References 24 publications

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“…Ninetysix articles were retrieved for full-text assessment and 85 articles were excluded due to reasons such as not having sufficient data on Siewert type Ⅱ AEG. Ultimately, 11 articles were included in the meta-analysis [19,21,23,24,[31][32][33][34][35][36][37], and the characteristics of these studies are shown in Table 2.…”

Section: Study Selection and Characteristicsmentioning

confidence: 99%

“…Perioperative mortality rate (%): Seven studies [23,24,31,32,34,36,37] showed no significant difference in perioperative mortality rate between the two surgical approaches (OR = 0.86; 95%CI: 0.43, 1.71; P = 0.67) (Figure 4).…”

Section: Perioperative Outcomesmentioning

confidence: 99%

“…A significant increase in the incidence of pulmonary complications was observed following the TT approach compared with the TH approach. The random-effects model was used due to heterogeneity between these seven studies [23,24,31,32,34,35,37] (Tau2 = 0.15; Chi2 = 9.19, df = 6, P = 0.16, I2 = 35%) (OR = 0.44; 95%CI: 0.27, 0.73; P < 0.01).…”

Section: Pulmonary Complication Rate (%)mentioning

confidence: 99%

“…Abdominal complication rate (%): Using the random-effects model, five articles [23,24,32,34,37] reported no significant difference in the rate of abdominal complications between the TH and TT approaches (Tau2 = 1.22; Chi2 = 11.73, df = 4, P = 0.02, I2 = 66%) (OR = 2.20; 95%CI: 0.63, 7.67; P = 0.22).…”

Section: Pulmonary Complication Rate (%)mentioning

confidence: 99%

“…There is debate as to which approach can reduce perioperative morbidity and improve long-term survival more effectively following radical resection (R0) with adequate lymph node dissection. The TT approach can ensure sufficient distance of the proximal margin and adequate resection of mediastinal lymph nodes under direct visualization [23,24]. However, pulmonary complications such as pneumothorax are often observed [25].…”

Section: Introductionmentioning

confidence: 99%

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Transhiatal versus transthoracic surgical approach for Siewert type Ⅱ adenocarcinoma of the esophagogastric junction: a meta-analysis

Shang

et al. 2020

Expert Review of Gastroenterology & Hepatology

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Background: With the increasing prevalence of Siewert type Ⅱ adenocarcinoma of the esophagogastric junction (EGJ), the optimal surgical treatment is not universally agreed. This meta-analysis compares the safety and efficacy between the transhiahtal (TH) approach and the transthoracic (TT) approach. Methods: A systematic and electronic search of several databases was performed up to June 2020. The Newcastle-Ottawa scale was used to evaluate article quality and funnel plots were created to identify potential publication bias. The random-effects model was used when significant heterogeneity was identified. Results: In total, nine retrospective studies and two randomized controlled trials (RCTs) involving 2331 patients were included. Decreased intraoperative blood loss, shorter hospital stay, lower incidence of pulmonary complications, and longer 3-year overall survival were observed in the TH group. There were no significant differences concerning duration of surgery, R0 resection rate, number of dissected lymph nodes, perioperative mortality and morbidity rate, abdominal complication rate, or anastomotic leak rate. With regard to 5-year overall survival, a potential benefit may be achieved with the TH approach, which requires further confirmation. Conclusion: In terms of surgery-related and long-term outcomes, the TH approach may be more appropriate for Siewert type Ⅱ adenocarcinoma of EGJ, especially for esophagus invasion ≤4 cm.

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Section: Study Selection and Characteristicsmentioning

confidence: 99%

Section: Perioperative Outcomesmentioning

confidence: 99%

Section: Pulmonary Complication Rate (%)mentioning

confidence: 99%

Section: Pulmonary Complication Rate (%)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Transhiatal versus transthoracic surgical approach for Siewert type Ⅱ adenocarcinoma of the esophagogastric junction: a meta-analysis

Shang

et al. 2020

Expert Review of Gastroenterology & Hepatology

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Tandem mass tagging combined with liquid chromatography–tandem mass spectrometry technique to detect protein markers in gastroesophageal junction adenocarcinoma

Zheng

Yang

et al. 2022

Rapid Comm Mass Spectrometry

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Background Gastroesophageal junction adenocarcinoma (GEJA) is a malignant tumor located at the junction of the esophagus and stomach, the incidence of which is increasing year by year, while screening for early biomarkers is limited. Tandem mass tagging (TMT) coupled with liquid chromatography–tandem mass spectrometry (LC/MS/MS) has been used to screen for differential proteins in various cancers. Methods Differential proteins in GEJA and precancerous lesions were screened using TMT–LC/MS/MS, and then proteins that met expectations were selected for trend clustering analysis, combined with GO and KEGG analysis for functional annotation of differential proteins in GEJA. Then, parallel reaction monitoring and immunohistochemistry techniques were used to validate the accuracy of the proteomics data. Results Our group screened the differential proteins during GEJA progression using proteomics technology, analyzed the expression trends and functional regions involved in the differential proteins during carcinogenesis, and validated the accuracy of the experimental results. Conclusions The screening of differential proteins in GEJA carcinogenesis based on TMT–LC/MS/MS technology provides detailed information for the elucidation of GEJA progression process, pathogenesis, early screening and screening of candidate markers.

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Oesophagectomy or Total Gastrectomy for the Management of Siewert II Gastroesophageal Junction Cancer: a Systematic Review and Meta-analysis

Walmsley

Berrisford

Humphreys

et al. 2023

Journal of Gastrointestinal Surgery

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Transhiatal distal esophagectomy for Siewert type II cardia cancer can be a treatment option in selected patients

Cited by 12 publications

References 24 publications

Transhiatal versus transthoracic surgical approach for Siewert type Ⅱ adenocarcinoma of the esophagogastric junction: a meta-analysis

Transhiatal versus transthoracic surgical approach for Siewert type Ⅱ adenocarcinoma of the esophagogastric junction: a meta-analysis

Tandem mass tagging combined with liquid chromatography–tandem mass spectrometry technique to detect protein markers in gastroesophageal junction adenocarcinoma

Oesophagectomy or Total Gastrectomy for the Management of Siewert II Gastroesophageal Junction Cancer: a Systematic Review and Meta-analysis

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