Transient Acquired Blood Group B Antigen Associated with Diverticular Bowel Disease

Abstract

Transient acquired B red cell antigen was found in a patient with inflammatory bowel disease. Removal of the affected portion of the bowel was associated with disappearance of the B antigen. This phenomenon has usually been recorded in association with neoplasms of the bowel, but appears to be a marker for the release of bacterial enzymes into the systemic circulation associated with breakdown of the normal bowel barrier to such materials.

Identification of 5 novel feline erythrocyte antigens based on the presence of naturally occurring alloantibodies

“…In addition, autocontrols were systematically performed, and RBC washed 3 times, making unlikely an impact of autoagglutination on our results. Although rarely described in human medicine, we cannot rule out the presence of acquired antigen or altered antigen expression on RBC surface in unhealthy cats 39‐43 . Furthermore, while statistical association was not found between the presence of NOAb and health status in our study, the effect of some diseases on NOAb (titer, specificity, etc) is unknown.…”

“…Although rarely described in human medicine, we cannot rule out the presence of acquired antigen or altered antigen expression on RBC surface in unhealthy cats. [39][40][41][42][43] Furthermore, while statistical association was not found between the presence of NOAb and health status in our study, the effect of some diseases on NOAb (titer, specificity, etc) is unknown. That said, even if health status had an influence on FEA and NOAb expression, which remains to be investigated, our main conclusion would remain unchanged (ie, 5 presumably distinct novel antigens were identified).…”