Transient hyperphosphatasaemia of infancy following rotavirus infection

Holt, P.A.; Steel, A. E.; Armstrong, Andrea

doi:10.1016/s0163-4453(84)90640-6

Cited by 16 publications

(7 citation statements)

References 6 publications

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“…A review of the literature reveals that THP was found mostly in cases with unspecified upper [4,13] airway infections or mild gastrointestinal disease. Holt et al [6], reported a case of THP following rotavirus infection. THP is found up to 4.5 years of age, but Rosatki et al [13] reported a 21-year-old man with THP who subsequently developed Crohn disease.…”

Section: Discussionmentioning

confidence: 99%

Transient hyperphosphatasaemia of infancy

1988

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In five patients with benign transient hyperphosphatasaemia (THP), high activities of so-called "atypical" alkaline phosphatase or fragment isoenzymes were detected. One case occurred after rotavirus infection. Incubation with neuraminidase suggested that "atypical" alkaline phosphatase originated from highly glycosylated bone and liver isoenzymes. This may have been due to virus-induced low isoenzyme clearance from serum. The course of isoenzyme activities in THP following rotavirus infection was followed. Determination of atypical alkaline phosphatase may be useful in the diagnosis of THP.

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Section: Discussionmentioning

confidence: 99%

Transient hyperphosphatasaemia of infancy

1988

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“…The benign elevation of AP is referred to as transient hyperphosphatasemia (THP), a condition most commonly observed in infants and children younger than 5 years of age without evidence of bone, gastrointestinal or liver disease on history, physical examination or laboratory investigations. Furthermore, this condition has no long-term adverse consequences 1,2. Because the epidemiology of THP is not well understood and clear guidelines for evaluating this problem are lacking, THP is usually diagnosed by excluding other diseases, which, may require extensive biochemical and radiographic studies, all adding significant costs for the health care system.…”

Section: Introductionmentioning

confidence: 99%

“…Furthermore, this condition has no long-term adverse consequences. 1,2 Because the epidemiology of THP is not well understood and clear guidelines for evaluating this problem are lacking, THP is usually diagnosed by excluding other diseases, which, may require extensive biochemical and radiographic studies, all adding significant costs for the health care system. Herein, with the help of an illustrative example, we suggest a clinical algorithm outlining minimum tests for the diagnosis and management of a patient with THP avoiding unnecessary investigations and referral to a specialist.…”

Section: Introductionmentioning

confidence: 99%

Elevated Alkaline Phosphatase in Children: An Algorithm to Determine When a “Wait and See” Approach is Optimal

Otero

González‐Peralta

Andres

et al. 2011

Clin Med Insights Pediatr

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Due to the possibility of underlying hepatobiliaryor bone diseases, the diagnostic work up of a child with elevated alkaline phosphatase (AP) levels can be quite costly. In a significant proportion of these patients, elevated AP is benign, requiring no intervention: hence, known as transient hyperphosphatasemia (THP) of infants and children. A 27-month old previously healthy Caucasian female was found to have isolated elevation of AP four weeks after the initial symptoms of acute gastroenteritis. One month later, when seen in hepatobiliary clinic, signs and symptoms of gastrointestinal, hepatobiliary, or bone disease were absent and physical examination was normal. The diagnosis of THP was made, and, as anticipated, AP levels normalized after four months. Using this case as an example, we suggest an algorithm that can be utilized as a guide in a primary care setting to arrive at the diagnosis of THP and avoid further tests or referrals.

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“…The full duration of the rise of ALP activity in BTH has only been documented in a few patients and it has been found that ALP peaks at about 6 weeks and normalises at about 12 weeks 5 , 12. In our first case, we coincidentally made the second ALP measurement near to the probable peak time; ALP was almost normal at 5–6 weeks (365 IU/litre) and was completely normal at 11 weeks (230 IU/litre).…”

Section: Discussionmentioning

confidence: 63%

Transient rise in alkaline phosphatase activity in adults

et al. 2009

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Benign transient hyperphosphatasia (BTH) is a condition that occurs mainly in infants and children and is characterised by a transient increase of serum alkaline phosphatase (ALP) activity up to several fold the adult upper reference limit (URL). The present report concerns BTH in 2 patients, aged 59 and 52 years old, who showed no evidence of bone or liver disease but had an increase in ALP activity up to 20-fold and 13-fold the adult URL, respectively. The diagnosis of BTH in the first case was made retrospectively, and after excluding liver and bone disease. However, in the second case the diagnosis was made early in the course of the disease, by performing an ALP isoenzyme electrophoresis test. Lengthy and extensive investigations were avoided in the second case. These cases highlight the occurrence of this condition in adulthood as well as in infancy and childhood.

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Transient hyperphosphatasaemia of infancy following rotavirus infection

Cited by 16 publications

References 6 publications

Transient hyperphosphatasaemia of infancy

Transient hyperphosphatasaemia of infancy

Elevated Alkaline Phosphatase in Children: An Algorithm to Determine When a “Wait and See” Approach is Optimal

Transient rise in alkaline phosphatase activity in adults

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