Transient prenatal Vitamin D deficiency is associated with hyperlocomotion in adult rats

Burne, Thomas H. J.; Becker, Axel; Brown, Jillanne; Eyles, Darryl W.; Mackay‐Sim, Alan; McGrath, John J.

doi:10.1016/j.bbr.2004.03.023

Cited by 132 publications

(118 citation statements)

References 27 publications

Supporting

Mentioning

108

Contrasting

Unclassified

Order By: Relevance

“…were hyper-explorative on the hole-board test [40]. Adult DVD deficient rats are more active than controls in novel environments [47,48], show an increased psychomimetic-induced hyperlocomotion and an enhanced startle response after MK-801 injection [49,50]. This suggests that the absence of vitamin D may lead to alterations in similar neural circuits in both the developing and adult brain.…”

Section: Hot Plate Testmentioning

confidence: 99%

Adult vitamin D deficiency leads to behavioural and brain neurochemical alterations in C57BL/6J and BALB/c mice

Groves

Kesby

Eyles

et al. 2013

Behavioural Brain Research

Self Cite

126

111

View full text Add to dashboard Cite

Epidemiological evidence suggests that low levels of vitamin D may predispose people to develop depression and cognitive impairment. While rodent studies have demonstrated that prenatal vitamin D deficiency is associated with altered brain development, there is a lack of research examining adult vitamin D (AVD) deficiency.The aim of this study was to examine the impact of AVD deficiency on behaviour and brain function in the mouse. Ten-week old male C57BL/6J and BALB/c mice were fed a control or vitamin D deficient diet for 10 weeks prior to, and during behavioural testing. We assessed a broad range of behavioural domains, excitatory and inhibitory neurotransmission in brain tissue, and, in separate groups of mice, locomotor response to D-amphetamine and MK-801. Overall, AVD deficiency resulted in hyperlocomotion in a novel open field and reduced GAD65/67 levels in brain tissue. AVD-deficient BALB/c mice had altered behaviour on the elevated plus maze, altered responses to heat, sound and shock, and decreased levels of glutamate and glutamine, and increased levels of GABA and glycine. By contrast C57BL/6 mice had a more subtle phenotype with no further behavioural changes but significant elevations in serine, homovanillic acid and 5-hydroxyindoleacetic acid.Although the behavioural phenotype of AVD did not seem to model a specific disorder, the overall reduction in GAD65/67 levels associated with AVD deficiency may be relevant to a number of neuropsychiatric conditions. This is the first study to show an association between AVD deficiency and prominent changes in behaviour and brain neurochemistry in the mouse.3

show abstract

Section: Hot Plate Testmentioning

confidence: 99%

Adult vitamin D deficiency leads to behavioural and brain neurochemical alterations in C57BL/6J and BALB/c mice

Groves

Kesby

Eyles

et al. 2013

Behavioural Brain Research

Self Cite

126

111

View full text Add to dashboard Cite

show abstract

“…While some studies reported no observed impairments in working memory or anxiety in the VDR-KO model (Burne, JJ et al 2005), others showed anxiety-like behavior and behavioral impairment (Kalueff, Lou et al 2004;Kalueff, Keisala et al 2006). In embryonic animal models, vitamin D deficiency during fetal development resulted in morphological brain changes (Eyles, Brown et al 2003), motor impairments (Burne, Becker et al 2004) and memory and learning impairments (McGrath, Eyles et al 2003;Becker, Eyles et al 2005).…”

Section: Vitamin D and Neurocognitive Function: Deciphering The Evidencementioning

confidence: 99%

Vitamin D and neurocognitive dysfunction: Preventing “D”ecline?

Buell

Dawson‐Hughes

2008

Molecular Aspects of Medicine

310

222

View full text Add to dashboard Cite

show abstract

“…One of the most replicated adult behavioural changes following DVD-deficiency in the Sprague Dawley rat is hyperlocomotion in a novel arena, which has been observed across a range of tests including the hole-board, elevated plus maze, and the open field [12,13]. Brief restraint stress prior to testing also abolishes this affect.…”

Section: Hyperlocomotionmentioning

confidence: 99%

The impact of vitamin D deficiency on behaviour and brain function in rodents

Overeem

Eyles

McGrath

2016

Current Opinion in Behavioral Sciences

View full text Add to dashboard Cite

Vitamin D deficiency has been proposed as an environmental risk factor for several neurological disorders. To investigate the biological plausibility of this risk factor, vitamin D (DVD) deficiency rodent models have been used to examine the impact of DVD deficiency on neurobiology and behaviour. The majority of these studies have taken a developmental stance and examined the impact of vitamin D deficiency during gestation on the adult behaviour of the offspring. In the rat, the most constant behavioural phenotypes include hyperlocomotion in response to novelty, psychostimulant sensitively, impulsivity, and augmented motivation. However, in the mouse increased exploratory behaviour and

show abstract

Transient prenatal Vitamin D deficiency is associated with hyperlocomotion in adult rats

Cited by 132 publications

References 27 publications

Adult vitamin D deficiency leads to behavioural and brain neurochemical alterations in C57BL/6J and BALB/c mice

Adult vitamin D deficiency leads to behavioural and brain neurochemical alterations in C57BL/6J and BALB/c mice

Vitamin D and neurocognitive dysfunction: Preventing “D”ecline?

The impact of vitamin D deficiency on behaviour and brain function in rodents

Contact Info

Product

Resources

About