Transient elastography: a valid alternative to biopsy in patients with chronic liver disease

Gómez-Domínguez, Elena; Mendoza, Jorge; Rubio, Saioa; Moreno-Monteagudo, J.A.; Garcı́a-Buey, Luisa; Moreno–Otero, Ricardo

doi:10.1111/j.1365-2036.2006.02999.x

Cited by 103 publications

(52 citation statements)

References 23 publications

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“…Optimal cut-off values for significant fibrosis in patients with CHC (stage of fibrosis ≥ 2) have been reported to range from 7.1 to 8.7 KPa (4-7). This range is consistent with our data (37).…”

Section: Strategies and Evidencesupporting

confidence: 83%

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Hepatic fibrosis in patients with chronic hepatitis C assessed by transient elastography: implications for determining the efficacy of antiviral therapy

Mendoza

Trapero-Marugán

González-Moreno

et al. 2010

Rev. esp. enferm. dig.

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Section: Strategies and Evidencesupporting

confidence: 83%

“…Currently, there are insufficient data to enable the reliability of assessments of mild hepatic fibrosis in HCV-infected patients using TE to be determined accurately (4)(5)(6)(7)19,37).…”

Section: Areas Of Uncertaintymentioning

confidence: 99%

Hepatic fibrosis in patients with chronic hepatitis C assessed by transient elastography: implications for determining the efficacy of antiviral therapy

Mendoza

Trapero-Marugán

González-Moreno

et al. 2010

Rev. esp. enferm. dig.

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“…Knowing that malignant tissues are generally harder than normal surrounding tissue, elastography might provide interesting clinical information to help distinguish benign from malignant tissue based on their specific tissue consistency. Clinical research has shown promising results in differentiating between benign and malignant tissue in the thyroid gland [5] , breast [6][7][8] , prostate [9,10] and to assess liver fibrosis [11][12][13][14] . Recently, elastography has also been introduced during EUS examination [15][16][17][18][19] .…”

Section: Introductionmentioning

confidence: 99%

Endoscopic ultrasound elastography for evaluation of lymph nodes and pancreatic masses: A multicenter study

Giovannini¹,

Botelberge²,

Bories³

et al. 2009

WJG

252

183

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AIM:To evaluate the ability of endoscopic ultrasound (EUS) elastography to distinguish benign from malignant pancreatic masses and lymph nodes. METHODS:A multicenter study was conducted and included 222 patients who underwent EUS examination with assessment of a pancreatic mass (n = 121) or lymph node (n = 101). The classification as benign or malignant, based on the real time elastography pattern, was compared with the classification based on the B-mode EUS images and with the final diagnosis obtained by EUS-guided fine needle aspiration (EUS-FNA) and/or by surgical pathology. An interobserver study was performed. RESULTS:The sensitivity and specificity of EUS elastography to differentiate benign from malignant pancreatic lesions are 92.3% and 80.0%, respectively, compared to 92.3% and 68.9%, respectively, for the conventional B-mode images. The sensitivity and specificity of EUS elastography to differentiate benign from malignant lymph nodes was 91.8% and 82.5%, respectively, compared to 78.6% and 50.0%, respectively, for the B-mode images. The kappa coefficient was 0.785 for the pancreatic masses and 0.657 for the lymph nodes.CONCLUSION: EUS elastography is superior compared to conventional B-mode imaging and appears to be able to distinguish benign from malignant pancreatic masses and lymph nodes with a high sensitivity, specificity and accuracy. It might be reserved as a second line examination to help characterise pancreatic masses after negative EUS-FNA and might increase the yield of EUS-FNA for lymph nodes.

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“…Therefore, there is an increasing need for alternative noninvasive methods to estimate the stage of liver fibrosis [12][13][14][15][16][17][18][19][20][21] . Transient elastography and real-time tissue elastography are recently developed technologies, which are safe and noninvasive techniques to evaluate fibrosis in chronic liver disease.…”

mentioning

confidence: 99%

Noninvasive Evaluation of Hepatic Fibrosis Using Serum Fibrotic Markers, Transient Elastography (FibroScan) and Real-Time Tissue Elastography

Kudo¹,

Ueshima²,

Kitai³

et al. 2008

Intervirology

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Objective: The aim of this study was to investigate the accuracy of noninvasive tests, e.g. serum fibrotic markers, transient elastography and real-time tissue elastography, in the diagnosis of hepatic fibrosis, and to determine whether they can replace liver biopsy. Methods: 119 patients with chronic liver disease were included in this study. Serum fibrotic markers including hyaluronic acid, type IV collagen, type IV collagen 7S domain and type III procollagen-N-peptide were measured. Aspartate aminotransferase (AST) and platelet counts were also measured to calculate the AST to platelet ratio index (APRI). Liver stiffness was measured using FibroScan and real-time tissue elastography. Results: The fibrotic stage, determined by histopathological diagnosis of a liver biopsy sample, did not correlate as well with serum fibrotic markers although it was useful to diagnose liver cirrhosis. However, the stage of hepatic fibrosis correlated well with liver stiffness measured by FibroScan. FibroScan was also a much better predictor of liver cirrhosis than APRI. Furthermore, the levels of liver strain measured by real-time tissue elastography correlated well with liver stiffness (p < 0.05). Conclusion: Serum fibrotic markers and FibroScan are useful for distinguishing liver cirrhosis (F₄) from chronic hepatitis (F₁–F₃). In addition, real-time tissue elastography is a novel and promising method to determine the stage of hepatic fibrosis.

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Transient elastography: a valid alternative to biopsy in patients with chronic liver disease

Abstract: SUMMARY BackgroundTransient elastography is a novel and non-invasive technique for the evaluation of fibrosis in chronic liver disease. Few studies that exist value the efficacy of transient elastography, mainly in hepatitis C virusinfected patients.

Cited by 103 publications

References 23 publications

Hepatic fibrosis in patients with chronic hepatitis C assessed by transient elastography: implications for determining the efficacy of antiviral therapy

Hepatic fibrosis in patients with chronic hepatitis C assessed by transient elastography: implications for determining the efficacy of antiviral therapy

Endoscopic ultrasound elastography for evaluation of lymph nodes and pancreatic masses: A multicenter study

Noninvasive Evaluation of Hepatic Fibrosis Using Serum Fibrotic Markers, Transient Elastography (FibroScan) and Real-Time Tissue Elastography

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